Pengaruh Pemberian Ekstrak Biji Parkia speciosa terhadap Gambaran Histopatologi Ginjal Bagian Tubulus Proksimal Pada Tikus Putih Jantan yang Diinduksi Paracetamol
| Main Author: | DEVIANA, AVINDA; Faculty of Medicine Hang Tuah University |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Universitas Hang Tuah
, 2018
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| Subjects: | |
| Online Access: |
http://journal-medical.hangtuah.ac.id/index.php/jurnal1/article/view/Deviana http://journal-medical.hangtuah.ac.id/index.php/jurnal1/article/view/Deviana/53 |
Daftar Isi:
- Paracetamol, which is one of the NSAIDs (Non Steroidal Anti Inflammatory Drugs) is widely used by the wider community as a therapeutic and pain-reducing therapy. In addition to its many uses, paracetamol can cause a variety of serious toxicities, including nephrotoxicity. Bitter bean extract (Parkia speciosa) has a flavonoid compound which is an antioxidant. This was a laboratory experimental study with post-test only control group design using 24 rats divided into 3 groups. Positive control group fed with standard diet, aquades and bitter bean extract (Parkia speciosa); each rat in the treatment group 1 was induced with paracetamol 9 mg / day orally; and each rat in the treatment group 2 was given bitter bean extract (Parkia speciosa) 7,2 mg / day induced paracetamol 9 mg / day after 45 min. The kidneys were taken by surgery on the 15th day and microscopically examined. The data were analyzed using IBM SPSS version 23 with Kruskal-Wallis method.