Pengaruh Pemberian Omeprazole terhadap Kejadian Ventilator-Associated Pneumonia pada Pasien PICU di RSUPN Dr. Ciptomangunkusumo = The Effect of Omeprazole on Incidence of Ventilator-Associated Pneumonia among RSUPN Dr. Ciptomangunkusumo PICU Patients

Main Author: Koe Stella Asadinia
Format: Book xiv, 35 hlm., 21cm x 30cm
Bahasa: ind
Terbitan: Program Pendidikan Dokter Umum S1 Reguler , 2017
Subjects:
VAP
Online Access: http://perpustakaan.fk.ui.ac.id/new-opac/index.php?p=show_detail&id=23659
ctrlnum slims-23659
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>Pengaruh Pemberian Omeprazole terhadap Kejadian Ventilator-Associated Pneumonia pada Pasien PICU di RSUPN Dr. Ciptomangunkusumo = The Effect of Omeprazole on Incidence of Ventilator-Associated Pneumonia among RSUPN Dr. Ciptomangunkusumo PICU Patients.</title><creator>Koe Stella Asadinia</creator><subject>PICU</subject><subject>ventilator-associated pneumonia</subject><subject>VAP</subject><subject>Omeprazole</subject><publisher>Program Pendidikan Dokter Umum S1 Reguler</publisher><date>2017</date><language>ind</language><type>Book:Book</type><identifier>http://perpustakaan.fk.ui.ac.id/new-opac/index.php?p=show_detail&amp;id=23659</identifier><identifier>S17122fk</identifier><description>Latar belakang: Ventilator-associated pneumonia (VAP) merupakan jenis infeksi nosokomial terbanyak pada pasien pediatric intensive care unit (PICU). VAP menyebabkan pemanjangan durasi ventilasi mekanik, durasi hospitalisasi, dan kematian. Omeprazole direkomendasikan sebagai profilaksis dan pengobatan stress ulcer pada pasien PICU dengan ventilator. Omeprazole diduga dapat meningkatkan kejadian VAP melalui peningkatan kolonisasi bakteri lambung. Namun, belum banyak studi yang meneliti pengaruh ini pada populasi pasien PICU. Tujuan: Mengetahui pengaruh pemberian omeprazole terhadap kejadian VAP pada Pasien PICU di RSUPN Dr. Ciptomangunkusumo. Metode: Studi ini dilaksanakan dengan metode cross-sectional dengan 58 subjek. Sampel diambil dari rekam medis pasien PICU tahun 2014 hingga 2016. Subjek terdiri dari dua kelompok, yaitu pasien PICU dengan ventilator yang diberi omeprazole dan tidak diberi omeprazole. Hasil: Karakteristik subjek meliputi jenis kelamin, usia, status gizi, faktor risiko potensial, dan keluaran berupa durasi hospitalisasi, durasi intubasi, dan kematian. Sejumlah 9 dari 29 (31%) subjek yang diberi omeprazole mengalami VAP dan 3 dari 29 (10%) subjek yang tidak diberi omeprazole mengalami VAP. Uji Chi-square menunjukkan hubungan tidak bermakna antara omeprazole dan kejadian VAP dengan nilai p=0.105 dan prevalence ratio (PR) 3.00 (95% CI 0.903-9.970). Diskusi: Hasil penelitian ini menyatakan bahwa pemberian omeprazole tidak berpengaruh terhadap kejadian VAP pada pasien PICU. Kata kunci: Omeprazole, PICU, PPI, proton pump inhibitor, ventilator-associated pneumonia, VAP Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection among pediatric intensive care unit (PICU) patients. VAP prolongs duration of intubation and hospitalization and increases mortality. Omeprazole is often used as prophylaxis and therapy for stress ulcer, a common disease in PICU patients. Omeprazole is suspected to increase VAP incidence through gastric colonization. Aim: To determine the effect of omeprazole on incidence of ventilator-associated pneumonia among RSUPN Dr. Ciptomangunkusumo PICU Patients. Methods: This is a cross-sectional study with 58 subjects obtained from PICU medical records from 2014 to 2016. Subjects were put into two categories: (1) PICU patients who received omeprazole, and (2) PICU patients who did not receive omeprazole. Results: Subject characteristics include sex, age, nutritional status, potential risk factors, and outcome (duration of hospitalization, duration of intubation and mortality). A number of 9 of 29 (31%) patients who received omeprazole developed VAP and 3 of 29 (10%) patients who did not receive omeprazole developed VAP. Chi-square test showed no significant difference in the incidence of VAP in the two categories (p=0.105) and prevalence ratio (PR) 3.00 (95% CI 0.903-9.970). Discussion: Omeprazole does not affect the incidence of VAP on PICU patients in this study.Key words: Omeprazole, PICU, ventilator-associated pneumonia, VAP</description><coverage>Jakarta</coverage><type>Other:xiv, 35 hlm., 21cm x 30cm</type><subject>NONE</subject><image>http://perpustakaan.fk.ui.ac.id/new-opac/images/default/image.png</image><recordID>slims-23659</recordID></dc>
language ind
format Book:Book
Book
Other:xiv, 35 hlm., 21cm x 30cm
Other
author Koe Stella Asadinia
title Pengaruh Pemberian Omeprazole terhadap Kejadian Ventilator-Associated Pneumonia pada Pasien PICU di RSUPN Dr. Ciptomangunkusumo = The Effect of Omeprazole on Incidence of Ventilator-Associated Pneumonia among RSUPN Dr. Ciptomangunkusumo PICU Patients
publisher Program Pendidikan Dokter Umum S1 Reguler
publishDate 2017
topic PICU
ventilator-associated pneumonia
VAP
Omeprazole
NONE
url http://perpustakaan.fk.ui.ac.id/new-opac/index.php?p=show_detail&id=23659
contents Latar belakang: Ventilator-associated pneumonia (VAP) merupakan jenis infeksi nosokomial terbanyak pada pasien pediatric intensive care unit (PICU). VAP menyebabkan pemanjangan durasi ventilasi mekanik, durasi hospitalisasi, dan kematian. Omeprazole direkomendasikan sebagai profilaksis dan pengobatan stress ulcer pada pasien PICU dengan ventilator. Omeprazole diduga dapat meningkatkan kejadian VAP melalui peningkatan kolonisasi bakteri lambung. Namun, belum banyak studi yang meneliti pengaruh ini pada populasi pasien PICU. Tujuan: Mengetahui pengaruh pemberian omeprazole terhadap kejadian VAP pada Pasien PICU di RSUPN Dr. Ciptomangunkusumo. Metode: Studi ini dilaksanakan dengan metode cross-sectional dengan 58 subjek. Sampel diambil dari rekam medis pasien PICU tahun 2014 hingga 2016. Subjek terdiri dari dua kelompok, yaitu pasien PICU dengan ventilator yang diberi omeprazole dan tidak diberi omeprazole. Hasil: Karakteristik subjek meliputi jenis kelamin, usia, status gizi, faktor risiko potensial, dan keluaran berupa durasi hospitalisasi, durasi intubasi, dan kematian. Sejumlah 9 dari 29 (31%) subjek yang diberi omeprazole mengalami VAP dan 3 dari 29 (10%) subjek yang tidak diberi omeprazole mengalami VAP. Uji Chi-square menunjukkan hubungan tidak bermakna antara omeprazole dan kejadian VAP dengan nilai p=0.105 dan prevalence ratio (PR) 3.00 (95% CI 0.903-9.970). Diskusi: Hasil penelitian ini menyatakan bahwa pemberian omeprazole tidak berpengaruh terhadap kejadian VAP pada pasien PICU. Kata kunci: Omeprazole, PICU, PPI, proton pump inhibitor, ventilator-associated pneumonia, VAP Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection among pediatric intensive care unit (PICU) patients. VAP prolongs duration of intubation and hospitalization and increases mortality. Omeprazole is often used as prophylaxis and therapy for stress ulcer, a common disease in PICU patients. Omeprazole is suspected to increase VAP incidence through gastric colonization. Aim: To determine the effect of omeprazole on incidence of ventilator-associated pneumonia among RSUPN Dr. Ciptomangunkusumo PICU Patients. Methods: This is a cross-sectional study with 58 subjects obtained from PICU medical records from 2014 to 2016. Subjects were put into two categories: (1) PICU patients who received omeprazole, and (2) PICU patients who did not receive omeprazole. Results: Subject characteristics include sex, age, nutritional status, potential risk factors, and outcome (duration of hospitalization, duration of intubation and mortality). A number of 9 of 29 (31%) patients who received omeprazole developed VAP and 3 of 29 (10%) patients who did not receive omeprazole developed VAP. Chi-square test showed no significant difference in the incidence of VAP in the two categories (p=0.105) and prevalence ratio (PR) 3.00 (95% CI 0.903-9.970). Discussion: Omeprazole does not affect the incidence of VAP on PICU patients in this study.Key words: Omeprazole, PICU, ventilator-associated pneumonia, VAP
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