STUDI PERBANDINGAN PENGOBATAN HALOFANTRIN ANTARA PENDERITA MALARIA FALSIPARUM TANPA KOMPLIKASI YANG IN VITRO SENSITIF DENGAN YANG RESISTEN KLOROKUIN
| Main Authors: | Tjitra, Emiliana; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI, Oemijati, Sri; Bagian Parasitologi, FKUI, Jakarta, Pribadi, Wita; Bagian Parasitologi, FKUI, Jakarta, Arbadi, P. R.; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI, Romzan, Ali; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI, Renny, Marvel; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI, Marwoto, Hariyani; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI |
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| Other Authors: | BADAN LITBANGKES KEMENKES |
| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Badan Penelitian dan Pengembangan Kesehatan
, 2012
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| Subjects: | |
| Online Access: |
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/412 |
| ctrlnum |
article-412 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="id-ID">STUDI PERBANDINGAN PENGOBATAN HALOFANTRIN ANTARA PENDERITA MALARIA FALSIPARUM TANPA KOMPLIKASI YANG IN VITRO SENSITIF DENGAN YANG RESISTEN KLOROKUIN</title><creator>Tjitra, Emiliana; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI</creator><creator>Oemijati, Sri; Bagian Parasitologi, FKUI, Jakarta</creator><creator>Pribadi, Wita; Bagian Parasitologi, FKUI, Jakarta</creator><creator>Arbadi, P. R.; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI</creator><creator>Romzan, Ali; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI</creator><creator>Renny, Marvel; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI</creator><creator>Marwoto, Hariyani; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI</creator><subject lang="id-ID">Health; Kesehatan</subject><subject lang="id-ID">Falciparum Malaria; Halofantrine; Chloroquine</subject><subject lang="id-ID"/><description lang="id-ID">Halofantrine study on uncomplicated falciparum malaria patients was carried out at ITCI hospital in Balikpapan, East Kalimantan, Indonesia in 1990-1991. This study was conducted to compare the efficacy and safety of halofantrine on in vitro sensitive and resistant chloroquine falciparum malaria patients. Of the 80 patients selected according to WHO criteria for in vivo and in vitro drug sensitivity test and treated orally with 500 mg halofantrine 6 hourly for 3 doses, only 46 patients could be further analized as the in vitro sensitive group (19) and resistant group (27). On admission, no significant different findings were noted in characteristics, clinical symptoms and signs, hematological and biochemical parameters between the sensitive and resistant groups except thrombocyte and creatinine. Clinical symptoms more frequently encountered were headache (92,6-100%), fever (789- 92,6%), chills (78,9-85,2%) and nausea or/and vomiting (57,9-63%). There were no significant differences between the sensitive and resistant groups in cure rate (100% and 96,3%), fever clearance time (17,1 ± 3,5 h and 21,8 ± 4,6 h) and parasite clearance time (51,6 ± 2,8 h and 66,9 ± 12,1 h). When the patients were discharged, the hematological and biochemical parameters showed normal values, except thrombocyte, but the differences between those groups were insignificant. This study showed that halofantrine is effective and safe both for treatment on in vitro sensitive chloroquine falciparum malaria patients and for treatment on in vitro resistant chloroquine falciparum malaria patients.</description><publisher lang="en-US">Badan Penelitian dan Pengembangan Kesehatan</publisher><contributor lang="id-ID">BADAN LITBANGKES KEMENKES</contributor><date>2012-09-11</date><type>Other:</type><type>File:application/pdf</type><identifier>http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/412</identifier><source lang="id-ID">Buletin Penelitian Kesehatan; Vol 21, No 1 Mar (1993)</source><source lang="en-US">Buletin Penelitian Kesehatan; Vol 21, No 1 Mar (1993)</source><language>ind</language><rights>The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.</rights><recordID>article-412</recordID></dc>
|
| language |
ind |
| format |
Other: Other File:application/pdf File Journal:eJournal Journal |
| author |
Tjitra, Emiliana; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI Oemijati, Sri; Bagian Parasitologi, FKUI, Jakarta Pribadi, Wita; Bagian Parasitologi, FKUI, Jakarta Arbadi, P. R.; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI Romzan, Ali; Direktorat Jenderal PPM-PLP, Departemen Kesehatan RI Renny, Marvel; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI Marwoto, Hariyani; Badan Penelitian dan Pengembangan Kesehatan, Depkes RI |
| author2 |
BADAN LITBANGKES KEMENKES |
| title |
STUDI PERBANDINGAN PENGOBATAN HALOFANTRIN ANTARA PENDERITA MALARIA FALSIPARUM TANPA KOMPLIKASI YANG IN VITRO SENSITIF DENGAN YANG RESISTEN KLOROKUIN |
| publisher |
Badan Penelitian dan Pengembangan Kesehatan |
| publishDate |
2012 |
| topic |
Health Kesehatan Falciparum Malaria Halofantrine Chloroquine |
| url |
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/412 |
| contents |
Halofantrine study on uncomplicated falciparum malaria patients was carried out at ITCI hospital in Balikpapan, East Kalimantan, Indonesia in 1990-1991. This study was conducted to compare the efficacy and safety of halofantrine on in vitro sensitive and resistant chloroquine falciparum malaria patients. Of the 80 patients selected according to WHO criteria for in vivo and in vitro drug sensitivity test and treated orally with 500 mg halofantrine 6 hourly for 3 doses, only 46 patients could be further analized as the in vitro sensitive group (19) and resistant group (27). On admission, no significant different findings were noted in characteristics, clinical symptoms and signs, hematological and biochemical parameters between the sensitive and resistant groups except thrombocyte and creatinine. Clinical symptoms more frequently encountered were headache (92,6-100%), fever (789- 92,6%), chills (78,9-85,2%) and nausea or/and vomiting (57,9-63%). There were no significant differences between the sensitive and resistant groups in cure rate (100% and 96,3%), fever clearance time (17,1 ± 3,5 h and 21,8 ± 4,6 h) and parasite clearance time (51,6 ± 2,8 h and 66,9 ± 12,1 h). When the patients were discharged, the hematological and biochemical parameters showed normal values, except thrombocyte, but the differences between those groups were insignificant. This study showed that halofantrine is effective and safe both for treatment on in vitro sensitive chloroquine falciparum malaria patients and for treatment on in vitro resistant chloroquine falciparum malaria patients. |
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