Neurodevelopmental disorder risk in babies with history of hyperbilirubinemia
| Main Authors: | Hutahaean, Baginda , Putranti, Alifiani Hikmah, Rahardjani, Kamilah Budhi |
|---|---|
| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Ikatan Dokter Anak Indonesia
, 2008
|
| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/676/1/baginda48-2-7.pdf http://www.idai.or.id/pi/default.asp http://eprints.undip.ac.id/676/ |
| ctrlnum |
676 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>Neurodevelopmental disorder risk in babies with
history of hyperbilirubinemia</title><creator>Hutahaean, Baginda </creator><creator>Putranti, Alifiani Hikmah</creator><creator>Rahardjani, Kamilah Budhi </creator><subject>RJ101 Child Health. Child health services</subject><description>Background Neurodevelopmental disorder (ND) is defined as
failure to attain normal neurological function. Indirect bilirubin
has essential role because its neurotoxic properties. Neonates with
hyperbilirubinemia carry the risk to develop ND.
Objective To determine the association between neonatal indirect
hyperbilirubinemia and the risk of ND.
Methods Neonates with indirect serum bilirubin (SIB) level >10
mg/dL, admitted in the period of October 2004-August 2005, were
included in this study. They were followed-up and screened using
Bayley Infant Neurodevelopmental Screener (BINS) at three, six
and nine months. Mann-Whitney test was used to test the
hypothesis.
Results Forty-eight neonates were included in the study. Mean
SIB level of subjects with ND risk was 20.5 mg/dL (SD=6.06;
p<0.001). Mean SIB level of subjects who developed ND at three,
six and nine months was 31.6 mg/dL (SD=4.02), 18.4 mg/dL
(SD=2.92) and 18.4 mg/dL (SD=5.41), respectively. There was
statistically significant correlation between SIB level and ND
risk (R=+0.64; P<0.001). There was also statistically significant
correlation between SIB level and the onset of ND (R=-0.63;
P< 0.001).
Conclusion There is a correlation between neonatal SIB level
and the risk of ND in babies. [Paediatr Indones 2008;48:93-
98].</description><publisher>Ikatan Dokter Anak Indonesia</publisher><date>2008</date><type>Journal:Article</type><type>PeerReview:PeerReviewed</type><type>File:application/pdf</type><identifier>http://eprints.undip.ac.id/676/1/baginda48-2-7.pdf</identifier><relation>http://www.idai.or.id/pi/default.asp</relation><identifier>Hutahaean, Baginda and Putranti, Alifiani Hikmah and Rahardjani, Kamilah Budhi (2008) Neurodevelopmental disorder risk in babies with history of hyperbilirubinemia. Paediatrica Indonesiana, 48 (1). pp. 93-97. ISSN 0030-9311</identifier><relation>http://eprints.undip.ac.id/676/</relation><recordID>676</recordID></dc>
|
| format |
Journal:Article Journal PeerReview:PeerReviewed PeerReview File:application/pdf File |
| author |
Hutahaean, Baginda Putranti, Alifiani Hikmah Rahardjani, Kamilah Budhi |
| title |
Neurodevelopmental disorder risk in babies with
history of hyperbilirubinemia |
| publisher |
Ikatan Dokter Anak Indonesia |
| publishDate |
2008 |
| topic |
RJ101 Child Health. Child health services |
| url |
http://eprints.undip.ac.id/676/1/baginda48-2-7.pdf http://www.idai.or.id/pi/default.asp http://eprints.undip.ac.id/676/ |
| contents |
Background Neurodevelopmental disorder (ND) is defined as
failure to attain normal neurological function. Indirect bilirubin
has essential role because its neurotoxic properties. Neonates with
hyperbilirubinemia carry the risk to develop ND.
Objective To determine the association between neonatal indirect
hyperbilirubinemia and the risk of ND.
Methods Neonates with indirect serum bilirubin (SIB) level >10
mg/dL, admitted in the period of October 2004-August 2005, were
included in this study. They were followed-up and screened using
Bayley Infant Neurodevelopmental Screener (BINS) at three, six
and nine months. Mann-Whitney test was used to test the
hypothesis.
Results Forty-eight neonates were included in the study. Mean
SIB level of subjects with ND risk was 20.5 mg/dL (SD=6.06;
p<0.001). Mean SIB level of subjects who developed ND at three,
six and nine months was 31.6 mg/dL (SD=4.02), 18.4 mg/dL
(SD=2.92) and 18.4 mg/dL (SD=5.41), respectively. There was
statistically significant correlation between SIB level and ND
risk (R=+0.64; P<0.001). There was also statistically significant
correlation between SIB level and the onset of ND (R=-0.63;
P< 0.001).
Conclusion There is a correlation between neonatal SIB level
and the risk of ND in babies. [Paediatr Indones 2008;48:93-
98]. |
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2016-09-15T17:56:38Z |
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