Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione
| Main Authors: | Pantelić Nebojša, Zmejkovski Bojana B, Žižak Željko, Banjac Nabojša B, Božić Bojan Đ, Stanojković Tatjana P, Kaluđerovoć Goran N |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4441220 |
| ctrlnum |
4441220 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Pantelić Nebojša</creator><creator>Zmejkovski Bojana B</creator><creator>Žižak Željko</creator><creator>Banjac Nabojša B</creator><creator>Božić Bojan Đ</creator><creator>Stanojković Tatjana P</creator><creator>Kaluđerovoć Goran N</creator><date>2019-01-17</date><description>A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC50 values in the range of 0.22 to 0.53 µM. The highest activity organotin(IV) compound expressed against the HeLa cells (IC50 =&thinsp;0.22 ± 0.04 µM). The ligand precursor did not show anticancer activity (IC50 > 200 µM). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.</description><description>Supplementary material:
https://www.hindawi.com/journals/jchem/2019/2905840/#supplementary-materials</description><identifier>https://zenodo.org/record/4441220</identifier><identifier>10.1155/2019/2905840</identifier><identifier>oai:zenodo.org:4441220</identifier><language>eng</language><relation>info:eu-repo/grantAgreement/MESTD/Basic+Research+%28BR+or+ON%29/172035/</relation><relation>info:eu-repo/grantAgreement/MESTD/Basic+Research+%28BR+or+ON%29/175011/</relation><relation>url:https://www.hindawi.com/journals/jchem/2019/2905840</relation><relation>url:https://zenodo.org/communities/iors</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/licenses/by/4.0/legalcode</rights><source>Journal Chemistry 2019(Article ID 2905840) 8 pages.</source><subject>anticancer activity</subject><subject>biological evaluation</subject><subject>in vitro</subject><subject>tumor cell lines</subject><title>Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione</title><type>Journal:Article</type><type>Journal:Article</type><recordID>4441220</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Journal:Journal |
| author |
Pantelić Nebojša Zmejkovski Bojana B Žižak Željko Banjac Nabojša B Božić Bojan Đ Stanojković Tatjana P Kaluđerovoć Goran N |
| title |
Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione |
| publishDate |
2019 |
| topic |
anticancer activity biological evaluation in vitro tumor cell lines |
| url |
https://zenodo.org/record/4441220 |
| contents |
A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC50 values in the range of 0.22 to 0.53 μM. The highest activity organotin(IV) compound expressed against the HeLa cells (IC50 = 0.22 ± 0.04 μM). The ligand precursor did not show anticancer activity (IC50 > 200 μM). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase. Supplementary material: https://www.hindawi.com/journals/jchem/2019/2905840/#supplementary-materials |
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IOS16997.4441220 |
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ZAIN Publications |
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7213 |
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library:special library |
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Cognizance Journal of Multidisciplinary Studies |
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5267 |
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Cognizance Journal of Multidisciplinary Studies |
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Multidisciplinary |
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Stockholm |
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INTERNASIONAL |
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1 |
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2022-06-06T04:51:40Z |
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2022-06-06T04:51:40Z |
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