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Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"

Main Authors: Navarria, Pierina, Pessina, Federico, Cozzi, Luca, Tomatis, Stefano Maria, Reggiori, Giacomo, Simonelli, Matteo, Santoro, Armando, Clerici, Elena, Franzese, Ciro, Carta, Giulio Alberto, Conti Nibali, M, Bello, Lorenzo, Scorsetti, Marta
Format: info dataset eJournal
Terbitan: , 2019
Subjects:
Elderly
adjuvant chemotherapy
glioblastoma
hypofractionated radiotherapy
Online Access: https://zenodo.org/record/3517906
ctrlnum 3517906
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Navarria, Pierina</creator><creator>Pessina, Federico</creator><creator>Cozzi, Luca</creator><creator>Tomatis, Stefano Maria</creator><creator>Reggiori, Giacomo</creator><creator>Simonelli, Matteo</creator><creator>Santoro, Armando</creator><creator>Clerici, Elena</creator><creator>Franzese, Ciro</creator><creator>Carta, Giulio Alberto</creator><creator>Conti Nibali, M</creator><creator>Bello, Lorenzo</creator><creator>Scorsetti, Marta</creator><date>2019-09-13</date><description>This record contains raw data related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis" OBJECTIVE:: To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity. METHODS:: Patients with newly diagnosed glioblastoma, age &#x2A7E;70 years, Karnofsky performance scale (KPS) score &#x2A7D;60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70.88 Gy. RESULTS:: Thirty patients were treated, with a median age of 75 years. Concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT) was administered in 7 (23.3%) and 11 (40.7%) patients received only adjuvant TMZ-CHT. The median, 6-month PFS, and 12-month PFS were 5.0 months, 43.3%, and 20%, respectively. The median, 6-month OS, and 12-month OS were 8 months, 90%, and 30%, respectively. At the last observation time, 26 patients (86.7%) were dead and 4 (13.3%) were alive. No increase in steroid drugs was required during radiotherapy treatment and a reduction was possible in 12 (40%). Patients with KPS=60, RPA V, MGMT methylated status, neurological status stable or improved after surgery and who underwent HFRT with concurrent and adjuvant CHT, had the better outcome. CONCLUSION:: HFRT has proven to be feasible and effective, with limited morbidity, for selected elderly and frail patients with newly diagnosed glioblastoma. The primary objective of this study was not reached in the whole cohort but only in selected patients, who need more aggressive treatment.</description><identifier>https://zenodo.org/record/3517906</identifier><identifier>10.5281/zenodo.3517906</identifier><identifier>oai:zenodo.org:3517906</identifier><relation>doi:10.1177/0300891618792483</relation><relation>pmid:30131010</relation><relation>doi:10.5281/zenodo.3407394</relation><relation>url:https://zenodo.org/communities/humanitasirccs</relation><rights>info:eu-repo/semantics/restrictedAccess</rights><subject>Elderly</subject><subject>adjuvant chemotherapy</subject><subject>glioblastoma</subject><subject>hypofractionated radiotherapy</subject><title>Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"</title><type>Other:info:eu-repo/semantics/other</type><type>Other:dataset</type><recordID>3517906</recordID></dc>
format Other:info:eu-repo/semantics/other
Other
Other:dataset
Journal:eJournal
Journal
author Navarria, Pierina
Pessina, Federico
Cozzi, Luca
Tomatis, Stefano Maria
Reggiori, Giacomo
Simonelli, Matteo
Santoro, Armando
Clerici, Elena
Franzese, Ciro
Carta, Giulio Alberto
Conti Nibali, M
Bello, Lorenzo
Scorsetti, Marta
title Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"
publishDate 2019
topic Elderly
adjuvant chemotherapy
glioblastoma
hypofractionated radiotherapy
url https://zenodo.org/record/3517906
contents This record contains raw data related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis" OBJECTIVE:: To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity. METHODS:: Patients with newly diagnosed glioblastoma, age ⩾70 years, Karnofsky performance scale (KPS) score ⩽60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70.88 Gy. RESULTS:: Thirty patients were treated, with a median age of 75 years. Concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT) was administered in 7 (23.3%) and 11 (40.7%) patients received only adjuvant TMZ-CHT. The median, 6-month PFS, and 12-month PFS were 5.0 months, 43.3%, and 20%, respectively. The median, 6-month OS, and 12-month OS were 8 months, 90%, and 30%, respectively. At the last observation time, 26 patients (86.7%) were dead and 4 (13.3%) were alive. No increase in steroid drugs was required during radiotherapy treatment and a reduction was possible in 12 (40%). Patients with KPS=60, RPA V, MGMT methylated status, neurological status stable or improved after surgery and who underwent HFRT with concurrent and adjuvant CHT, had the better outcome. CONCLUSION:: HFRT has proven to be feasible and effective, with limited morbidity, for selected elderly and frail patients with newly diagnosed glioblastoma. The primary objective of this study was not reached in the whole cohort but only in selected patients, who need more aggressive treatment.
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institution Universitas PGRI Palembang
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collection Marga Life in South Sumatra in the Past: Puyang Concept Sacrificed and Demythosized
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first_indexed 2022-07-26T01:32:44Z
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