Hubungan Imunoekspresi E-cadherin dan C-erb B2 dengan Derajat Keganasan Histopatologik Karsinoma Kistik Adenoid Kelenjar Liur (Correlation of E-cadherin and C-erb B2 Immunoexpression with the Degree of Histopathological Malignancy on Salivary Gland Adenoid Cystic Carcinoma)
| Main Authors: | Marry Siti Mariam, Wazilah Nasserie |
|---|---|
| Format: | Book 7p |
| Terbitan: |
FK UNPAD
, 2012
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| Subjects: | |
| Online Access: |
https://perpustakaan.badankebijakan.kemkes.go.id//index.php?p=show_detail&id=34266 |
Daftar Isi:
- Adenoid cystic carcinoma (ACC) is the most common salivary gland malignancies, with high rate of local recurrence and unpredictable prognosis. Based on previous research, prognosis of ACC in salivary gland which is correlated with survival rates, is related with histopathological malignancy degree based on its growth pattern type. This study was conducted in Pathology Anatomy Department of Medical Faculty, Padjadjaran University Bandung in 2009. The aim of this study was to analyze the alteration of immunoexpression of E-cadherin (adhesion molecule of epithelial cells) and C-erbB2 proto-oncogen (the family of C-erbB/epidermal growth factor receptor) in salivary gland. Adenoid cystic carcinoma correlated with cross-sectional non-random study on 51 paraffin blocks, from patients with salivary gland ACC retrospectively. The repeated histopatologic examination was to diagnose ACC and to get data of the histopathological malignancy degree (according to Szantos and Batsakis modification), and it was continued with immunohistochemistry examination of E-cadherin and C-erbB2. The alteration of negative immunoexpression of E-cadherin (82%) had correlation significantly (p