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PENGARUH PEMBERIAN AKAR PASAK BUMI (Eurycoma longifolia Jack.) TERHADAP KERUSAKAN ORGAN HATI MENCIT BUNTING (The Effect of Eurycoma longifolia Jack. Roots on Liver Damage of Pregnant Mice)

Main Authors: Panjaitan, Ruqiah Ganda Putri, M, Masriani, Z, Zulfan
Format: Article info application/pdf eJournal
Bahasa: eng
Terbitan: Syiah Kuala University , 2016
Online Access: http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366
http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366/3155
ctrlnum article-3366
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">PENGARUH PEMBERIAN AKAR PASAK BUMI (Eurycoma longifolia Jack.) TERHADAP KERUSAKAN ORGAN HATI MENCIT BUNTING (The Effect of Eurycoma longifolia Jack. Roots on Liver Damage of Pregnant Mice)</title><creator>Panjaitan, Ruqiah Ganda Putri</creator><creator>M, Masriani</creator><creator>Z, Zulfan</creator><subject lang="en-US"/><description lang="en-US">This study aims to find out the eeffect of Eurycoma longifolia Jack. roots on the liver damage of pregnant mice. This research used Balb/cstrain mice, 2-3 month, with the weight ranging of 27-33 gram. Samples were divided into three treatment groups consisted of three mice. GroupI (KI) was negative control (placebo), only treated with 0.06 ml/20 g bw of distilled water, group II (KII) was administered with roots ofEurycoma longifolia Jack extract at dose of 14 mg/20 g bw, and group III (KIII, positive control) was administered with Schizandrae at the dose0.06 mg/20 g bw. Treatment were done for 7 consecutive days in pregnancy period. On day 8th, blood samples were collected to examine the levelof alanine transaminase (AST) and aspartate transaminase (ALT) enzymes in serum and liver organ were collected to observe thehistopathological changes. The average of ALT and AST enzymes level on K1, K2, and K3 were 18.34+0.28, 19.68+0.15, and 19.20+0.08 U/l; and21.79+0.26, 23.42+0.41, and 22.23+0.52 U/l. The histopathological examination results showed that the administration of E. longifolia Jackroots extract and Schizandrae reveal the karyomegali and fatty change of hepatocytes. It is concluded that the administration of E. longifoliaJack roots extract at the dose of 14 mg/20 g bw could decrease the liver function of pregnant mice. Key words: Eurycoma longfolia Jack. root, pregnancy period, liver histopathological studies&#xA0;</description><publisher lang="en-US">Syiah Kuala University</publisher><contributor lang="en-US"/><date>2016-03-15</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><identifier>http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366</identifier><identifier>10.21157/j.ked.hewan.v10i1.3366</identifier><source lang="en-US">Jurnal Kedokteran Hewan; Vol 10, No 1 (2016): J. Ked. Hewan; 28-31</source><source lang="id-ID">Jurnal Kedokteran Hewan; Vol 10, No 1 (2016): J. Ked. Hewan; 28-31</source><source>2502-5600</source><source>1978-225X</source><language>eng</language><relation>http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366/3155</relation><rights lang="en-US">Copyright (c) 2016 by author and J. Ked. Hewan</rights><rights lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</rights><recordID>article-3366</recordID></dc>
language eng
format Journal:Article
Journal
Other:info:eu-repo/semantics/publishedVersion
Other
File:application/pdf
File
Journal:eJournal
author Panjaitan, Ruqiah Ganda Putri
M, Masriani
Z, Zulfan
title PENGARUH PEMBERIAN AKAR PASAK BUMI (Eurycoma longifolia Jack.) TERHADAP KERUSAKAN ORGAN HATI MENCIT BUNTING (The Effect of Eurycoma longifolia Jack. Roots on Liver Damage of Pregnant Mice)
publisher Syiah Kuala University
publishDate 2016
url http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366
http://www.jurnal.unsyiah.ac.id/JKH/article/view/3366/3155
contents This study aims to find out the eeffect of Eurycoma longifolia Jack. roots on the liver damage of pregnant mice. This research used Balb/cstrain mice, 2-3 month, with the weight ranging of 27-33 gram. Samples were divided into three treatment groups consisted of three mice. GroupI (KI) was negative control (placebo), only treated with 0.06 ml/20 g bw of distilled water, group II (KII) was administered with roots ofEurycoma longifolia Jack extract at dose of 14 mg/20 g bw, and group III (KIII, positive control) was administered with Schizandrae at the dose0.06 mg/20 g bw. Treatment were done for 7 consecutive days in pregnancy period. On day 8th, blood samples were collected to examine the levelof alanine transaminase (AST) and aspartate transaminase (ALT) enzymes in serum and liver organ were collected to observe thehistopathological changes. The average of ALT and AST enzymes level on K1, K2, and K3 were 18.34+0.28, 19.68+0.15, and 19.20+0.08 U/l; and21.79+0.26, 23.42+0.41, and 22.23+0.52 U/l. The histopathological examination results showed that the administration of E. longifolia Jackroots extract and Schizandrae reveal the karyomegali and fatty change of hepatocytes. It is concluded that the administration of E. longifoliaJack roots extract at the dose of 14 mg/20 g bw could decrease the liver function of pregnant mice. Key words: Eurycoma longfolia Jack. root, pregnancy period, liver histopathological studies
id IOS1618.article-3366
institution Universitas Syiah Kuala
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library Perpustakaan Universitas Syiah Kuala
library_id 603
collection Jurnal Kedokteran Hewan
repository_id 1618
subject_area Peternakan
city KOTA BANDA ACEH
province ACEH
repoId IOS1618
first_indexed 2016-09-22T18:58:45Z
last_indexed 2016-09-24T07:38:30Z
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