Molecular Docking Approach of Viscosin as Antibacterial for Methicillin-resistant Staphylococcus Aureus Via Î2-Lactamase Inhibitor Mechanism
| Main Authors: | Syaban, Mokhamad Fahmi Rizki, Erwan, Nabila Erina, Raihan Syamsuddin, Muhammad Rafif, Zahra, Fatimah Az, Sabila, Faradilah Lukmana |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Brawijaya
, 2021
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| Subjects: | |
| Online Access: |
https://crjim.ub.ac.id/index.php/crjim/article/view/87 https://crjim.ub.ac.id/index.php/crjim/article/view/87/90 |
Daftar Isi:
- Background: Î2-lactamase is an enzyme that plays a role in the occurrence of antibiotic resistance against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Viscosin is a lipopeptide biosurfactant produced by the Pseudomonas group bacteria. A study states that Viscosin has strong antibacterial properties.Aims: This study aims to determine the interactions that occur with Viscosin and Î2-lactamase enzymes.Methods: Researchers used the in-silico method to determine the molecular interactions that occurred computationally. The protein used was Î2-lactamase protein obtained from the Protein Data Bank and Viscosin ligand obtained from the PubChem web server, and we used native ligands as control. Pharma expert web server and Pyrx, Pymol, and Discovery Studio software were used in this research.Results: The results showed that Viscosin has high activity as an antibiotic and is predicted to be a membrane integrity antagonist. The binding affinity interaction that occurs between Viscosin-Î2-lactamase is -7.3 kcal/mol. The affinity is lower than the control.Conclusion: Viscosin was predicted to have strong antibacterial properties, but the binding interaction was lower than the control. However, exploration of Viscosin compounds and further research to determine the antibacterial effect of Viscosin against MRSA and other bacteria is needed to against antibiotic resistance.