Pengaruh Pemberian Ekstrak Biji Klabet (Trigonella foenum-graecum L.) Terhadap Kadar Hormon Estradiol Dan FSH Plasma Tikus Putih Betina Galur Wistar Prepubertal
| Main Authors: | Agustini, Kurnia, Wiryowidagdo, Sumali, Kusmana, Dadang |
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| Format: | Book application/pdf Journal |
| Terbitan: |
UI Scholars Hub
, 2005
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| Subjects: | |
| Online Access: |
https://scholarhub.ui.ac.id/mik/vol2/iss2/3 https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1022&context=mik |
Daftar Isi:
- Biji Klabet or Fenugreek (Trigonella foenum-graecum L.) contains steroidal sapogenins such as diosgenin, tigogenin, gitogenin, yamogenin and trigoneoside, that are suspected having an estrogen-like effect or as phytoestrogen. The objective of this study was to evaluate the estrogen-like effect of biji klabet alcohol extracts. This research used immature Wistar female rats, age of 19 days, which were represent the climacteric/menopause phase. The testing animals were divided into five groups, namely normal group, estradiol control group and three level dose groups of fenugreek extract (30 mg/200 gBW; 60 mg/200 gBW and 120 mg/200 gBW). The result showed that on 120 mg/200 gBW fenugreek extract significantly (a=0.05) increased estradiol and FSH level on immature rat. Analysis of vaginal smear showed vaginal lubrication effect, surprisingly on 120 mg/200 gBW could induce estrous cycle.