A RESEARCH STUDY ON EFFECTS OF ANTI HEPATITIS C VIRUS AND HBsAg ON α-FETOPROTEIN IN CLD ADDICTED PATIENTS: EFFECT OF SERUM ALPHA FETOPROTEIN FOR IDENTIFICATION OF HEPATOCELLULAR CARCINOMA
| Main Author: | Dr. Ammara Tariq, Kiran Irshad, Dr. Anum Shafique |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1450806 |
| ctrlnum |
1450806 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Dr. Ammara Tariq, Kiran Irshad, Dr. Anum Shafique</creator><date>2018-10-07</date><description>Objective: Research was held to get knowledge about the effect of serum alpha fetoprotein for identification of Hepatocellular carcinoma.
Study Design: Case Control Study (CCS).
Place and Duration of Study: Current case control research study was accomplished in the period of 12 months from May 2016 to April 2017 at Gastroenterology and Hepatology Department of Services Hospital Shadman Road, Lahore.
Material and Methods: 170 CLD patients and 130 HCC cases were included in the research paper as sample calculated by the WHO recognized calculator. Calculated the positive predictive values (PPV), negative predictive values (NPV), Sensitivity, specificity, CLD status, gender, age, HBsAg and anti-HCV statuses of patients as it was a matched case control study. examined PPV and NPV for three (6%, 11% and 20%) HCC supplementary augmentations.
Results: The value of 21 ng / ml has a comparable specificity as 89.6% Vs 89.4% and sensitivity as 60% Vs 62% and 17 ng / ml was the utmost distinctive AFP level. Above 21 ng / ml must be examined for HCC patients. The tumor fell to 26.1% with a rate of 5% when positive predictive value (PPV) was 20ng/ml (85%). Negative predictive value (NPV) was at 70% and with rate of 5% augmented to 98.07%. With percentage rate of 5 percent NPV deviate from 58.90 percent to 72.90 percent. It was observed that PPV of HCC infected patients in different groups varied with a rate of 5% from 81 percent to 91 percent. With any HCC incidence PPV was 100% in any uninfected patient.
Conclusion: After examining AFP results it was found that the risk of cancer (HCC) rises in the majority of the patients infected by CLD that can be monitored through this test. Rise in AFP levels is the symptoms of HCC for uninfected people.
Keywords: Hepatocellular carcinoma (HCC), chronic liver disease (CLD), α-Fetoprotein (AFP)</description><identifier>https://zenodo.org/record/1450806</identifier><identifier>10.5281/zenodo.1450806</identifier><identifier>oai:zenodo.org:1450806</identifier><language>eng</language><relation>doi:10.5281/zenodo.1450805</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/licenses/by/4.0/legalcode</rights><source>INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05(10) 9604-9611</source><subject>Hepatocellular carcinoma (HCC), chronic liver disease (CLD), α-Fetoprotein (AFP)</subject><title>A RESEARCH STUDY ON EFFECTS OF ANTI HEPATITIS C VIRUS AND HBsAg ON α-FETOPROTEIN IN CLD ADDICTED PATIENTS: EFFECT OF SERUM ALPHA FETOPROTEIN FOR IDENTIFICATION OF HEPATOCELLULAR CARCINOMA</title><type>Journal:Article</type><type>Journal:Article</type><recordID>1450806</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal |
| author |
Dr. Ammara Tariq, Kiran Irshad, Dr. Anum Shafique |
| title |
A RESEARCH STUDY ON EFFECTS OF ANTI HEPATITIS C VIRUS AND HBsAg ON α-FETOPROTEIN IN CLD ADDICTED PATIENTS: EFFECT OF SERUM ALPHA FETOPROTEIN FOR IDENTIFICATION OF HEPATOCELLULAR CARCINOMA |
| publishDate |
2018 |
| topic |
Hepatocellular carcinoma (HCC) chronic liver disease (CLD) α-Fetoprotein (AFP) |
| url |
https://zenodo.org/record/1450806 |
| contents |
Objective: Research was held to get knowledge about the effect of serum alpha fetoprotein for identification of Hepatocellular carcinoma.
Study Design: Case Control Study (CCS).
Place and Duration of Study: Current case control research study was accomplished in the period of 12 months from May 2016 to April 2017 at Gastroenterology and Hepatology Department of Services Hospital Shadman Road, Lahore.
Material and Methods: 170 CLD patients and 130 HCC cases were included in the research paper as sample calculated by the WHO recognized calculator. Calculated the positive predictive values (PPV), negative predictive values (NPV), Sensitivity, specificity, CLD status, gender, age, HBsAg and anti-HCV statuses of patients as it was a matched case control study. examined PPV and NPV for three (6%, 11% and 20%) HCC supplementary augmentations.
Results: The value of 21 ng / ml has a comparable specificity as 89.6% Vs 89.4% and sensitivity as 60% Vs 62% and 17 ng / ml was the utmost distinctive AFP level. Above 21 ng / ml must be examined for HCC patients. The tumor fell to 26.1% with a rate of 5% when positive predictive value (PPV) was 20ng/ml (85%). Negative predictive value (NPV) was at 70% and with rate of 5% augmented to 98.07%. With percentage rate of 5 percent NPV deviate from 58.90 percent to 72.90 percent. It was observed that PPV of HCC infected patients in different groups varied with a rate of 5% from 81 percent to 91 percent. With any HCC incidence PPV was 100% in any uninfected patient.
Conclusion: After examining AFP results it was found that the risk of cancer (HCC) rises in the majority of the patients infected by CLD that can be monitored through this test. Rise in AFP levels is the symptoms of HCC for uninfected people.
Keywords: Hepatocellular carcinoma (HCC), chronic liver disease (CLD), α-Fetoprotein (AFP) |
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