In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
Main Authors: | Dražić Branka, Antonijević-Nikolić Mirjana, Tanasković Slađana, Žižak Željko |
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Format: | Article Journal |
Bahasa: | eng |
Terbitan: |
, 2020
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Online Access: |
https://zenodo.org/record/4723363 |
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4723363 |
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fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Dražić Branka</creator><creator>Antonijević-Nikolić Mirjana</creator><creator>Tanasković Slađana</creator><creator>Žižak Željko</creator><date>2020-05-21</date><description>Two new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectroscopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelogenous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.</description><description>The authors
gratefully acknowledge Prof. Jelena Antić-Stanković (Faculty of Pharmacy, University of Belgrade, Serbia) for the antimicrobial test results and Prof. Katalin Mészáros Szécsényi (Faculty of Sciences, University of Novi Sad, Serbia) for useful suggestions.</description><identifier>https://zenodo.org/record/4723363</identifier><identifier>10.2298/JSC190710088D</identifier><identifier>oai:zenodo.org:4723363</identifier><language>eng</language><relation>info:eu-repo/grantAgreement/MESTD/Basic+Research+%28BR+or+ON%29/172014/</relation><relation>issn:0352-5139</relation><relation>gnd:gnd:1820-7421(Online)</relation><relation>url:https://www.shd.org.rs/JSCS/</relation><relation>url:https://zenodo.org/communities/iors</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/licenses/by/4.0/legalcode</rights><source>J Serb Chem Soc 85(5) 637-649</source><subject>Cu(II) and Co(II) complexes</subject><subject>octaazamacrocycle</subject><subject>antiproliferative activity</subject><subject>antimicrobial activity</subject><title>In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous</title><type>Journal:Article</type><type>Journal:Article</type><recordID>4723363</recordID></dc>
|
language |
eng |
format |
Journal:Article Journal Journal:Journal |
author |
Dražić Branka Antonijević-Nikolić Mirjana Tanasković Slađana Žižak Željko |
title |
In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous |
publishDate |
2020 |
topic |
Cu(II) and Co(II) complexes octaazamacrocycle antiproliferative activity antimicrobial activity |
url |
https://zenodo.org/record/4723363 |
contents |
Two new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectroscopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelogenous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans. The authors gratefully acknowledge Prof. Jelena Antić-Stanković (Faculty of Pharmacy, University of Belgrade, Serbia) for the antimicrobial test results and Prof. Katalin Mészáros Szécsényi (Faculty of Sciences, University of Novi Sad, Serbia) for useful suggestions. |
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ZAIN Publications |
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Cognizance Journal of Multidisciplinary Studies |
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Cognizance Journal of Multidisciplinary Studies |
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Stockholm |
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2022-06-06T04:34:25Z |
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