Korelasi ketebalan adiposa epikardial dengan derajat stenosis arteri koroner pada pasien penyakit jantung koroner stabil = Correlation of epicardial adipose thickness with the severity of coronary artery stenosis in stable coronary heart disease patient
| Main Author: | Robert Noldy Ngantung, author |
|---|---|
| Format: | Masters Bachelors |
| Terbitan: |
, 2014
|
| Subjects: | |
| Online Access: |
http://lib.ui.ac.id/file?file=digital/2015-11/20389748-T-Robert Noldy Ngantung.pdf |
| ctrlnum |
20389748 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>Korelasi ketebalan adiposa epikardial dengan derajat stenosis arteri koroner pada pasien penyakit jantung koroner stabil = Correlation of epicardial adipose thickness with the severity of coronary artery stenosis in stable coronary heart disease patient</title><creator>Robert Noldy Ngantung, author</creator><type>Thesis:Masters</type><place/><publisher/><date>2014</date><description>[<b>ABSTRAK</b><br>
Latar Belakang
Jaringan adiposa epikardial (JAE) sebagai jaringan adiposa visera penting peranannya
dalam proses aterosklerosis di arteri koroner. Studi sebelumnya menunjukkan ketebalan
adiposa epikardial lebih besar pada pasien dengan penyakit jantung koroner (PJK)
Tujuan
Mengetahui korelasi antara ketebalan adiposa epikardial dengan derajat stenosis arteri
koroner pada pasien PJK stabil
Metode
Dilakukan studi potong lintang pada tujuh puluh pasien PJK stabil yang menjalani
angiografi koroner. Derajat stenosis arteri koroner dinilai dengan skor Gensini > 40
(berat) dan &#8804; 40 (ringan-sedang). Ketebalan adiposa epikardial dinilai dengan
ekokardiografi transtorakal pada fase sistolik akhir tampilan parasternal long axis.
Hasil
Nilai rerata ketebalan adiposa epikardial adalah 5,96 mm (SB 1,76) dan nilai median
skor Gensini adalah 35,0 (kisaran 2-126). Analisis bivariat menunjukkan korelasi positif
kuat yang bermakna (r = 0,768, p < 0,001). Nilai titik potong terbaik dari ketebalan
adiposa epikardial yang memiliki nilai klinis berkaitan dengan derajat stenosis arteri
koroner berdasarkan skor Gensini adalah 6,15 mm dengan sensitivitas 85,29%,
spesifisitas 83,33%, nilai duga positif 82%, nilai duga negatif 85% dengan AUC sebesar
0,893 (IK 95% 0,814-0,971, p < 0,001).
Simpulan
Ketebalan adiposa epikardial berkorelasi signifikan dengan derajat stenosis arteri
koroner berdasarkan skor Gensini. Ketebalan adiposa epikardial 6,15 mm memiliki
kemampuan yang cukup baik untuk membedakan pasien PJK stabil ringan-sedang dan
berat berdasarkan skor gensini.
<hr>
<b>ABSTRACT</b><br>
Background:
Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role in
the atherosclerotic cardiovascular disease. Previous studies have shown that EAT is
thicker in those with coronary heart disease.
Objective:
To determine the correlation of epicardial adipose thickness with the severity of
coronary artery stenosis in stable coronary heart disease (CHD) patient
Method:
A cross-sectional study was conducted on seventy stable CHD patient undergoing
coronary angiography. Severity of coronary artery stenosis was evaluated using Gensini
scoring system : > 40 (severe) and &#8804; 40 (mild-moderate). Epicardial adipose tissue was
measured using transthoracic echocardiography at end-systole from parasternal longaxis
view.
Results :
Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median value
of Gensini score was 35,0 (range 2-126). The correlation test showed a significant
strong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardial
adipose thickness which has a clinical value correlating to severity of coronary artery
stenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,
specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % and
AUC of 0,893 (CI 0,814-0,971, p < 0,001)
Conclusion :
Epicardial fat thickness is significantly correlated to the severity of coronary artery
stenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has a
good capability in discriminating mild-moderate dan severe stable CHD patient based
on Gensini scoring system, Background:
Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role in
the atherosclerotic cardiovascular disease. Previous studies have shown that EAT is
thicker in those with coronary heart disease.
Objective:
To determine the correlation of epicardial adipose thickness with the severity of
coronary artery stenosis in stable coronary heart disease (CHD) patient
Method:
A cross-sectional study was conducted on seventy stable CHD patient undergoing
coronary angiography. Severity of coronary artery stenosis was evaluated using Gensini
scoring system : > 40 (severe) and &#8804; 40 (mild-moderate). Epicardial adipose tissue was
measured using transthoracic echocardiography at end-systole from parasternal longaxis
view.
Results :
Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median value
of Gensini score was 35,0 (range 2-126). The correlation test showed a significant
strong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardial
adipose thickness which has a clinical value correlating to severity of coronary artery
stenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,
specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % and
AUC of 0,893 (CI 0,814-0,971, p < 0,001)
Conclusion :
Epicardial fat thickness is significantly correlated to the severity of coronary artery
stenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has a
good capability in discriminating mild-moderate dan severe stable CHD patient based
on Gensini scoring system]</description><subject>Heart Disease.</subject><subject>Echocardiography.</subject><identifier>20389748</identifier><source>http://lib.ui.ac.id/file?file=digital/2015-11/20389748-T-Robert Noldy Ngantung.pdf</source><recordID>20389748</recordID></dc>
|
| format |
Thesis:Masters Thesis Thesis:Bachelors |
| author |
Robert Noldy Ngantung, author |
| title |
Korelasi ketebalan adiposa epikardial dengan derajat stenosis arteri koroner pada pasien penyakit jantung koroner stabil = Correlation of epicardial adipose thickness with the severity of coronary artery stenosis in stable coronary heart disease patient |
| publishDate |
2014 |
| topic |
Heart Disease Echocardiography |
| url |
http://lib.ui.ac.id/file?file=digital/2015-11/20389748-T-Robert Noldy Ngantung.pdf |
| contents |
[<b>ABSTRAK</b><br>
Latar Belakang
Jaringan adiposa epikardial (JAE) sebagai jaringan adiposa visera penting peranannya
dalam proses aterosklerosis di arteri koroner. Studi sebelumnya menunjukkan ketebalan
adiposa epikardial lebih besar pada pasien dengan penyakit jantung koroner (PJK)
Tujuan
Mengetahui korelasi antara ketebalan adiposa epikardial dengan derajat stenosis arteri
koroner pada pasien PJK stabil
Metode
Dilakukan studi potong lintang pada tujuh puluh pasien PJK stabil yang menjalani
angiografi koroner. Derajat stenosis arteri koroner dinilai dengan skor Gensini > 40
(berat) dan ≤ 40 (ringan-sedang). Ketebalan adiposa epikardial dinilai dengan
ekokardiografi transtorakal pada fase sistolik akhir tampilan parasternal long axis.
Hasil
Nilai rerata ketebalan adiposa epikardial adalah 5,96 mm (SB 1,76) dan nilai median
skor Gensini adalah 35,0 (kisaran 2-126). Analisis bivariat menunjukkan korelasi positif
kuat yang bermakna (r = 0,768, p < 0,001). Nilai titik potong terbaik dari ketebalan
adiposa epikardial yang memiliki nilai klinis berkaitan dengan derajat stenosis arteri
koroner berdasarkan skor Gensini adalah 6,15 mm dengan sensitivitas 85,29%,
spesifisitas 83,33%, nilai duga positif 82%, nilai duga negatif 85% dengan AUC sebesar
0,893 (IK 95% 0,814-0,971, p < 0,001).
Simpulan
Ketebalan adiposa epikardial berkorelasi signifikan dengan derajat stenosis arteri
koroner berdasarkan skor Gensini. Ketebalan adiposa epikardial 6,15 mm memiliki
kemampuan yang cukup baik untuk membedakan pasien PJK stabil ringan-sedang dan
berat berdasarkan skor gensini.
<hr>
<b>ABSTRACT</b><br>
Background:
Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role in
the atherosclerotic cardiovascular disease. Previous studies have shown that EAT is
thicker in those with coronary heart disease.
Objective:
To determine the correlation of epicardial adipose thickness with the severity of
coronary artery stenosis in stable coronary heart disease (CHD) patient
Method:
A cross-sectional study was conducted on seventy stable CHD patient undergoing
coronary angiography. Severity of coronary artery stenosis was evaluated using Gensini
scoring system : > 40 (severe) and ≤ 40 (mild-moderate). Epicardial adipose tissue was
measured using transthoracic echocardiography at end-systole from parasternal longaxis
view.
Results :
Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median value
of Gensini score was 35,0 (range 2-126). The correlation test showed a significant
strong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardial
adipose thickness which has a clinical value correlating to severity of coronary artery
stenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,
specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % and
AUC of 0,893 (CI 0,814-0,971, p < 0,001)
Conclusion :
Epicardial fat thickness is significantly correlated to the severity of coronary artery
stenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has a
good capability in discriminating mild-moderate dan severe stable CHD patient based
on Gensini scoring system, Background:
Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role in
the atherosclerotic cardiovascular disease. Previous studies have shown that EAT is
thicker in those with coronary heart disease.
Objective:
To determine the correlation of epicardial adipose thickness with the severity of
coronary artery stenosis in stable coronary heart disease (CHD) patient
Method:
A cross-sectional study was conducted on seventy stable CHD patient undergoing
coronary angiography. Severity of coronary artery stenosis was evaluated using Gensini
scoring system : > 40 (severe) and ≤ 40 (mild-moderate). Epicardial adipose tissue was
measured using transthoracic echocardiography at end-systole from parasternal longaxis
view.
Results :
Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median value
of Gensini score was 35,0 (range 2-126). The correlation test showed a significant
strong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardial
adipose thickness which has a clinical value correlating to severity of coronary artery
stenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,
specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % and
AUC of 0,893 (CI 0,814-0,971, p < 0,001)
Conclusion :
Epicardial fat thickness is significantly correlated to the severity of coronary artery
stenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has a
good capability in discriminating mild-moderate dan severe stable CHD patient based
on Gensini scoring system] |
| id |
IOS18064.20389748 |
| institution |
Universitas Indonesia |
| institution_id |
51 |
| institution_type |
library:university library |
| library |
Perpustakaan Universitas Indonesia |
| library_id |
492 |
| collection |
Repository Skripsi (open) Universitas Indonesia |
| repository_id |
18064 |
| city |
KOTA DEPOK |
| province |
JAWA BARAT |
| repoId |
IOS18064 |
| first_indexed |
2022-12-13T09:11:09Z |
| last_indexed |
2022-12-13T09:11:09Z |
| recordtype |
dc |
| merged_child_boolean |
1 |
| _version_ |
1752201824253771776 |
| score |
17.60987 |