Perbandingan kadar Prostaglandin E2 (PGE2) dalam cairan Krevikular Gingiva Anterior Mandibula pasien pada tahap awal perawatan Ortodonti menggunakan braket Self-Ligating pasif dengan braket konvensional Preadjusted MBT = Comparison of Prostaglandin E2 level Gingiva Crevicular Fluid of human anterior mandible during initial alignment between passive Self-Ligating and Conventional Systems
| Main Authors: | Poetrie Febrinadya, author, Add author: Benny M. Soegiharto, supervisor, Add author: Nurtami Soedarsono, supervisor, Add author: Krisnawati, supervisor, Add author: Miesje Karmiati Purwanegara, examiner, Add author: Retno Widayati, examiner |
|---|---|
| Format: | Masters Bachelors |
| Terbitan: |
, 2012
|
| Subjects: | |
| Online Access: |
https://lib.ui.ac.id/detail?id=20314413 |
| ctrlnum |
20314413 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><type>Thesis:Masters</type><title>Perbandingan kadar Prostaglandin E2 (PGE2) dalam cairan Krevikular Gingiva Anterior Mandibula pasien pada tahap awal perawatan Ortodonti menggunakan braket Self-Ligating pasif dengan braket konvensional Preadjusted MBT = Comparison of Prostaglandin E2 level Gingiva Crevicular Fluid of human anterior mandible during initial alignment between passive Self-Ligating and Conventional Systems</title><creator>Poetrie Febrinadya, author</creator><creator>Add author: Benny M. Soegiharto, supervisor</creator><creator>Add author: Nurtami Soedarsono, supervisor</creator><creator>Add author: Krisnawati, supervisor</creator><creator>Add author: Miesje Karmiati Purwanegara, examiner</creator><creator>Add author: Retno Widayati, examiner</creator><publisher/><date>2012</date><subject>Prostaglandins.</subject><description>[<b>ABSTRAK</b><br>
Pendahuluan: Pergerakan gigi ortodonti akan merangsang terjadinya proses
inflamasi sehingga mengeluarkan mediator inflamasi. Prostaglandin E2 (PGE2)
adalah salah satu mediator inflamasi yang dikeluarkan selama pergerakan
ortodonti dan berperan dalam resorpsi tulang. Proses inflamasi ini terjadi pada
semua pergerakan ortodonti termasuk pada penggunaan sistem self-ligating.
Walaupun sistem self-ligating diklaim banyak memiliki keuntungan, termasuk
efeknya pada ligamen periodontal, akan tetapi belum ada penelitian secara
biomolekular yang membandingkan mediator inflamasi dalam ligamen
periodontal.
<br><br>
Metode: Duabelas pasien dari klinik ortodonti, FKG-UI, dengan kasus
nonekstraksi dan indeks iregularitas pada insisif mandibula sebesar 4-9 mm,
mendapatkan perawatan ortodonti dengan sistem self-ligating pasif (Damon Q,
Ormco) dan sistem konvensional preskripsi MBT (Agile, 3M). Cairan krevikular
gingiva diambil dari sisi labial regio insisif mandibula pada 0 jam (sebagai
kontrol), 24 jam, dan 4 minggu. Kadar PGE2 diperiksa menggunakan ELISA
<br><br>
Hasil: Walaupun secara statistik tidak terdapat perbedaan kadar PGE2 pada
pemakaian braket self-ligating dibandingkan dengan konvensional pada 0 jam, 24
jam (p=0,815), dan 4 minggu (p=0,534), namun secara deskriptif kelompok selfligating
memiliki kadar PGE2 lebih tinggi dari konvensional secara konsisten pada
0, 24jam, dan 4 minggu. Pada waktu 24 jam, kadar PGE2 meningkat dibandingkan
saat 0 jam, pada kedua sistem, dan kadar PGE2 pada kelompok self-ligating pasif
(302,55±26,33 pg/ mL) lebih besar daripada kelompok konvensional
(264,43±83,08 pg/mL). Pada waktu 4 minggu, kadar PGE2 menurun dibandingkan
dengan waktu pengambilan 0 jam dan 24 jam, pada kedua kelompok sistem, dan
kadar PGE2 pada kelompok self-ligating (236,17±42,63 pg/mL) lebih besar dari
kelompok konvensional (208,267±81,83 pg/mL).
Kesimpulan: Penelitian kami menyimpulkan bahwa sistem self-ligating
memberikan respon selular yang berbeda dibandingkan sistem konvensional.;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement, Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement]</description><identifier>https://lib.ui.ac.id/detail?id=20314413</identifier><recordID>20314413</recordID></dc>
|
| format |
Thesis:Masters Thesis Thesis:Bachelors |
| author |
Poetrie Febrinadya, author Add author: Benny M. Soegiharto, supervisor Add author: Nurtami Soedarsono, supervisor Add author: Krisnawati, supervisor Add author: Miesje Karmiati Purwanegara, examiner Add author: Retno Widayati, examiner |
| title |
Perbandingan kadar Prostaglandin E2 (PGE2) dalam cairan Krevikular Gingiva Anterior Mandibula pasien pada tahap awal perawatan Ortodonti menggunakan braket Self-Ligating pasif dengan braket konvensional Preadjusted MBT = Comparison of Prostaglandin E2 level Gingiva Crevicular Fluid of human anterior mandible during initial alignment between passive Self-Ligating and Conventional Systems |
| publishDate |
2012 |
| topic |
Prostaglandins |
| url |
https://lib.ui.ac.id/detail?id=20314413 |
| contents |
[<b>ABSTRAK</b><br>
Pendahuluan: Pergerakan gigi ortodonti akan merangsang terjadinya proses
inflamasi sehingga mengeluarkan mediator inflamasi. Prostaglandin E2 (PGE2)
adalah salah satu mediator inflamasi yang dikeluarkan selama pergerakan
ortodonti dan berperan dalam resorpsi tulang. Proses inflamasi ini terjadi pada
semua pergerakan ortodonti termasuk pada penggunaan sistem self-ligating.
Walaupun sistem self-ligating diklaim banyak memiliki keuntungan, termasuk
efeknya pada ligamen periodontal, akan tetapi belum ada penelitian secara
biomolekular yang membandingkan mediator inflamasi dalam ligamen
periodontal.
<br><br>
Metode: Duabelas pasien dari klinik ortodonti, FKG-UI, dengan kasus
nonekstraksi dan indeks iregularitas pada insisif mandibula sebesar 4-9 mm,
mendapatkan perawatan ortodonti dengan sistem self-ligating pasif (Damon Q,
Ormco) dan sistem konvensional preskripsi MBT (Agile, 3M). Cairan krevikular
gingiva diambil dari sisi labial regio insisif mandibula pada 0 jam (sebagai
kontrol), 24 jam, dan 4 minggu. Kadar PGE2 diperiksa menggunakan ELISA
<br><br>
Hasil: Walaupun secara statistik tidak terdapat perbedaan kadar PGE2 pada
pemakaian braket self-ligating dibandingkan dengan konvensional pada 0 jam, 24
jam (p=0,815), dan 4 minggu (p=0,534), namun secara deskriptif kelompok selfligating
memiliki kadar PGE2 lebih tinggi dari konvensional secara konsisten pada
0, 24jam, dan 4 minggu. Pada waktu 24 jam, kadar PGE2 meningkat dibandingkan
saat 0 jam, pada kedua sistem, dan kadar PGE2 pada kelompok self-ligating pasif
(302,55±26,33 pg/ mL) lebih besar daripada kelompok konvensional
(264,43±83,08 pg/mL). Pada waktu 4 minggu, kadar PGE2 menurun dibandingkan
dengan waktu pengambilan 0 jam dan 24 jam, pada kedua kelompok sistem, dan
kadar PGE2 pada kelompok self-ligating (236,17±42,63 pg/mL) lebih besar dari
kelompok konvensional (208,267±81,83 pg/mL).
Kesimpulan: Penelitian kami menyimpulkan bahwa sistem self-ligating
memberikan respon selular yang berbeda dibandingkan sistem konvensional.;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement;Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement, Introduction: Inflammation process, as a result of orthodontic tooth movement,
will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one
of the inflammatory mediator that is released during the orthodontic movement
and plays an important role in bone resorption. These inflammatory process
occurred in all orthodontic movement included in orthodontic treatment using
self-ligating system. Although self-ligating system?s advantages have been
claimed, including the effect of the system in periodontal ligament, there are still
no research in biomolecular level comparing the mediator release in periodontal
ligament.
<br><br>
Objective: The purpose of this study was to examine PGE2 concentration in
gingival crevicular fluid (GCF) during initial alignment of anterior mandible,
using two different system brackets, passive self-ligating and conventional
bracket.
<br><br>
Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and
prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry,
Universitas Indonesia, were having orthodontic treatment. They were divided into
2 groups, each group were using Damon passive self-ligating system (Damon Q,
Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M).
GCF were taken from labial site of mandibular incisors at 0 hour (served as
control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit.
<br><br>
Results: There was no statistically difference in PGE2 level in self-ligating system
group compared with conventional group, at 0, 24 hours, and 4 weeks, but from
descriptive view self-ligating group had higher PGE2 levels than conventional at
0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0
hour, in both groups, and mean of PGE2 level was higher in self-ligating group
(302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4
weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and
mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL)
than conventional group (208,267±81,83 pg/mL).
Conclusion: Our findings suggest that self-ligating giving difference cellular
response than conventional systems during orthodontic tooth movement] |
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