Uji efek analgesik ekstrak etanol 70% bunga mawar (Rosa chinensis Jacq.) pada mencit yang diinduksi asam asetat = The analgesic effect testing of ethanol extract 70% of rose (Rosa chinensis Jacq.) on acetic acid-induced in mice
| Main Author: | Riza Marlyne, author |
|---|---|
| Format: | Bachelors |
| Terbitan: |
Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia
, 2012
|
| Subjects: | |
| Online Access: |
http://lib.ui.ac.id/file?file=digital/20311589-S42961-Uji efek.pdf |
| ctrlnum |
20311589 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>Uji efek analgesik ekstrak etanol 70% bunga mawar (Rosa chinensis Jacq.) pada mencit yang diinduksi asam asetat = The analgesic effect testing of ethanol extract 70% of rose (Rosa chinensis Jacq.) on acetic acid-induced in mice</title><creator>Riza Marlyne, author</creator><type>Thesis:Bachelors</type><place/><publisher>Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia</publisher><date>2012</date><description>[<b>ABSTRAK</b><br>Pada penelitian terdahulu diketahui bahwa tanaman Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida, memiliki efek analgesik. Tujuan
penelitian ini adalah untuk menguji efek analgesik ekstrak etanol 70% bunga
mawar (Rosa chinensis Jacq.). Dalam penelitian ini digunakan metode Sigmund
(metode geliat) pada 25 ekor mencit jantan yang telah lulus uji kepekaan, dibagi
dalam 5 kelompok, yaitu kelompok I sebagai kontrol negatif diberikan CMC 0,5%,
kelompok II sebagai kontrol positif diberikan asetosal, kelompok III, IV dan V
diberikan ekstrak bunga mawar berturut-turut sebesar 0,005; 0,01 dan 0,02 g/20 g
BB mencit,. Masing-masing kelompok diberikan bahan uji secara oral, satu jam
kemudian diinduksi dengan asam asetat 0,6% secara intraperitoneal, setelah
sepuluh menit diamati dan dihitung jumlah geliat dengan interval lima menit
selama satu jam. Hasil penelitian menunjukkan bahwa, dosis I (0,005 g/20 g BB
mencit) dan dosis II (0,01 g/20 g BB mencit) memberikan persentase proteksi
berturut-turut (89,12% dan 73,69%) dan persentase efektivitas yang tinggi
(98,15% dan 81,16%), dan hampir setara dengan kontrol positif yaitu asetosal
dengan dosis 13 mg/20 g BB mencit yang memberikan persentase proteksi
90,80% dan persentase efektivitas 100%.
<hr>
<b>ABSTRACT</b><br>
In the previous study the analgesic effect of some rose (Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida) was investigated. The aim of this
study was to investigate analgesic effect of the ethanol extract 70% of Rose (Rosa
chinensis Jacq.). This study used Sigmund method (writhing method) at 25 male
mice which have passed sensitivity test, divided into five groupes. Group I as
negative control was administered 0,5% CMC, group II as positive control was
administered acetosal, group III, IV and V was administered extract of rose at
0,005; 0,01 and 0,02 g/20 g BW. One hour before intraperitonial injection of
acetic acid 0,6%, drugs were orally administered to mice. The number of
writhings exhibited by each animal was counted for one hour with interval five
minute beginning ten minute after acetic acid induction. The result shows that
effectiveness at dose I (0,005 g/20 g BW) and dose II (0,01 g/20 g BW) had
percent protection (89,12% and 73,69%) and higher percent effectiveness
(98,15% and 81,16%), and almost equal with positif control, acetosal dose 13
mg/20 g BW with percent protection 90,80% and percent effectiveness 100%., In the previous study the analgesic effect of some rose (Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida) was investigated. The aim of this
study was to investigate analgesic effect of the ethanol extract 70% of Rose (Rosa
chinensis Jacq.). This study used Sigmund method (writhing method) at 25 male
mice which have passed sensitivity test, divided into five groupes. Group I as
negative control was administered 0,5% CMC, group II as positive control was
administered acetosal, group III, IV and V was administered extract of rose at
0,005; 0,01 and 0,02 g/20 g BW. One hour before intraperitonial injection of
acetic acid 0,6%, drugs were orally administered to mice. The number of
writhings exhibited by each animal was counted for one hour with interval five
minute beginning ten minute after acetic acid induction. The result shows that
effectiveness at dose I (0,005 g/20 g BW) and dose II (0,01 g/20 g BW) had
percent protection (89,12% and 73,69%) and higher percent effectiveness
(98,15% and 81,16%), and almost equal with positif control, acetosal dose 13
mg/20 g BW with percent protection 90,80% and percent effectiveness 100%.]</description><subject>Analgesics</subject><identifier>20311589</identifier><source>http://lib.ui.ac.id/file?file=digital/20311589-S42961-Uji efek.pdf</source><recordID>20311589</recordID></dc>
|
| format |
Thesis:Bachelors Thesis |
| author |
Riza Marlyne, author |
| title |
Uji efek analgesik ekstrak etanol 70% bunga mawar (Rosa chinensis Jacq.) pada mencit yang diinduksi asam asetat = The analgesic effect testing of ethanol extract 70% of rose (Rosa chinensis Jacq.) on acetic acid-induced in mice |
| publisher |
Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia |
| publishDate |
2012 |
| topic |
Analgesics |
| url |
http://lib.ui.ac.id/file?file=digital/20311589-S42961-Uji efek.pdf |
| contents |
[<b>ABSTRAK</b><br>Pada penelitian terdahulu diketahui bahwa tanaman Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida, memiliki efek analgesik. Tujuan
penelitian ini adalah untuk menguji efek analgesik ekstrak etanol 70% bunga
mawar (Rosa chinensis Jacq.). Dalam penelitian ini digunakan metode Sigmund
(metode geliat) pada 25 ekor mencit jantan yang telah lulus uji kepekaan, dibagi
dalam 5 kelompok, yaitu kelompok I sebagai kontrol negatif diberikan CMC 0,5%,
kelompok II sebagai kontrol positif diberikan asetosal, kelompok III, IV dan V
diberikan ekstrak bunga mawar berturut-turut sebesar 0,005; 0,01 dan 0,02 g/20 g
BB mencit,. Masing-masing kelompok diberikan bahan uji secara oral, satu jam
kemudian diinduksi dengan asam asetat 0,6% secara intraperitoneal, setelah
sepuluh menit diamati dan dihitung jumlah geliat dengan interval lima menit
selama satu jam. Hasil penelitian menunjukkan bahwa, dosis I (0,005 g/20 g BB
mencit) dan dosis II (0,01 g/20 g BB mencit) memberikan persentase proteksi
berturut-turut (89,12% dan 73,69%) dan persentase efektivitas yang tinggi
(98,15% dan 81,16%), dan hampir setara dengan kontrol positif yaitu asetosal
dengan dosis 13 mg/20 g BB mencit yang memberikan persentase proteksi
90,80% dan persentase efektivitas 100%.
<hr>
<b>ABSTRACT</b><br>
In the previous study the analgesic effect of some rose (Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida) was investigated. The aim of this
study was to investigate analgesic effect of the ethanol extract 70% of Rose (Rosa
chinensis Jacq.). This study used Sigmund method (writhing method) at 25 male
mice which have passed sensitivity test, divided into five groupes. Group I as
negative control was administered 0,5% CMC, group II as positive control was
administered acetosal, group III, IV and V was administered extract of rose at
0,005; 0,01 and 0,02 g/20 g BW. One hour before intraperitonial injection of
acetic acid 0,6%, drugs were orally administered to mice. The number of
writhings exhibited by each animal was counted for one hour with interval five
minute beginning ten minute after acetic acid induction. The result shows that
effectiveness at dose I (0,005 g/20 g BW) and dose II (0,01 g/20 g BW) had
percent protection (89,12% and 73,69%) and higher percent effectiveness
(98,15% and 81,16%), and almost equal with positif control, acetosal dose 13
mg/20 g BW with percent protection 90,80% and percent effectiveness 100%., In the previous study the analgesic effect of some rose (Rosa damascena,
Rosa multiflora, Rosa canina, Rosa hybrida) was investigated. The aim of this
study was to investigate analgesic effect of the ethanol extract 70% of Rose (Rosa
chinensis Jacq.). This study used Sigmund method (writhing method) at 25 male
mice which have passed sensitivity test, divided into five groupes. Group I as
negative control was administered 0,5% CMC, group II as positive control was
administered acetosal, group III, IV and V was administered extract of rose at
0,005; 0,01 and 0,02 g/20 g BW. One hour before intraperitonial injection of
acetic acid 0,6%, drugs were orally administered to mice. The number of
writhings exhibited by each animal was counted for one hour with interval five
minute beginning ten minute after acetic acid induction. The result shows that
effectiveness at dose I (0,005 g/20 g BW) and dose II (0,01 g/20 g BW) had
percent protection (89,12% and 73,69%) and higher percent effectiveness
(98,15% and 81,16%), and almost equal with positif control, acetosal dose 13
mg/20 g BW with percent protection 90,80% and percent effectiveness 100%.] |
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