Data from: Male-benefit sexually antagonistic genotypes show elevated vulnerability to inbreeding
| Main Authors: | Grieshop, Karl, Berger, David, Arnqvist, Göran |
|---|---|
| Format: | info dataset Journal |
| Terbitan: |
, 2017
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/5012474 |
| ctrlnum |
5012474 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Grieshop, Karl</creator><creator>Berger, David</creator><creator>Arnqvist, Göran</creator><date>2017-06-05</date><description>Background: There is theoretical and empirical evidence for strong sexual selection in males having positive effects on population viability by serving to purify the genome of its mutation load at a low demographic cost. However, there is also theoretical and empirical evidence for negative effects of sexual selection on female fitness, and therefore population viability, known as the gender load. This can take the form of sexually antagonistic (SA) genetic variation where alleles with a selective advantage in males pose a detriment to female fitness, and vice versa. Here, using seed beetles, we shed light on a previously unexplored manifestation of the gender load: the effect of SA genetic variation on tolerance to inbreeding. Results: We found that genotypes encoding high male, but low female fitness exhibited significantly greater rates of extinction upon enforced inbreeding relative to genotypes encoding high female but low male fitness. Also, genotypes encoding low fitness in both sexes exhibited greater rates of extinction relative to generally high-fitness genotypes (though marginally non-significant), an expected finding attributable to variation in mutation load across genotypes. Despite follow-up investigations aiming to identify the mechanism(s) underlying these findings, it remains unclear whether the gender load and the mutation load have independent consequences for tolerance to inbreeding, or whether these two types of genetic architecture interact epistatically to render male-benefit genetic variation relatively intolerant to inbreeding. Conclusions: Regardless of the underlying mechanism(s), our results show that male-benefit/female-detriment SA genetic variation poses a previously unseen detriment to population viability due to its elevated vulnerability to inbreeding/homozygosity. This suggests that sexual selection in the context of SA genetic variance for fitness may enhance the gender load on population viability more than previously appreciated, due to selecting for male-benefit SA genetic variation that engenders lineages to extinction upon inbreeding. We note that our results imply that SA alleles that are sexually selected for in males may be underrepresented or even lacking in panels of inbred lines.</description><description>Grieshop et al. 2017_inbreedingMain data for inbreeding experiment, with mode of extinction data. Forecasting/calculating the probability of extinction after 10 generations based on first-generation extinction frequencies across isofemale lines can be done from these data (see Methods). Simulating the probability of extinction based on variation in female fecundity across isofemale lines (see Methods) will require raw female fecundity data for the "Lome" population at 29c from Berger et al. (2014). Please contact me if you need help acquiring these data, or following our methods.Grieshop et al. 2017_follow-upData for follow-up experiment, including estimates of male fertility (sex=m) and female fecundity (sex=f) across male-benefit (benefit.category=m) and female-benefit (benefit.category=f) categories (see Methods).</description><identifier>https://zenodo.org/record/5012474</identifier><identifier>10.5061/dryad.cv4h2</identifier><identifier>oai:zenodo.org:5012474</identifier><relation>doi:10.1186/s12862-017-0981-4</relation><relation>url:https://zenodo.org/communities/dryad</relation><rights>info:eu-repo/semantics/openAccess</rights><rights>https://creativecommons.org/publicdomain/zero/1.0/legalcode</rights><subject>intralocus sexual conflict</subject><subject>sexually antagonistic selection</subject><subject>mutation load</subject><subject>Balancing selection</subject><subject>Callosobruchus maculatus</subject><subject>Antagonistic pleiotropy</subject><title>Data from: Male-benefit sexually antagonistic genotypes show elevated vulnerability to inbreeding</title><type>Other:info:eu-repo/semantics/other</type><type>Other:dataset</type><recordID>5012474</recordID></dc>
|
| format |
Other:info:eu-repo/semantics/other Other Other:dataset Journal:Journal Journal |
| author |
Grieshop, Karl Berger, David Arnqvist, Göran |
| title |
Data from: Male-benefit sexually antagonistic genotypes show elevated vulnerability to inbreeding |
| publishDate |
2017 |
| topic |
intralocus sexual conflict sexually antagonistic selection mutation load Balancing selection Callosobruchus maculatus Antagonistic pleiotropy |
| url |
https://zenodo.org/record/5012474 |
| contents |
Background: There is theoretical and empirical evidence for strong sexual selection in males having positive effects on population viability by serving to purify the genome of its mutation load at a low demographic cost. However, there is also theoretical and empirical evidence for negative effects of sexual selection on female fitness, and therefore population viability, known as the gender load. This can take the form of sexually antagonistic (SA) genetic variation where alleles with a selective advantage in males pose a detriment to female fitness, and vice versa. Here, using seed beetles, we shed light on a previously unexplored manifestation of the gender load: the effect of SA genetic variation on tolerance to inbreeding. Results: We found that genotypes encoding high male, but low female fitness exhibited significantly greater rates of extinction upon enforced inbreeding relative to genotypes encoding high female but low male fitness. Also, genotypes encoding low fitness in both sexes exhibited greater rates of extinction relative to generally high-fitness genotypes (though marginally non-significant), an expected finding attributable to variation in mutation load across genotypes. Despite follow-up investigations aiming to identify the mechanism(s) underlying these findings, it remains unclear whether the gender load and the mutation load have independent consequences for tolerance to inbreeding, or whether these two types of genetic architecture interact epistatically to render male-benefit genetic variation relatively intolerant to inbreeding. Conclusions: Regardless of the underlying mechanism(s), our results show that male-benefit/female-detriment SA genetic variation poses a previously unseen detriment to population viability due to its elevated vulnerability to inbreeding/homozygosity. This suggests that sexual selection in the context of SA genetic variance for fitness may enhance the gender load on population viability more than previously appreciated, due to selecting for male-benefit SA genetic variation that engenders lineages to extinction upon inbreeding. We note that our results imply that SA alleles that are sexually selected for in males may be underrepresented or even lacking in panels of inbred lines. Grieshop et al. 2017_inbreedingMain data for inbreeding experiment, with mode of extinction data. Forecasting/calculating the probability of extinction after 10 generations based on first-generation extinction frequencies across isofemale lines can be done from these data (see Methods). Simulating the probability of extinction based on variation in female fecundity across isofemale lines (see Methods) will require raw female fecundity data for the "Lome" population at 29c from Berger et al. (2014). Please contact me if you need help acquiring these data, or following our methods.Grieshop et al. 2017_follow-upData for follow-up experiment, including estimates of male fertility (sex=m) and female fecundity (sex=f) across male-benefit (benefit.category=m) and female-benefit (benefit.category=f) categories (see Methods). |
| id |
IOS16997.5012474 |
| institution |
ZAIN Publications |
| institution_id |
7213 |
| institution_type |
library:special library |
| library |
Cognizance Journal of Multidisciplinary Studies |
| library_id |
5267 |
| collection |
Cognizance Journal of Multidisciplinary Studies |
| repository_id |
16997 |
| subject_area |
Multidisciplinary |
| city |
Stockholm |
| province |
INTERNASIONAL |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS16997 |
| first_indexed |
2022-06-06T05:27:33Z |
| last_indexed |
2022-06-06T05:27:33Z |
| recordtype |
dc |
| _version_ |
1734905300234797056 |
| score |
17.608967 |