Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract
| Main Authors: | Warsinah, Warsinah, Sismindari, Sismindari, Susidarti, Ratna Asmah |
|---|---|
| Format: | Article info application/pdf Document |
| Bahasa: | eng |
| Terbitan: |
Indonesian Society for Cancer Chemoprevention
, 2011
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| Online Access: |
https://ijcc.chemoprev.org/index.php/ijcc/article/view/47 https://ijcc.chemoprev.org/index.php/ijcc/article/view/47/48 |
| ctrlnum |
article-47 |
|---|---|
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract</title><creator>Warsinah, Warsinah</creator><creator>Sismindari, Sismindari</creator><creator>Susidarti, Ratna Asmah</creator><description lang="en-US">The Antiproliferative effects of methanol extract from Bruguiera gymnorhiza (B. gymnorhiza) barks were tested in vitro against three human cell lines: Hela, Raji and Myeloma cells. The extract was found to have antiproliferative effects against Hela, Raji and Myeloma cells with an IC50 value of 133, 504 and 384 µg/mL, respectively. The antiproliferative test was then performed on Hela, Raji, and Myeloma cells. Cytotoxicity assay of the extract was then determined using MTT method. There were some indications of apoptosis, such DNA fragmentation, as assessed by acrydine orange- ethidium bromide staining. These results indicate that extract from B. gymnorhiza barks can induce apoptosis in human cell lines.Keywords: Antiproliferative, Apoptosis, B. gymnorhiza</description><publisher lang="en-US">Indonesian Society for Cancer Chemoprevention</publisher><contributor lang="en-US"/><date>2011-10-31</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/47</identifier><identifier>10.14499/indonesianjcanchemoprev2iss3pp299-303</identifier><source lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 2, No 3 (2011); 299-303</source><source>2355-8989</source><source>2088-0197</source><language>eng</language><relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/47/48</relation><rights lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</rights><recordID>article-47</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Document:Document Document |
| author |
Warsinah, Warsinah Sismindari, Sismindari Susidarti, Ratna Asmah |
| title |
Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract |
| publisher |
Indonesian Society for Cancer Chemoprevention |
| publishDate |
2011 |
| url |
https://ijcc.chemoprev.org/index.php/ijcc/article/view/47 https://ijcc.chemoprev.org/index.php/ijcc/article/view/47/48 |
| contents |
The Antiproliferative effects of methanol extract from Bruguiera gymnorhiza (B. gymnorhiza) barks were tested in vitro against three human cell lines: Hela, Raji and Myeloma cells. The extract was found to have antiproliferative effects against Hela, Raji and Myeloma cells with an IC50 value of 133, 504 and 384 μg/mL, respectively. The antiproliferative test was then performed on Hela, Raji, and Myeloma cells. Cytotoxicity assay of the extract was then determined using MTT method. There were some indications of apoptosis, such DNA fragmentation, as assessed by acrydine orange- ethidium bromide staining. These results indicate that extract from B. gymnorhiza barks can induce apoptosis in human cell lines.Keywords: Antiproliferative, Apoptosis, B. gymnorhiza |
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