ctrlnum article-613
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Comparison of urine neutrophil gelatinase-associated lipocalin to serum creatinine to assess kidney function in neonatal asphyxia</title><creator>Tanzil, Winston Leonardo</creator><creator>Wilar, Rocky</creator><creator>Mantik, Max Frans Josef</creator><creator>Umboh, Adrian</creator><creator>Tatura, Suryadi Nicolaas Napoleon</creator><description lang="en-US">Background Infants with neonatal asphyxia have multiorgan damage, such as to the kidneys (50%), central nervous system (28%), cardiovascular system (25%), and lungs (23%). Neonatal asphyxia reduces kidney perfusion, often leading to acute kidney injury (AKI) after asphyxia. Neutrophil gelatinase-associated lipocalin (NGAL) levels in the blood, urine and kidney tissue increased rapidly in AKI. Urinary NGAL is proposed to have better performance in diagnosing AKI than creatinine due to its earlier, rapid level increase and it is less invasive.Objective To compare urinary NGAL to serum creatinine as a marker to assess kidney function in neonatal asphyxia.Methods Diagnostic comparison study with cross-sectional design was performed at neonatal intensive care unit (NICU) of Prof. Dr. R. D. Kandou Hospital, Manado from November 2015 to February 2016. All subjects had neonatal asphyxia. Data were analyzed using descriptive analysis, receiver-operator characteristic (ROC) curve, and Z-test.Results Urinary NGAL with cut-off point of 652.24 ng/mL can predict AKI in neonates with asphyxia with 100% sensitivity, 75% specificity, 52.3% positive predictive value, and 100% negative predictive value. Chi-square test resulted in a value of x2 = 20.036, P=0.0001).This shows that urinary NGAL levels &amp;gt;652,24 ng/mL can predicts AKI by 20 times in infants with neonatal asphyxia. So, urinary NGAL performs better than serum creatinine, therefore it can replace serum creatinine as an alternative non-invasive diagnostic test for diagnosing AKI in infants with neonatal asphyxia.Conclusion The diagnostic value of urinary NGAL is higher than that of serum creatinine in assessing kidney function in neonatal asphyxia.&#xA0;</description><publisher lang="en-US">Indonesian Pediatric Society</publisher><date>2017-01-16</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><type>Image:Image</type><type>Document:Document</type><identifier>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613</identifier><identifier>10.14238/pi56.6.2016.356-9</identifier><source lang="en-US">Paediatrica Indonesiana; Vol 56 No 6 (2016): November 2016; 356-9</source><source>2338-476X</source><source>0030-9311</source><source>10.14238/pi56.6.2016</source><language>eng</language><relation>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/pdf</relation><relation>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/1537</relation><relation>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/1538</relation><recordID>article-613</recordID></dc>
language eng
format Journal:Article
Journal
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Other
File:application/pdf
File
Image:Image
Image
Document:Document
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Journal:eArticle
author Tanzil, Winston Leonardo
Wilar, Rocky
Mantik, Max Frans Josef
Umboh, Adrian
Tatura, Suryadi Nicolaas Napoleon
title Comparison of urine neutrophil gelatinase-associated lipocalin to serum creatinine to assess kidney function in neonatal asphyxia
publisher Indonesian Pediatric Society
publishDate 2017
url https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/pdf
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/1537
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/613/1538
contents Background Infants with neonatal asphyxia have multiorgan damage, such as to the kidneys (50%), central nervous system (28%), cardiovascular system (25%), and lungs (23%). Neonatal asphyxia reduces kidney perfusion, often leading to acute kidney injury (AKI) after asphyxia. Neutrophil gelatinase-associated lipocalin (NGAL) levels in the blood, urine and kidney tissue increased rapidly in AKI. Urinary NGAL is proposed to have better performance in diagnosing AKI than creatinine due to its earlier, rapid level increase and it is less invasive.Objective To compare urinary NGAL to serum creatinine as a marker to assess kidney function in neonatal asphyxia.Methods Diagnostic comparison study with cross-sectional design was performed at neonatal intensive care unit (NICU) of Prof. Dr. R. D. Kandou Hospital, Manado from November 2015 to February 2016. All subjects had neonatal asphyxia. Data were analyzed using descriptive analysis, receiver-operator characteristic (ROC) curve, and Z-test.Results Urinary NGAL with cut-off point of 652.24 ng/mL can predict AKI in neonates with asphyxia with 100% sensitivity, 75% specificity, 52.3% positive predictive value, and 100% negative predictive value. Chi-square test resulted in a value of x2 = 20.036, P=0.0001).This shows that urinary NGAL levels &gt;652,24 ng/mL can predicts AKI by 20 times in infants with neonatal asphyxia. So, urinary NGAL performs better than serum creatinine, therefore it can replace serum creatinine as an alternative non-invasive diagnostic test for diagnosing AKI in infants with neonatal asphyxia.Conclusion The diagnostic value of urinary NGAL is higher than that of serum creatinine in assessing kidney function in neonatal asphyxia.
id IOS4351.article-613
institution Ikatan Dokter Anak Indonesia (IDAI)
institution_id 1183
institution_type library:special
library
library Badan Penerbit IDAI
library_id 1030
collection Paediatrica Indonesiana
repository_id 4351
subject_area Pediatric/Pediatrik
Newborn Infant, Neonates/Perawatan Bayi Baru Lahir, Neonatal
city JAKARTA PUSAT
province DKI JAKARTA
repoId IOS4351
first_indexed 2017-07-11T01:01:29Z
last_indexed 2019-06-19T20:45:36Z
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