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The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats

Main Authors: Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta, Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Format: Article info eJournal
Bahasa: eng
Terbitan: Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia , 2006
Online Access: http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267
ctrlnum article-386
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats</title><creator>Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta</creator><creator>Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta</creator><description lang="en-US">Drug interaction can happen when two or more drugs are given together. This research was aimed to observe the effect of PGV-0 pretreatment to paracetamol pharmacokinetic profile in male rats.The study was conducted employing a one-way randomized completely design, using male Wistar rats weight 150 g (&#xB1;10%). The animals were divided into three groups (5 rats for each group). Group I (control) was given a single oral paracetamol 150 mg/kg BW. The other groups II dan III were given a single oral PGV-0 20 and 40 mg/kg BW one hour before treatment with paracetamol respectively. After all rats were pretreated, serial blood and urine samples were withdrawn and were analysed using HPLC for unchanged paracetamol. Pharmacokinetic parameters of paracetamol i.e. Cmax, tmax, AUC, K, t1/2, Vdss/F, Cl/F, Aecum, dan %fe were determined based on concentration to time data in the blood and urine. The paracetamol pharmacokinetic parameters were analyzed by one-way analysis of varians (ANOVA) using 95% confidence interval. And the difference between groups were analyzed using Tukey-test method. The results showed that the pharmacokinetic parameters of paracetamol in the animals prefed with PGV-0 20 and 40 mg/kg BW did not change significantly (P &amp;gt; 0.05).Key words : pharmacokinetics, interaction, paracetamol, Pentagamavunon-0</description><publisher lang="en-US">Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia</publisher><contributor lang="en-US"/><date>2006-10-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>Other:</type><identifier>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386</identifier><identifier>10.14499/indonesianjpharm0iss0pp194-198</identifier><source lang="en-US">INDONESIAN JOURNAL OF PHARMACY; Vol 17 No 4, 2006; 194-198</source><source>2338-9486</source><source>2338-9427</source><language>eng</language><relation>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267</relation><rights lang="0">Copyright (c) 2016 INDONESIAN JOURNAL OF PHARMACY</rights><rights lang="0"/><recordID>article-386</recordID></dc>
language eng
format Journal:Article
Journal
Other:info:eu-repo/semantics/publishedVersion
Other
Other:
Journal:eJournal
author Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
title The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats
publisher Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
publishDate 2006
url http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267
contents Drug interaction can happen when two or more drugs are given together. This research was aimed to observe the effect of PGV-0 pretreatment to paracetamol pharmacokinetic profile in male rats.The study was conducted employing a one-way randomized completely design, using male Wistar rats weight 150 g (±10%). The animals were divided into three groups (5 rats for each group). Group I (control) was given a single oral paracetamol 150 mg/kg BW. The other groups II dan III were given a single oral PGV-0 20 and 40 mg/kg BW one hour before treatment with paracetamol respectively. After all rats were pretreated, serial blood and urine samples were withdrawn and were analysed using HPLC for unchanged paracetamol. Pharmacokinetic parameters of paracetamol i.e. Cmax, tmax, AUC, K, t1/2, Vdss/F, Cl/F, Aecum, dan %fe were determined based on concentration to time data in the blood and urine. The paracetamol pharmacokinetic parameters were analyzed by one-way analysis of varians (ANOVA) using 95% confidence interval. And the difference between groups were analyzed using Tukey-test method. The results showed that the pharmacokinetic parameters of paracetamol in the animals prefed with PGV-0 20 and 40 mg/kg BW did not change significantly (P &gt; 0.05).Key words : pharmacokinetics, interaction, paracetamol, Pentagamavunon-0
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institution Universitas Gadjah Mada
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collection INDONESIAN JOURNAL OF PHARMACY
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subject_area Farmasi
city SLEMAN
province DAERAH ISTIMEWA YOGYAKARTA
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first_indexed 2016-09-16T19:18:32Z
last_indexed 2016-09-22T21:34:46Z
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