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Dataset related to article "Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis"

Main Authors: Navarria, Pierina, Pessina, Federico, Franzese, Ciro, Tomatis, Stefano Maria, Perrino, Matteo Romualdo Anania, Cozzi, Luca, Simonelli, Matteo, Bello, Lorenzo, Clerici, Elena, Riva, Marco, Santoro, Armando, Scorsetti, Marta
Format: info dataset
Terbitan: , 2019
Subjects:
Glioblastoma
Propensity score matching
Radiation therapy
Online Access: https://zenodo.org/record/3407389
ctrlnum 3407389
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Navarria, Pierina</creator><creator>Pessina, Federico</creator><creator>Franzese, Ciro</creator><creator>Tomatis, Stefano Maria</creator><creator>Perrino, Matteo Romualdo Anania</creator><creator>Cozzi, Luca</creator><creator>Simonelli, Matteo</creator><creator>Bello, Lorenzo</creator><creator>Clerici, Elena</creator><creator>Riva, Marco</creator><creator>Santoro, Armando</creator><creator>Scorsetti, Marta</creator><date>2019-09-13</date><description>This record contains raw data related to article "Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis" The current treatment for newly diagnosed glioblastoma consists of surgery followed by conventional radiotherapy (CRT) with concomitant and adjuvant chemotherapy. Hypofractionated radiation therapy (HFRT) has been investigated and it resulted feasible and safe. The aim of this study was to evaluate whether HFRT can be comparable to CRT. MATERIALS AND METHODS: The analysis included newly diagnosed glioblastoma patients treated with CRT 60&#x202F;Gy/30 fractions or HFRT 60&#x202F;Gy/15 fractions. A propensity score matching analysis (PSM) was performed using a logistic regression that considered age, KPS, extent of surgery, MGMT and IDH status. RESULTS: A total of 267 patients were included; before PSM 169 were in CRT-group and 98 in HRFT-group. After 1:1 matching, 82 patients resulted in each group. The median OS time was 17.9&#x202F;months for the CRT-group and 16.7&#x202F;months for the HFRT-group; the 1, 2, 3-year OS rates were 75.6%, 32.7%, and 15.5% for the CRT-group, and 75.6%, 33.3%, and 18.9% for the HFRT-group (p value&#x202F;=&#x202F;0.8). No statistically significant differences were recorded between the two radiation therapy treatments performed. CONCLUSIONS: A short course of radiation therapy would seem comparable to CRT in terms of outcome and less burdensome for these poor prognosis patients. </description><identifier>https://zenodo.org/record/3407389</identifier><identifier>10.5281/zenodo.3407389</identifier><identifier>oai:zenodo.org:3407389</identifier><relation>doi:10.1016/j.radonc.2017.12.006</relation><relation>pmid:29291951</relation><relation>doi:10.5281/zenodo.3407388</relation><relation>url:https://zenodo.org/communities/humanitasirccs</relation><rights>info:eu-repo/semantics/restrictedAccess</rights><subject>Glioblastoma</subject><subject>Propensity score matching</subject><subject>Radiation therapy</subject><title>Dataset related to article "Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis"</title><type>Other:info:eu-repo/semantics/other</type><type>Other:dataset</type><recordID>3407389</recordID></dc>
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Other:dataset
author Navarria, Pierina
Pessina, Federico
Franzese, Ciro
Tomatis, Stefano Maria
Perrino, Matteo Romualdo Anania
Cozzi, Luca
Simonelli, Matteo
Bello, Lorenzo
Clerici, Elena
Riva, Marco
Santoro, Armando
Scorsetti, Marta
title Dataset related to article "Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis"
publishDate 2019
topic Glioblastoma
Propensity score matching
Radiation therapy
url https://zenodo.org/record/3407389
contents This record contains raw data related to article "Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis" The current treatment for newly diagnosed glioblastoma consists of surgery followed by conventional radiotherapy (CRT) with concomitant and adjuvant chemotherapy. Hypofractionated radiation therapy (HFRT) has been investigated and it resulted feasible and safe. The aim of this study was to evaluate whether HFRT can be comparable to CRT. MATERIALS AND METHODS: The analysis included newly diagnosed glioblastoma patients treated with CRT 60 Gy/30 fractions or HFRT 60 Gy/15 fractions. A propensity score matching analysis (PSM) was performed using a logistic regression that considered age, KPS, extent of surgery, MGMT and IDH status. RESULTS: A total of 267 patients were included; before PSM 169 were in CRT-group and 98 in HRFT-group. After 1:1 matching, 82 patients resulted in each group. The median OS time was 17.9 months for the CRT-group and 16.7 months for the HFRT-group; the 1, 2, 3-year OS rates were 75.6%, 32.7%, and 15.5% for the CRT-group, and 75.6%, 33.3%, and 18.9% for the HFRT-group (p value = 0.8). No statistically significant differences were recorded between the two radiation therapy treatments performed. CONCLUSIONS: A short course of radiation therapy would seem comparable to CRT in terms of outcome and less burdensome for these poor prognosis patients.
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Lihat Juga