Telomere and telomerase in hematological disorders Focusing on bone marrow failure syndromes and hematological malignancies
| Main Authors: | Hardianti, Mardiah Suci, Purwanto, Ibnu, Kurnianda, Johan |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Medicine Universitas Gadjah Mada
, 2016
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| Subjects: | |
| Online Access: |
http://journal.ugm.ac.id/jain/article/view/16928 http://journal.ugm.ac.id/jain/article/view/16928/11132 |
| ctrlnum |
article-16928 |
|---|---|
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Telomere and telomerase in hematological disorders Focusing on bone marrow failure syndromes and hematological malignancies</title><creator>Hardianti, Mardiah Suci</creator><creator>Purwanto, Ibnu</creator><creator>Kurnianda, Johan</creator><subject lang="en-US">telomere; telomerase; bone marrow failure syndromes; hematological malignancies; hematology and medical oncology; internam medicine</subject><description lang="en-US">ABSTRACTWe review the present knowledge of telomeres and telomerase with special attention to their role in hematological disorders especially bone marrow failure syndromes including acquired aplastic anemia and myelodysplastic syndromes, as well as acute and chronic myeloid leukemia. The current understanding on the role of telomere and telomeres dysfunctions in hematological disorders leads us to a better understanding on the pathology of the diseases as well as considering some possibilities to employ the measurement of telomere length and telomere activity in disease prognostication. Several treatment options targeting telomere and telomerase being developed are also reviewed.Keywords: telomere- telomerase- bone marrow failure syndromes- hematological malignancies</description><publisher lang="en-US">Faculty of Medicine Universitas Gadjah Mada</publisher><contributor lang="en-US"/><date>2016-12-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><identifier>http://journal.ugm.ac.id/jain/article/view/16928</identifier><identifier>10.22146/acta interna.16928</identifier><source lang="en-US">Acta Interna: The Journal of Internal Medicine; Vol 4, No 2 (2014): The Journal of Internal Medicine; 87-101</source><source lang="id-ID">Acta Interna The Journal of Internal Medicine; Vol 4, No 2 (2014): The Journal of Internal Medicine; 87-101</source><source>2541-5441</source><source>2303-131X</source><language>eng</language><relation>http://journal.ugm.ac.id/jain/article/view/16928/11132</relation><rights lang="en-US">Copyright (c) 2016 Acta Interna The Journal of Internal Medicine</rights><rights lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</rights><recordID>article-16928</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other File:application/pdf File Journal:eJournal |
| author |
Hardianti, Mardiah Suci Purwanto, Ibnu Kurnianda, Johan |
| title |
Telomere and telomerase in hematological disorders Focusing on bone marrow failure syndromes and hematological malignancies |
| publisher |
Faculty of Medicine Universitas Gadjah Mada |
| publishDate |
2016 |
| topic |
telomere telomerase bone marrow failure syndromes hematological malignancies hematology and medical oncology internam medicine |
| url |
http://journal.ugm.ac.id/jain/article/view/16928 http://journal.ugm.ac.id/jain/article/view/16928/11132 |
| contents |
ABSTRACTWe review the present knowledge of telomeres and telomerase with special attention to their role in hematological disorders especially bone marrow failure syndromes including acquired aplastic anemia and myelodysplastic syndromes, as well as acute and chronic myeloid leukemia. The current understanding on the role of telomere and telomeres dysfunctions in hematological disorders leads us to a better understanding on the pathology of the diseases as well as considering some possibilities to employ the measurement of telomere length and telomere activity in disease prognostication. Several treatment options targeting telomere and telomerase being developed are also reviewed.Keywords: telomere- telomerase- bone marrow failure syndromes- hematological malignancies |
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Universitas Gadjah Mada |
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Perpustakaan Pusat Universitas Gadjah Mada |
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Jurnal Acta Interna |
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1229 |
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SLEMAN |
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DAERAH ISTIMEWA YOGYAKARTA |
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