EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH
| Main Authors: | Maysara, Risha; Fakultas Farmasi UAD, Yuliani, Sapto; Fakultas Farmasi UAD |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Ahmad Dahlan
, 2011
|
| Subjects: | |
| Online Access: |
http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521 http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521/344 |
| ctrlnum |
article-521 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH</title><creator>Maysara, Risha; Fakultas Farmasi UAD</creator><creator>Yuliani, Sapto; Fakultas Farmasi UAD</creator><subject lang="en-US">lycopene; paracetamol; alanine aminotransferase activity</subject><description lang="en-US">Liver is one of the most important organ for drug metabolism in the body. Thedamage to the liver can be marked by increased activity of the enzyme alanineaminotransferase (ALT) in the blood. Lycopene is an antioxidant that has the ability toeliminate free radicals and detoxifies electrophilic compounds that damage can beprevented. The purpose of this research is to know whether lycopene can inhibit theincrease alanine aminotransferase activity of SD (Sprague Dawley) rats induced byparasetamol. This experiment using 20 male rats Sprague Dawley. They were dividedinto 4 groups. Group I is a healthy control (baseline) was only given aquadest, group IIwere given paracetamol as pain control, group III and IV are treatment group wereeach given lycopene with a dosage 15 µg/kg BW and 30 µg/kg BW for 21 days. On 19thday group II, as well as all treatment groups induced paracetamol. The blood samplingwas performed on orbital sinus on 19th day (before induced by paracetamol) and on 21thday or two days after induced paracetamol to know the difference alanineaminotransferase activity. The data were analyzed using non-parametric statisticalmethods with Kruskal-Wallis test followed by Mann-Whitney test with 95% confidencelevel. The result has showed that the lycopene doses 15 µg/kgBW had alanineaminotransferase activity of 130.10 ± 11.83 U/I and lycopene doses 30 µg/kgBW hadalanine aminotransferase activity of 106.46 ± 2.36 U/I. If compared with paracetamolcontrol had alanine aminotransferase activity of 92.53 ± 2.57 U/I, should take asummary that the lycopene doses 15 ìg/kg BW and 30 ìg/kg BW couldn’t decreasealanine aminotransferase activity on SD (Sprague Dawley) male rats.</description><publisher lang="en-US">Universitas Ahmad Dahlan</publisher><contributor lang="en-US"/><date>2011-11-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521</identifier><identifier>10.12928/pharmaciana.v1i2.521</identifier><source lang="en-US">Pharmaciana; Vol 1, No 2 (2011): Pharmaciana</source><source>2477-0256</source><source>2088-4559</source><source>10.12928/pharmaciana.v1i2</source><language>eng</language><relation>http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521/344</relation><relation>10.12928/pharmaciana.v1i2.521.g344</relation><rights lang="0">Copyright (c) 2016 Pharmaciana</rights><rights lang="0">http://creativecommons.org/licenses/by-nc-sa/4.0</rights><recordID>article-521</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Journal:eJournal |
| author |
Maysara, Risha; Fakultas Farmasi UAD Yuliani, Sapto; Fakultas Farmasi UAD |
| title |
EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH |
| publisher |
Universitas Ahmad Dahlan |
| publishDate |
2011 |
| topic |
lycopene paracetamol alanine aminotransferase activity |
| url |
http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521 http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/521/344 |
| contents |
Liver is one of the most important organ for drug metabolism in the body. Thedamage to the liver can be marked by increased activity of the enzyme alanineaminotransferase (ALT) in the blood. Lycopene is an antioxidant that has the ability toeliminate free radicals and detoxifies electrophilic compounds that damage can beprevented. The purpose of this research is to know whether lycopene can inhibit theincrease alanine aminotransferase activity of SD (Sprague Dawley) rats induced byparasetamol. This experiment using 20 male rats Sprague Dawley. They were dividedinto 4 groups. Group I is a healthy control (baseline) was only given aquadest, group IIwere given paracetamol as pain control, group III and IV are treatment group wereeach given lycopene with a dosage 15 μg/kg BW and 30 μg/kg BW for 21 days. On 19thday group II, as well as all treatment groups induced paracetamol. The blood samplingwas performed on orbital sinus on 19th day (before induced by paracetamol) and on 21thday or two days after induced paracetamol to know the difference alanineaminotransferase activity. The data were analyzed using non-parametric statisticalmethods with Kruskal-Wallis test followed by Mann-Whitney test with 95% confidencelevel. The result has showed that the lycopene doses 15 μg/kgBW had alanineaminotransferase activity of 130.10 ± 11.83 U/I and lycopene doses 30 μg/kgBW hadalanine aminotransferase activity of 106.46 ± 2.36 U/I. If compared with paracetamolcontrol had alanine aminotransferase activity of 92.53 ± 2.57 U/I, should take asummary that the lycopene doses 15 ìg/kg BW and 30 ìg/kg BW couldn’t decreasealanine aminotransferase activity on SD (Sprague Dawley) male rats. |
| id |
IOS160.article-521 |
| institution |
Universitas Ahmad Dahlan |
| institution_id |
62 |
| institution_type |
library:university library |
| library |
Perpustakaan Universitas Ahmad Dahlan |
| library_id |
467 |
| collection |
Bulletin of Electrical Engineering and Informatics |
| repository_id |
160 |
| subject_area |
Rekayasa |
| city |
KOTA YOGYAKARTA |
| province |
DAERAH ISTIMEWA YOGYAKARTA |
| repoId |
IOS160 |
| first_indexed |
2016-09-22T19:13:35Z |
| last_indexed |
2017-02-25T09:00:23Z |
| recordtype |
dc |
| merged_child_boolean |
1 |
| _version_ |
1685780938789748736 |
| score |
17.610533 |