Efek peningkatan piperin terhadap peningkatan kegiatan listrik otak tikus kejang akibat induksi oleh bicuculine = The protective effects of pipeline against EEG amplitude and frequency alterations induced by bicuculine in the rat
| Main Authors: | Ratna Pelawati, author, Add author: Nurhadi Ibrahim, supervisor, Add author: Frans D. Suyatna, supervisor, Add author: Sri Redjeki, examiner, Add author: Arini Setiawati, examiner, Add author: Purba, Jan Sudir, examiner |
|---|---|
| Format: | Masters Doctoral |
| Terbitan: |
, 2008
|
| Subjects: | |
| Online Access: |
https://lib.ui.ac.id/detail?id=20339427 |
| ctrlnum |
20339427 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><type>Thesis:Masters</type><title>Efek peningkatan piperin terhadap peningkatan kegiatan listrik otak tikus kejang akibat induksi oleh bicuculine = The protective effects of pipeline against EEG amplitude and frequency alterations induced by bicuculine in the rat</title><creator>Ratna Pelawati, author</creator><creator>Add author: Nurhadi Ibrahim, supervisor</creator><creator>Add author: Frans D. Suyatna, supervisor</creator><creator>Add author: Sri Redjeki, examiner</creator><creator>Add author: Arini Setiawati, examiner</creator><creator>Add author: Purba, Jan Sudir, examiner</creator><publisher/><date>2008</date><subject>Rats --Physiology</subject><subject>Rats --Behavior</subject><description><b>ABSTRAK</b><br>
Latar belakang : Prevalensi penyakit dengan gejala kejang di Indonesia cukup
tinggi. Sejalan dengan Iangkah strategis Universitas Indonesia untuk meneliti
tanaman herbal yang bermanfaat, maka peneiitian ini ingin menyelidiki
kemungkinan pemanfaatan piperine (ekstrak dari lada jawa) sebagai obat anti
kejang.
Tujuan : Mengetahui efek protektif piperin terhadap peningkatan kegiatan listrik
otak tikus kejang akibat induksi oleh bicuculline dilihat dari iiekuensi dan
amplitudo pada rekaman elektroensefalograii, dibandingkan kontrol.
Metode : Penelitian ini merupakan penelitian eksperimental in-vivo, dilakukan
pada empat kelompok tikus, masing-masing kelompok terdiri dari 6 tikus. Seluruh
tikus beljumlah 24 ekor, diberi induktor kejang bicuculline. Sam kelompok
kontrol tanpa diberi piperin dan tiga kelompok uji diberikan piperin dengan dosis
yang berbeda. Hewan uji yang digunakan adalah tikus Sprague Dawley jantan.
Kelompok uji dibagi menjadi tiga yaitu kelompok dosis piperin 100 mg/kgBB,
200 mg/kgBB, dan 400 mg/kgBB. Perubahan amplitudo dan frekuensi EEG
direkam pada menit ke-0, menit ke-30, menit ke-40, menit ke-50, dan menit ke-60
setelah pemberian piperin.
Hasil penelitian : Pemberian piperin dosis 100 mg/kgBB, dosis 200mg/kgBB dan
dosis 400 mg/kgBB menurunkan ampliludo dan meningkatkan frekuensi serta
menghilangkan spike pada rekaman EEG. Piperin dosis 100 mg/kgBB setelah 50
menit pemberian peroral secara bermakna meningkatkan frekuensi dan
menurunkan ampliludo.
Kesimpulan : Piperin mempunyai efek pencegahan peningkatan kegiatan Iislrik
otak dengan bukti meningkatkan frekuensi dan menunmkan amplitudo EEG.
Pemberian piperin dosis 100 mg/kgBB lebih efektif dibandingkan dosis 200
mg/kgBB dan 400 mg/kgBB.
<hr>
<b>ABSTRACT</b><br>
Background: The prevalence of disease with seizure symptom has found in
Indonesia high enough. In line with strategic plan of University of Indonesia to
encourage studies on ingenious herbs in Indonesia, the present study is directed to
investigate the possible beneficial effect of pipperine (extract java pepper) in the
treatment of seizure.
Objective: This study was conducted to investigate the protective effect of
pipperine against amplitude and frequency alterations of electroencephalogram
(EEG) induced by bicuculline in the rat.
Design of study: Twenty four male Sprague Dawley rats were used in the study,
in which the rats were grouped into 4, each consisted of 6 animals. The control
group was the rats which received oral CMC 1% (carboxy methyl cellulose), 30
minute prior to subcutaneously injected bicuculline of 2,7 mg/kgBW. The other 3
treated goups received oral piperine 100mg/kgBW, 200mg/kgBW and 400
mg/kgBW respectively, 30 minute prior to subcutaneously injected bicuculline of
2,7 mg/kgBW. The amplitude and frequency of EEG were recorded at zero time,
30?' minute, 40?? minute, 50? minute, and 60"? minute aiter the administration of
pipperine.
Result: Injected of bicuculline in the rats, caused no alterations of EEG pattern as
compared with the EEG at zero point measurement. At 20 minute after bicuculline
injection, there was an were dose of amplitude and reduce of frequency of EEG
with spike wave. Piperine at various concentrations reduced the EEG
abnormalities. Piperine of l00 mg/kgBW showed the best protective effects
against EEG alteration.
Conclution: Pipperine l00 mg/kgBW given before bicuculline reduced the
amplitude and increased the iiequency of EEG to near normal condition.</description><identifier>https://lib.ui.ac.id/detail?id=20339427</identifier><recordID>20339427</recordID></dc>
|
| format |
Thesis:Masters Thesis Thesis:Doctoral |
| author |
Ratna Pelawati, author Add author: Nurhadi Ibrahim, supervisor Add author: Frans D. Suyatna, supervisor Add author: Sri Redjeki, examiner Add author: Arini Setiawati, examiner Add author: Purba, Jan Sudir, examiner |
| title |
Efek peningkatan piperin terhadap peningkatan kegiatan listrik otak tikus kejang akibat induksi oleh bicuculine = The protective effects of pipeline against EEG amplitude and frequency alterations induced by bicuculine in the rat |
| publishDate |
2008 |
| topic |
Rats --Physiology Rats --Behavior |
| url |
https://lib.ui.ac.id/detail?id=20339427 |
| contents |
<b>ABSTRAK</b><br>
Latar belakang : Prevalensi penyakit dengan gejala kejang di Indonesia cukup
tinggi. Sejalan dengan Iangkah strategis Universitas Indonesia untuk meneliti
tanaman herbal yang bermanfaat, maka peneiitian ini ingin menyelidiki
kemungkinan pemanfaatan piperine (ekstrak dari lada jawa) sebagai obat anti
kejang.
Tujuan : Mengetahui efek protektif piperin terhadap peningkatan kegiatan listrik
otak tikus kejang akibat induksi oleh bicuculline dilihat dari iiekuensi dan
amplitudo pada rekaman elektroensefalograii, dibandingkan kontrol.
Metode : Penelitian ini merupakan penelitian eksperimental in-vivo, dilakukan
pada empat kelompok tikus, masing-masing kelompok terdiri dari 6 tikus. Seluruh
tikus beljumlah 24 ekor, diberi induktor kejang bicuculline. Sam kelompok
kontrol tanpa diberi piperin dan tiga kelompok uji diberikan piperin dengan dosis
yang berbeda. Hewan uji yang digunakan adalah tikus Sprague Dawley jantan.
Kelompok uji dibagi menjadi tiga yaitu kelompok dosis piperin 100 mg/kgBB,
200 mg/kgBB, dan 400 mg/kgBB. Perubahan amplitudo dan frekuensi EEG
direkam pada menit ke-0, menit ke-30, menit ke-40, menit ke-50, dan menit ke-60
setelah pemberian piperin.
Hasil penelitian : Pemberian piperin dosis 100 mg/kgBB, dosis 200mg/kgBB dan
dosis 400 mg/kgBB menurunkan ampliludo dan meningkatkan frekuensi serta
menghilangkan spike pada rekaman EEG. Piperin dosis 100 mg/kgBB setelah 50
menit pemberian peroral secara bermakna meningkatkan frekuensi dan
menurunkan ampliludo.
Kesimpulan : Piperin mempunyai efek pencegahan peningkatan kegiatan Iislrik
otak dengan bukti meningkatkan frekuensi dan menunmkan amplitudo EEG.
Pemberian piperin dosis 100 mg/kgBB lebih efektif dibandingkan dosis 200
mg/kgBB dan 400 mg/kgBB.
<hr>
<b>ABSTRACT</b><br>
Background: The prevalence of disease with seizure symptom has found in
Indonesia high enough. In line with strategic plan of University of Indonesia to
encourage studies on ingenious herbs in Indonesia, the present study is directed to
investigate the possible beneficial effect of pipperine (extract java pepper) in the
treatment of seizure.
Objective: This study was conducted to investigate the protective effect of
pipperine against amplitude and frequency alterations of electroencephalogram
(EEG) induced by bicuculline in the rat.
Design of study: Twenty four male Sprague Dawley rats were used in the study,
in which the rats were grouped into 4, each consisted of 6 animals. The control
group was the rats which received oral CMC 1% (carboxy methyl cellulose), 30
minute prior to subcutaneously injected bicuculline of 2,7 mg/kgBW. The other 3
treated goups received oral piperine 100mg/kgBW, 200mg/kgBW and 400
mg/kgBW respectively, 30 minute prior to subcutaneously injected bicuculline of
2,7 mg/kgBW. The amplitude and frequency of EEG were recorded at zero time,
30?' minute, 40?? minute, 50? minute, and 60"? minute aiter the administration of
pipperine.
Result: Injected of bicuculline in the rats, caused no alterations of EEG pattern as
compared with the EEG at zero point measurement. At 20 minute after bicuculline
injection, there was an were dose of amplitude and reduce of frequency of EEG
with spike wave. Piperine at various concentrations reduced the EEG
abnormalities. Piperine of l00 mg/kgBW showed the best protective effects
against EEG alteration.
Conclution: Pipperine l00 mg/kgBW given before bicuculline reduced the
amplitude and increased the iiequency of EEG to near normal condition. |
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Universitas Indonesia |
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Repository Disertasi (Membership) Universitas Indonesia |
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KOTA DEPOK |
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JAWA BARAT |
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