Batasan Prostate Specific Antigen (PSA) Pada Pasien Kanker Prostat Untuk Memprediksi Metastasis ke Tulang di Rumah Sakit Sardjito, Yogyakarta = Predicting Bone Metastasis in Prostate Cancer Patients: Value of Prostate Specific Antigen at Sardjito Hospital,Yogyakarta
| Main Authors: | Ahmad Sulaiman Lubis, HR. Danarto |
|---|---|
| Format: | Masters x, 15 hlm, 21 x 29 cm |
| Bahasa: | ind |
| Terbitan: |
Program Pendidikan Dokter Spesialis Urologi
, 2014
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| Subjects: | |
| Online Access: |
http://library.fk.ui.ac.id//index.php?p=show_detail&id=19128 http://library.fk.ui.ac.id//lib/minigalnano/createthumb.php?filename=images/docs/cover_batasan-prostate-specific-antigen-psa-pada-pasien-kanker-prostat-unt-20231013133125.jpg&width=200 http://library.fk.ui.ac.id//index.php?p=show_detail&id=19245 |
| ctrlnum |
slims-19128 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>Batasan Prostate Specific Antigen (PSA) Pada Pasien Kanker Prostat Untuk Memprediksi Metastasis ke Tulang di Rumah Sakit Sardjito, Yogyakarta = Predicting Bone Metastasis in Prostate Cancer Patients: Value of Prostate Specific Antigen at Sardjito Hospital,Yogyakarta</title><creator>Ahmad Sulaiman Lubis</creator><creator>HR. Danarto</creator><subject>Metastasis tulang</subject><subject>Porstate Spesific Antigen</subject><subject>Specific antigen</subject><subject>Pasien kanker prostat</subject><subject>Bone scintigraphy</subject><subject>Prostate Cancer</subject><relation>http://library.fk.ui.ac.id//index.php?p=show_detail&id=19245</relation><publisher>Program Pendidikan Dokter Spesialis Urologi</publisher><date>2014</date><language>ind</language><type>Thesis:Masters</type><identifier>http://library.fk.ui.ac.id//index.php?p=show_detail&id=19128</identifier><identifier>T14430fk</identifier><description>Tujuan: Mengetahui batasan nilai PSA untuk memprediksi adanya metastasistulang pada pasien kanker prostat di RS Sardjito.Metode: Penelitian retrospektif, dengan mengumpulkan rekam medis pasienkanker prostat telah dilakukan bone scintigraphy di RS Sardjito tahun 2006 -2011.Hasil: Dari 83 pasien kanker prostat yang telah dilakukan bone scintigraphy,terdapat 55 pasien (66%) mengalami metastasis tulang dan terdapat 28 pasien (34 %) yang tidak mengalami metastasis tulang. Dari 55 pasien yang mengalami metastasis tulang, terdapat 11 pasien (20 %) dengan PSA kurang dari 20 ng/mldan terdapat 44 pasien (80 %) yang memiliki PSA lebih dari 20 ng/ml. Cut-offpoint PSA 17.65 ng/ml memiliki sensitivitas terbesar yaitu 85.5% dan spesifisitas53.6%.Kesimpulan: Pemeriksaan bone scintigraphy dianjurkan pada pasien dengan PSA> 17.65 ng/ml, sedangkan pada pasien dengan PSA < 17.65 dianjurkan padapasien dengan gejala klinis nyeri tulang.Objective: Prostate cancer shows a strong predilection to spread to the bones,with bone metastases identified at autopsy in up to 90 % of patients dying fromprostate cancer. Serum prostate specific antigen (PSA) concentration has beenwidely applied as a biomarker to diagnose and monitor prostate cancer.Technetium-99m methylene diphosphate (Tc—99m MDP) whole body bonescintigraphy is currently a well-accepted diagnostic procedure for bone metastasisin malignancy. The aim of this study was to establish a useful serum PSA cut-offvalue to predict the presence of bone metastasis in men with prostate cancer. Material and Methods: Consecutive male patients diagnosed with prostate cancer were retrospectively analyzed. All of the subjects had received Tc-99mMDP whole body bone scintigraphy and had their serum PSA concentrationmeasured at Sardjito Hospital, Yogyakarta. The proper cut-off value wasestablished based on statistical analysis in order to predict the possibility of bonemetastasis among prostate cancer patients.Results: In total, 83 consecutive male patients with prostate cancer were enrolled,and 55 patients (66 %) were confirmed by scintigraphic findings to have bonemetastases. A serum PSA concentration of 17,65 ng/ml gave the best sensitivity(78,33 %) and specificity (65,21 %). The positive predictive value, negativepredictive value were 85,45 % and 53,57 %, respectively (p</description><coverage>Jakarta</coverage><identifier>http://library.fk.ui.ac.id//lib/minigalnano/createthumb.php?filename=images/docs/cover_batasan-prostate-specific-antigen-psa-pada-pasien-kanker-prostat-unt-20231013133125.jpg&width=200</identifier><type>Other:x, 15 hlm, 21 x 29 cm</type><subject>NONE</subject><image>http://library.fk.ui.ac.id//lib/minigalnano/createthumb.php?filename=images/docs/cover_batasan-prostate-specific-antigen-psa-pada-pasien-kanker-prostat-unt-20231013133125.jpg&width=200</image><recordID>slims-19128</recordID></dc>
|
| language |
ind |
| format |
Thesis:Masters Thesis Other:x, 15 hlm, 21 x 29 cm Other |
| author |
Ahmad Sulaiman Lubis HR. Danarto |
| title |
Batasan Prostate Specific Antigen (PSA) Pada Pasien Kanker Prostat Untuk Memprediksi Metastasis ke Tulang di Rumah Sakit Sardjito, Yogyakarta = Predicting Bone Metastasis in Prostate Cancer Patients: Value of Prostate Specific Antigen at Sardjito Hospital,Yogyakarta |
| publisher |
Program Pendidikan Dokter Spesialis Urologi |
| publishDate |
2014 |
| isbn |
2023101313312 |
| topic |
Metastasis tulang Porstate Spesific Antigen Specific antigen Pasien kanker prostat Bone scintigraphy Prostate Cancer NONE |
| url |
http://library.fk.ui.ac.id//index.php?p=show_detail&id=19128 http://library.fk.ui.ac.id//lib/minigalnano/createthumb.php?filename=images/docs/cover_batasan-prostate-specific-antigen-psa-pada-pasien-kanker-prostat-unt-20231013133125.jpg&width=200 http://library.fk.ui.ac.id//index.php?p=show_detail&id=19245 |
| contents |
Tujuan: Mengetahui batasan nilai PSA untuk memprediksi adanya metastasistulang pada pasien kanker prostat di RS Sardjito.Metode: Penelitian retrospektif, dengan mengumpulkan rekam medis pasienkanker prostat telah dilakukan bone scintigraphy di RS Sardjito tahun 2006 -2011.Hasil: Dari 83 pasien kanker prostat yang telah dilakukan bone scintigraphy,terdapat 55 pasien (66%) mengalami metastasis tulang dan terdapat 28 pasien (34 %) yang tidak mengalami metastasis tulang. Dari 55 pasien yang mengalami metastasis tulang, terdapat 11 pasien (20 %) dengan PSA kurang dari 20 ng/mldan terdapat 44 pasien (80 %) yang memiliki PSA lebih dari 20 ng/ml. Cut-offpoint PSA 17.65 ng/ml memiliki sensitivitas terbesar yaitu 85.5% dan spesifisitas53.6%.Kesimpulan: Pemeriksaan bone scintigraphy dianjurkan pada pasien dengan PSA> 17.65 ng/ml, sedangkan pada pasien dengan PSA < 17.65 dianjurkan padapasien dengan gejala klinis nyeri tulang.Objective: Prostate cancer shows a strong predilection to spread to the bones,with bone metastases identified at autopsy in up to 90 % of patients dying fromprostate cancer. Serum prostate specific antigen (PSA) concentration has beenwidely applied as a biomarker to diagnose and monitor prostate cancer.Technetium-99m methylene diphosphate (Tc—99m MDP) whole body bonescintigraphy is currently a well-accepted diagnostic procedure for bone metastasisin malignancy. The aim of this study was to establish a useful serum PSA cut-offvalue to predict the presence of bone metastasis in men with prostate cancer. Material and Methods: Consecutive male patients diagnosed with prostate cancer were retrospectively analyzed. All of the subjects had received Tc-99mMDP whole body bone scintigraphy and had their serum PSA concentrationmeasured at Sardjito Hospital, Yogyakarta. The proper cut-off value wasestablished based on statistical analysis in order to predict the possibility of bonemetastasis among prostate cancer patients.Results: In total, 83 consecutive male patients with prostate cancer were enrolled,and 55 patients (66 %) were confirmed by scintigraphic findings to have bonemetastases. A serum PSA concentration of 17,65 ng/ml gave the best sensitivity(78,33 %) and specificity (65,21 %). The positive predictive value, negativepredictive value were 85,45 % and 53,57 %, respectively (p |
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Universitas Indonesia |
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e-Library FKUI |
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JAKARTA PUSAT |
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DKI JAKARTA |
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2023-11-06T08:03:34Z |
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