PENGARUH WAKTU PRAPERLAKUAN SARI BUAH MENGKUDU TERHADAP WUJUD EFEK TOKSIK TEOFILIN PADA TIKUS PUTIH JANTAN
| Main Authors: | Sari, Santi Purna; Departemen Farmasi FMIPA UI, Donatus, Imono A.; Fakultas Farmasi Universitas Gadjah Mada Yogyakarta |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2017
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| Subjects: | |
| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3815 http://psr.ui.ac.id/index.php/journal/article/view/3815/633 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3815/840 |
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article-3815 |
|---|---|
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">PENGARUH WAKTU PRAPERLAKUAN SARI BUAH MENGKUDU TERHADAP WUJUD EFEK TOKSIK TEOFILIN PADA TIKUS PUTIH JANTAN</title><creator>Sari, Santi Purna; Departemen Farmasi FMIPA UI</creator><creator>Donatus, Imono A.; Fakultas Farmasi Universitas Gadjah Mada Yogyakarta</creator><subject lang="en-US">morinda juice; theophyllin; interaction; jus mengkudu; teofilin; interaksi</subject><description lang="en-US">The use of traditional medicine in Indonesia as the substitution and complementary of modern medicine for the treatment of disease may cause interactions to other therapeutic drugs in the body. This research was aimed to observe the effect of Morinda juice on theophyllin toxicity in white rats. This research was initiated by checking sample of Morinda juice including organoleptic, density and thin layer chromatography analysis. The effect of pre-treatment time of Morinda juice to theophyllin toxicity was done by taking randomized completely design using 60 male Sprague Dawley rats that were devided randomly into 5 groups. First group (control) was given 225 mg/kg BW theophyllin suspension, second to fourth groups were given 5.5 g/kg BW Morinda juice on 2, 6, 12, and 24 hours before treatment of theophyllin, then all were observed the toxic effect that appeared. The results of interaction effect have shown that the pre-treatment of Morinda juice which was given 2, 6, 12, and 24 hours before 225 mg/kg BW theophyllin&nbsp;increased number of rats death for 40, 60, 60, and 100%.</description><publisher lang="en-US">Directorate of Research and Community Engagement, Universitas Indonesia</publisher><date>2017-09-06</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://psr.ui.ac.id/index.php/journal/article/view/3815</identifier><identifier>10.7454/psr.v3i2.3815</identifier><source lang="en-US">Pharmaceutical Sciences and Research (PSR); Vol 3, No 2 (2006); 87-93</source><source>2477-0612</source><source>2407-2354</source><language>eng</language><relation>http://psr.ui.ac.id/index.php/journal/article/view/3815/633</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3815/840</relation><rights lang="en-US">Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).</rights><recordID>article-3815</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Journal:eJournal |
| author |
Sari, Santi Purna; Departemen Farmasi FMIPA UI Donatus, Imono A.; Fakultas Farmasi Universitas Gadjah Mada Yogyakarta |
| title |
PENGARUH WAKTU PRAPERLAKUAN SARI BUAH MENGKUDU TERHADAP WUJUD EFEK TOKSIK TEOFILIN PADA TIKUS PUTIH JANTAN |
| publisher |
Directorate of Research and Community Engagement, Universitas Indonesia |
| publishDate |
2017 |
| topic |
morinda juice theophyllin interaction jus mengkudu teofilin interaksi |
| url |
http://psr.ui.ac.id/index.php/journal/article/view/3815 http://psr.ui.ac.id/index.php/journal/article/view/3815/633 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3815/840 |
| contents |
The use of traditional medicine in Indonesia as the substitution and complementary of modern medicine for the treatment of disease may cause interactions to other therapeutic drugs in the body. This research was aimed to observe the effect of Morinda juice on theophyllin toxicity in white rats. This research was initiated by checking sample of Morinda juice including organoleptic, density and thin layer chromatography analysis. The effect of pre-treatment time of Morinda juice to theophyllin toxicity was done by taking randomized completely design using 60 male Sprague Dawley rats that were devided randomly into 5 groups. First group (control) was given 225 mg/kg BW theophyllin suspension, second to fourth groups were given 5.5 g/kg BW Morinda juice on 2, 6, 12, and 24 hours before treatment of theophyllin, then all were observed the toxic effect that appeared. The results of interaction effect have shown that the pre-treatment of Morinda juice which was given 2, 6, 12, and 24 hours before 225 mg/kg BW theophyllin increased number of rats death for 40, 60, 60, and 100%. |
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