NEW HOPE ON DRUG LEADS DEVELOPMENT FROM DEEP OCEAN: HALOGENATED ALKALOIDS OF AGELAS SPONGES
| Main Author: | Hertiani, Triana; Department Biology Pharmacy. Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281 |
|---|---|
| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2014
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270/150 |
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article-270 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">NEW HOPE ON DRUG LEADS DEVELOPMENT FROM DEEP OCEAN: HALOGENATED ALKALOIDS OF AGELAS SPONGES</title><creator>Hertiani, Triana; Department Biology Pharmacy. Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281</creator><description lang="en-US">Agelas sponge is found in abundancy from Indonesia’s ocean. This sponge produces an important chemotaxonomic group of compounds, derived from pyrrole-imidazole alkaloids. This group of compounds is one of those exclusively found from marine environment. Marine sponges are reported to be promising drug lead producers having unique chemical structures of which many have no terrestrial counterparts. The objective of this report is to give an overview of the reported attempts from up to down stream to develop pyrrole-imidazole alkaloids as new drug lead. Literatures up to 2013 reporting this group of compounds from Agelas sponges were studied. Discussion on the halogenated alkaloids covers the producers, description of high chemical diversity, identification, biosynthesis and ecological relevance as well as their role as a promising drug candidate. Alternatives to provide continous supplies for drug development are also discussed considering that wild harvesting of the sponge producers can lead to ecological damage in the future . Broad range of interesting pharmacological importance as well as several success in developing synthetic route for production supports its development as drug candidate. </description><publisher lang="en-US">Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia</publisher><contributor lang="en-US"/><date>2014-10-13</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>Other:</type><identifier>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270</identifier><identifier>10.14499/indonesianjpharm25iss4pp199</identifier><source lang="en-US">INDONESIAN JOURNAL OF PHARMACY; Vol 25 No 4, 2014; 199</source><source>2338-9486</source><source>2338-9427</source><language>eng</language><relation>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270/150</relation><rights lang="0">Copyright (c) 2016 INDONESIAN JOURNAL OF PHARMACY</rights><rights lang="0"/><recordID>article-270</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: Journal:eJournal |
| author |
Hertiani, Triana; Department Biology Pharmacy. Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281 |
| title |
NEW HOPE ON DRUG LEADS DEVELOPMENT FROM DEEP OCEAN: HALOGENATED ALKALOIDS OF AGELAS SPONGES |
| publisher |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia |
| publishDate |
2014 |
| url |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/270/150 |
| contents |
Agelas sponge is found in abundancy from Indonesia’s ocean. This sponge produces an important chemotaxonomic group of compounds, derived from pyrrole-imidazole alkaloids. This group of compounds is one of those exclusively found from marine environment. Marine sponges are reported to be promising drug lead producers having unique chemical structures of which many have no terrestrial counterparts. The objective of this report is to give an overview of the reported attempts from up to down stream to develop pyrrole-imidazole alkaloids as new drug lead. Literatures up to 2013 reporting this group of compounds from Agelas sponges were studied. Discussion on the halogenated alkaloids covers the producers, description of high chemical diversity, identification, biosynthesis and ecological relevance as well as their role as a promising drug candidate. Alternatives to provide continous supplies for drug development are also discussed considering that wild harvesting of the sponge producers can lead to ecological damage in the future . Broad range of interesting pharmacological importance as well as several success in developing synthetic route for production supports its development as drug candidate. |
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