A RETROSPECTIVE STUDY ON THE THYROID DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE EFFECT OF DURATION OF DIABETES AND ANTI-GLYCEMIC MEDICATIONS ON MEAN HBA1C AND TSH LEVELS
| Main Author: | Dr. Zahoor Ahmed Khan, Dr. Nasrullah Zadran, Dr. Muhammad Mashood |
|---|---|
| Format: | Article |
| Terbitan: |
, 2020
|
| Online Access: |
https://zenodo.org/record/3968011 |
| ctrlnum |
3968011 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Dr. Zahoor Ahmed Khan, Dr. Nasrullah Zadran, Dr. Muhammad Mashood</creator><date>2020-07-31</date><description>Background: The relationship between type 2 diabetes and thyroid disorders is well established and requires testing a diabetic patient for the presence of thyroid abnormalities. Aim: to check the presence of hypothyroidism or hyperthyroidism in a sample of patients with type 2 diabetes and to check if anti-glycemic drugs have any effect on average levels of TSH and A1c.
Methods: This is a retrospective study of the documentation of 1,341 patients with type 2 diabetes at the Endocrinology and Diabetology department of Services Hospital Lahore for one-year duration from March 2019 to March 2020. The data was taken from patient registration software and analyzed for the presence of hypothyroidism or hyperthyroidism.
Results: Out of 1,341 patients with type 2 diabetes, 108 had thyroid dysfunction (8%), 7% had hypothyroidism, and 1% had hyperthyroidism. Mean TSH levels were significantly lower with diabetes duration> 5 years in patients with hypothyroidism (p = 0.032) and lower when metformin was introduced to treat hypothyroidism (p = 0.036). In patients with hyperthyroidism, this effect did not occur.
Conclusion: Thyroid disorders in patients with type 2 diabetes are underestimated in our country, mean TSH levels are lower in patients with hypothyroidism when metformin was used, and lower in patients with diabetes lasting more than 5 years.
Keywords: Type 2 diabetes, Hypothyroidism, Hyperthyroidism, Metformin.</description><identifier>https://zenodo.org/record/3968011</identifier><identifier>10.5281/zenodo.3968011</identifier><identifier>oai:zenodo.org:3968011</identifier><relation>doi:10.5281/zenodo.3968010</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/licenses/by/4.0/legalcode</rights><title>A RETROSPECTIVE STUDY ON THE THYROID DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE EFFECT OF DURATION OF DIABETES AND ANTI-GLYCEMIC MEDICATIONS ON MEAN HBA1C AND TSH LEVELS</title><type>Journal:Article</type><type>Journal:Article</type><recordID>3968011</recordID></dc>
|
| format |
Journal:Article Journal |
| author |
Dr. Zahoor Ahmed Khan, Dr. Nasrullah Zadran, Dr. Muhammad Mashood |
| title |
A RETROSPECTIVE STUDY ON THE THYROID DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE EFFECT OF DURATION OF DIABETES AND ANTI-GLYCEMIC MEDICATIONS ON MEAN HBA1C AND TSH LEVELS |
| publishDate |
2020 |
| url |
https://zenodo.org/record/3968011 |
| contents |
Background: The relationship between type 2 diabetes and thyroid disorders is well established and requires testing a diabetic patient for the presence of thyroid abnormalities. Aim: to check the presence of hypothyroidism or hyperthyroidism in a sample of patients with type 2 diabetes and to check if anti-glycemic drugs have any effect on average levels of TSH and A1c.
Methods: This is a retrospective study of the documentation of 1,341 patients with type 2 diabetes at the Endocrinology and Diabetology department of Services Hospital Lahore for one-year duration from March 2019 to March 2020. The data was taken from patient registration software and analyzed for the presence of hypothyroidism or hyperthyroidism.
Results: Out of 1,341 patients with type 2 diabetes, 108 had thyroid dysfunction (8%), 7% had hypothyroidism, and 1% had hyperthyroidism. Mean TSH levels were significantly lower with diabetes duration> 5 years in patients with hypothyroidism (p = 0.032) and lower when metformin was introduced to treat hypothyroidism (p = 0.036). In patients with hyperthyroidism, this effect did not occur.
Conclusion: Thyroid disorders in patients with type 2 diabetes are underestimated in our country, mean TSH levels are lower in patients with hypothyroidism when metformin was used, and lower in patients with diabetes lasting more than 5 years.
Keywords: Type 2 diabetes, Hypothyroidism, Hyperthyroidism, Metformin. |
| id |
IOS16997.3968011 |
| institution |
DEFAULT |
| institution_type |
library:public library |
| library |
DEFAULT |
| collection |
DEFAULT |
| city |
DEFAULT |
| province |
DEFAULT |
| repoId |
IOS16997 |
| first_indexed |
2022-06-06T06:33:21Z |
| last_indexed |
2022-06-06T06:33:21Z |
| recordtype |
dc |
| merged_child_boolean |
1 |
| _version_ |
1739397202240864256 |
| score |
17.60897 |