Your search - " lang="in" xml:lang="in">The oxidation of low-density lipoprotein LDL is believed to be the initiating factor for the development and progression of atherosclerosis. Curcuminoid, the metabolite of Zingiberaceae family such as temu mangga Curcuma mangga, has been shown to reduce the susceptibility of LDL to oxidation. In this study, we examined the effect of curcuminoid extracted from temu mangga on copper ion-induced lipid peroxidation of low density lipoprotein LDL in mice's macrophages and Macaca nemestrina's monocytes. Analyses were done by measuring the formation of thiobarbituric acid reactive substance TBARS as malonaldehyde MDA. LDL were harvested and isolated from 5 adult female Macaca fascicularis fed aterogenic diet for 3 months. LDL oxidation by mice macrophage incubated for 4 hours were inhibited by curcuminoid at concentration of 8 ppm. There was decreased 17% P&lt - did not match any resources.