Sodium Benzoate is Associated with Salmonella typhi Resistant to Chloramphenicol
| Main Authors: | Jonny K Fajar; Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Darussalam, Banda Aceh 23111, Retno A Puspitasari; School of Medicine, Islamic University of Malang, Malang 65144, Ariani R Dewi; Departmen of Ophthalmology, School of Medicine, Islamic University of Malang, Malang 65144, Arif Yahya; Medical Research Unit, Scholl of Medicine, Islamic University of Malang, Malang 65144, Jay R Anand; Departmen of Pharmacology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781006 |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Public Services Universitas Indonesia
, 2016
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| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/health/article/view/5600 |
| ctrlnum |
article-5600 |
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| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Sodium Benzoate is Associated with Salmonella typhi Resistant to Chloramphenicol</title><creator>Jonny K Fajar; Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Darussalam, Banda Aceh 23111</creator><creator>Retno A Puspitasari; School of Medicine, Islamic University of Malang, Malang 65144</creator><creator>Ariani R Dewi; Departmen of Ophthalmology, School of Medicine, Islamic University of Malang, Malang 65144</creator><creator>Arif Yahya; Medical Research Unit, Scholl of Medicine, Islamic University of Malang, Malang 65144</creator><creator>Jay R Anand; Departmen of Pharmacology, National Institute of Pharmaceutical Education and Research, Guwahati,
Assam 781006</creator><subject lang="en-US"/><subject lang="en-US">Salmonella typhi; chloramphenicol; sodium benzoate; drug resistance</subject><description lang="en-US">Objective:Objective: There are many factors that govern growth and resistant of Salmonella typhi. A study had reported that the use of sodium benzoate caused antibiotic resistant. However, no study has directly evaluated the effect of sodium benzoate exposure on S. typhi sensitivity to chloramphenicol. The aim of this study was to evaluate the resistance or sensitivity of S. typhi to chloramphenicol after sodium benzoate exposure. Methods: The study was conducted in seven groups: three treatment groups (sodium benzoate insensitive S. typhi+8 &micro;g/mL, 16 &micro;g/mL, and 32 &micro;g/mL of chloramphenicol), three positive control groups (sodium benzoate sensitive S. typhi+8 &micro;g/mL, 16 &micro;g/mL, and 32 &micro;g/mL of chloramphenicol), and one negative control groups (sodium benzoate sensitive S. typhi+0 &micro;g/mL of chloramphenicol). The effect of sodium benzoate exposure to S. typhi sensitivity to chloramphenicol was measured after 24 hours. Spearman test was used to analyzed this association. Results: In this study, we found that the average S. typhi growth in the treatment groups (A, B, C) was 445 CFU/mL, 385 CFU/mL, and 171 CFU/mL, respectively. While in the positive control group (D, E, F) was not obtained any S. typhi growth. Average S. typhi growth in the negative control group was 430 CFU/mL. We found that sodium benzoate exposure inhibited S. typhi growth and affected S. typhi sensitivity to chloramphenicol (p&lt;0.05). In addition, we found that 32 &micro;g/mL chloramphenicol had the highest mean difference value, so this showed that the dose 32 &micro;g/mL of chloramphenicol had the best effectiveness of various treatment groups (p&lt;0.05). Conclusions: Sodium benzoate exposure can inhibit S. typhi growth and cause S. typhi resistant to chloramphenicol.</description><publisher lang="en-US">Directorate of Research and Public Services Universitas Indonesia</publisher><contributor lang="en-US"/><date>2016-04-13</date><type>Other:</type><type>Other:</type><type>File:application/pdf</type><identifier>http://journal.ui.ac.id/index.php/health/article/view/5600</identifier><source lang="en-US">Makara Journal of Health Research; Vol 20, No 1 (2016): April; 1-5</source><language>eng</language><rights> Journal Publishing Agreement (JPA)&nbsp;Makara Journal of Health Research (MJHR) &nbsp;Your written acceptance of this JPA is required before the article can be published. MJHR reserves all rights to the published scientific manuscript. Please read this form carefully and sign it if you agree to its terms. The signed JPA should be sent to editor_msk@ui.ac.id. &nbsp;AuthorshipAs the corresponding author, I certify on behalf of all of the authors that:The article is an original work and does not involve fraud, fabrication, or plagiarism.The article has not been published previously and is not currently under consideration for 
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|
| language |
eng |
| format |
Other: Other File:application/pdf File Journal:eJournal Journal |
| author |
Jonny K Fajar; Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Darussalam, Banda Aceh 23111 Retno A Puspitasari; School of Medicine, Islamic University of Malang, Malang 65144 Ariani R Dewi; Departmen of Ophthalmology, School of Medicine, Islamic University of Malang, Malang 65144 Arif Yahya; Medical Research Unit, Scholl of Medicine, Islamic University of Malang, Malang 65144 Jay R Anand; Departmen of Pharmacology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781006 |
| title |
Sodium Benzoate is Associated with Salmonella typhi Resistant to Chloramphenicol |
| publisher |
Directorate of Research and Public Services Universitas Indonesia |
| publishDate |
2016 |
| topic |
Salmonella typhi chloramphenicol sodium benzoate drug resistance |
| url |
http://journal.ui.ac.id/index.php/health/article/view/5600 |
| contents |
Objective:Objective: There are many factors that govern growth and resistant of Salmonella typhi. A study had reported that the use of sodium benzoate caused antibiotic resistant. However, no study has directly evaluated the effect of sodium benzoate exposure on S. typhi sensitivity to chloramphenicol. The aim of this study was to evaluate the resistance or sensitivity of S. typhi to chloramphenicol after sodium benzoate exposure. Methods: The study was conducted in seven groups: three treatment groups (sodium benzoate insensitive S. typhi+8 µg/mL, 16 µg/mL, and 32 µg/mL of chloramphenicol), three positive control groups (sodium benzoate sensitive S. typhi+8 µg/mL, 16 µg/mL, and 32 µg/mL of chloramphenicol), and one negative control groups (sodium benzoate sensitive S. typhi+0 µg/mL of chloramphenicol). The effect of sodium benzoate exposure to S. typhi sensitivity to chloramphenicol was measured after 24 hours. Spearman test was used to analyzed this association. Results: In this study, we found that the average S. typhi growth in the treatment groups (A, B, C) was 445 CFU/mL, 385 CFU/mL, and 171 CFU/mL, respectively. While in the positive control group (D, E, F) was not obtained any S. typhi growth. Average S. typhi growth in the negative control group was 430 CFU/mL. We found that sodium benzoate exposure inhibited S. typhi growth and affected S. typhi sensitivity to chloramphenicol (p<0.05). In addition, we found that 32 µg/mL chloramphenicol had the highest mean difference value, so this showed that the dose 32 µg/mL of chloramphenicol had the best effectiveness of various treatment groups (p<0.05). Conclusions: Sodium benzoate exposure can inhibit S. typhi growth and cause S. typhi resistant to chloramphenicol. |
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Universitas Indonesia |
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Perpustakaan Universitas Indonesia |
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2205 |
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Kesehatan dan Kedokteran |
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KOTA DEPOK |
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JAWA BARAT |
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IOS2205 |
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