The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats
Main Authors: | Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta, Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta |
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Format: | Article info eJournal |
Bahasa: | eng |
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Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2006
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Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267 |
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article-386 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats</title><creator>Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta</creator><creator>Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta</creator><description lang="en-US">Drug interaction can happen when two or more drugs are given together. This research was aimed to observe the effect of PGV-0 pretreatment to paracetamol pharmacokinetic profile in male rats.The study was conducted employing a one-way randomized completely design, using male Wistar rats weight 150 g (±10%). The animals were divided into three groups (5 rats for each group). Group I (control) was given a single oral paracetamol 150 mg/kg BW. The other groups II dan III were given a single oral PGV-0 20 and 40 mg/kg BW one hour before treatment with paracetamol respectively. After all rats were pretreated, serial blood and urine samples were withdrawn and were analysed using HPLC for unchanged paracetamol. Pharmacokinetic parameters of paracetamol i.e. Cmax, tmax, AUC, K, t1/2, Vdss/F, Cl/F, Aecum, dan %fe were determined based on concentration to time data in the blood and urine. The paracetamol pharmacokinetic parameters were analyzed by one-way analysis of varians (ANOVA) using 95% confidence interval. And the difference between groups were analyzed using Tukey-test method. The results showed that the pharmacokinetic parameters of paracetamol in the animals prefed with PGV-0 20 and 40 mg/kg BW did not change significantly (P &gt; 0.05).Key words : pharmacokinetics, interaction, paracetamol, Pentagamavunon-0</description><publisher lang="en-US">Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia</publisher><contributor lang="en-US"/><date>2006-10-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>Other:</type><identifier>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386</identifier><identifier>10.14499/indonesianjpharm0iss0pp194-198</identifier><source lang="en-US">INDONESIAN JOURNAL OF PHARMACY; Vol 17 No 4, 2006; 194-198</source><source>2338-9486</source><source>2338-9427</source><language>eng</language><relation>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267</relation><rights lang="0">Copyright (c) 2016 INDONESIAN JOURNAL OF PHARMACY</rights><rights lang="0"/><recordID>article-386</recordID></dc>
|
language |
eng |
format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: Journal:eJournal |
author |
Wahyono, Djoko; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta Hakim, Arief Rahman; Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta |
title |
The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats |
publisher |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia |
publishDate |
2006 |
url |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/386/267 |
contents |
Drug interaction can happen when two or more drugs are given together. This research was aimed to observe the effect of PGV-0 pretreatment to paracetamol pharmacokinetic profile in male rats.The study was conducted employing a one-way randomized completely design, using male Wistar rats weight 150 g (±10%). The animals were divided into three groups (5 rats for each group). Group I (control) was given a single oral paracetamol 150 mg/kg BW. The other groups II dan III were given a single oral PGV-0 20 and 40 mg/kg BW one hour before treatment with paracetamol respectively. After all rats were pretreated, serial blood and urine samples were withdrawn and were analysed using HPLC for unchanged paracetamol. Pharmacokinetic parameters of paracetamol i.e. Cmax, tmax, AUC, K, t1/2, Vdss/F, Cl/F, Aecum, dan %fe were determined based on concentration to time data in the blood and urine. The paracetamol pharmacokinetic parameters were analyzed by one-way analysis of varians (ANOVA) using 95% confidence interval. And the difference between groups were analyzed using Tukey-test method. The results showed that the pharmacokinetic parameters of paracetamol in the animals prefed with PGV-0 20 and 40 mg/kg BW did not change significantly (P > 0.05).Key words : pharmacokinetics, interaction, paracetamol, Pentagamavunon-0 |
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IOS1091.article-386 |
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Universitas Gadjah Mada |
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19 |
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Perpustakaan Pusat Universitas Gadjah Mada |
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488 |
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INDONESIAN JOURNAL OF PHARMACY |
repository_id |
1091 |
subject_area |
Farmasi |
city |
SLEMAN |
province |
DAERAH ISTIMEWA YOGYAKARTA |
repoId |
IOS1091 |
first_indexed |
2016-09-16T19:18:32Z |
last_indexed |
2016-09-22T21:34:46Z |
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17.607244 |