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Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

Main Authors: Blondiaux, Nicolas, Moune, Martin, Desroses, Matthieu, Frita, Rosangela, Flipo, Marion, Mathys, Vanessa, Soetaert, Karine, Kiass, Mehdi, Delorme, Vincent, Djaout, Kamel, Trebosc, Vincent, Kemmer, Christian, Wintjens, René, Wohlkönig, Alexandre, Antoine, Rudy, Huot, Ludovic, Hot, David, Coscolla, Mireia, Feldmann, Julia, Gagneux, Sebastien, Locht, Camille, Brodin, Priscille, Gitzinger, Marc, Deprez, Benoit, Willand, Nicolas, Baulard, Alain R.
Format: info dataset Journal
Terbitan: , 2018
Subjects:
drug discovery
Mycobacterium tuberculosis
Tuberculosis
Online Access: https://zenodo.org/record/5021631
ctrlnum 5021631
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format Other:info:eu-repo/semantics/other
Other
Other:dataset
Journal:Journal
Journal
author Blondiaux, Nicolas
Moune, Martin
Desroses, Matthieu
Frita, Rosangela
Flipo, Marion
Mathys, Vanessa
Soetaert, Karine
Kiass, Mehdi
Delorme, Vincent
Djaout, Kamel
Trebosc, Vincent
Kemmer, Christian
Wintjens, René
Wohlkönig, Alexandre
Antoine, Rudy
Huot, Ludovic
Hot, David
Coscolla, Mireia
Feldmann, Julia
Gagneux, Sebastien
Locht, Camille
Brodin, Priscille
Gitzinger, Marc
Deprez, Benoit
Willand, Nicolas
Baulard, Alain R.
title Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
publishDate 2018
topic drug discovery
Mycobacterium tuberculosis
Tuberculosis
url https://zenodo.org/record/5021631
contents Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide.
BCG_DMSO.fastqPart 1 of Databases S1 (transcriptomic data) BCG_DMSO.fastqBCG_BDM41906.fastqPart 2 of Databases S1 (transcriptomic data) BCG_BDM41906.fastqBCG_SMARt-420.fastqPart 3 of Databases S1 (transcriptomic data) BCG_SMARt-420.fastq
id IOS16997.5021631
institution ZAIN Publications
institution_id 7213
institution_type library:special
library
library Cognizance Journal of Multidisciplinary Studies
library_id 5267
collection Cognizance Journal of Multidisciplinary Studies
repository_id 16997
subject_area Multidisciplinary
city Stockholm
province INTERNASIONAL
shared_to_ipusnas_str 1
repoId IOS16997
first_indexed 2022-06-06T05:23:47Z
last_indexed 2022-06-06T05:23:47Z
recordtype dc
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