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Small Intestinal Bacterial Overgrowth (SIBO): Result of Altered Defensive Mechanism in Gastrointestinal – A Review

Main Authors: Kurniawan, Alvin Hartanto, Gunawan, Vania Azalia, Suwandi, Benedictus Hanjaya, Kholili, Ulfa
Format: Article info application/pdf eJournal
Bahasa: eng
Terbitan: The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy , 2020
Subjects:
SIBO
management
bacterial overgrowth
breath test
rifaximin
Online Access: http://www.ina-jghe.com/journal/index.php/jghe/article/view/739
http://www.ina-jghe.com/journal/index.php/jghe/article/view/739/618
ctrlnum article-739
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Small Intestinal Bacterial Overgrowth (SIBO): Result of Altered Defensive Mechanism in Gastrointestinal &#x2013; A Review</title><creator>Kurniawan, Alvin Hartanto</creator><creator>Gunawan, Vania Azalia</creator><creator>Suwandi, Benedictus Hanjaya</creator><creator>Kholili, Ulfa</creator><subject lang="en-US"/><subject lang="en-US">SIBO; management; bacterial overgrowth; breath test; rifaximin</subject><subject lang="en-US"/><description lang="en-US">Small intestinal bacterial overgrowth (SIBO) is a condition that is characterized by an increased number of bacteria in the small intestine or an existence of bacteria type that generally should not be in the small intestine. In SIBO, the number of bacteria found in culture was more than 105 CFU (Colony-Forming unit) per ml. The fundamental problem in which SIBO occurred was the disruption in defensive mechanisms to prevent bacteria from overgrowing, including gastric acid juice, intestine motility, competent immune function, and intact anatomy. Disruption of this defensive mechanism will lead to SIBO, which furthermore will result in not only mild complications, such as abdominal complaints, but also severe complications, such as maldigestion/malabsorption, nutrient deficiency, or even systemic infection and acidosis. The manifestations of SIBO were often unclear so that it is hard to distinguish with other diseases, which much lead to misdiagnosis or underdiagnosis. Diagnosis of SIBO should be conducted very meticulously regarding underlying diseases that resulted in gastrointestinal defensive mechanism disturbance and malassimilation syndrome. Additional examinations for SIBO currently were jejunal aspiration and breath test, but both of them had their limitations in sensitivity and specificity. Therapeutical management consisted of treating the underlying diseases, eradicating bacteria with the antibiotic, particularly rifaximin, and improving nutritional deficiency.</description><publisher lang="en-US">The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy</publisher><contributor lang="en-US"/><date>2020-05-21</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://www.ina-jghe.com/journal/index.php/jghe/article/view/739</identifier><identifier>10.24871/211202038-44</identifier><source lang="en-US">The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy; Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, APRIL 2020; 38-44</source><source>2302-8181</source><source>1411-4801</source><language>eng</language><relation>http://www.ina-jghe.com/journal/index.php/jghe/article/view/739/618</relation><rights lang="en-US">Copyright (c) 2020 The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy</rights><recordID>article-739</recordID></dc>
language eng
format Journal:Article
Journal
Other:info:eu-repo/semantics/publishedVersion
Other
Other:
File:application/pdf
File
Journal:eJournal
author Kurniawan, Alvin Hartanto
Gunawan, Vania Azalia
Suwandi, Benedictus Hanjaya
Kholili, Ulfa
title Small Intestinal Bacterial Overgrowth (SIBO): Result of Altered Defensive Mechanism in Gastrointestinal – A Review
publisher The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
publishDate 2020
isbn 21120203844
topic SIBO
management
bacterial overgrowth
breath test
rifaximin
url http://www.ina-jghe.com/journal/index.php/jghe/article/view/739
http://www.ina-jghe.com/journal/index.php/jghe/article/view/739/618
contents Small intestinal bacterial overgrowth (SIBO) is a condition that is characterized by an increased number of bacteria in the small intestine or an existence of bacteria type that generally should not be in the small intestine. In SIBO, the number of bacteria found in culture was more than 105 CFU (Colony-Forming unit) per ml. The fundamental problem in which SIBO occurred was the disruption in defensive mechanisms to prevent bacteria from overgrowing, including gastric acid juice, intestine motility, competent immune function, and intact anatomy. Disruption of this defensive mechanism will lead to SIBO, which furthermore will result in not only mild complications, such as abdominal complaints, but also severe complications, such as maldigestion/malabsorption, nutrient deficiency, or even systemic infection and acidosis. The manifestations of SIBO were often unclear so that it is hard to distinguish with other diseases, which much lead to misdiagnosis or underdiagnosis. Diagnosis of SIBO should be conducted very meticulously regarding underlying diseases that resulted in gastrointestinal defensive mechanism disturbance and malassimilation syndrome. Additional examinations for SIBO currently were jejunal aspiration and breath test, but both of them had their limitations in sensitivity and specificity. Therapeutical management consisted of treating the underlying diseases, eradicating bacteria with the antibiotic, particularly rifaximin, and improving nutritional deficiency.
id IOS2619.article-739
institution Indonesian Association for the Study of Liver
institution_id 280
institution_type library:special
library
library Indonesian Association for the Study of Liver Library
library_id 69
collection The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
repository_id 2619
subject_area Diseases of Stomach, Gastroenterology/Penyakit pada Perut, Gastroenterologi
Diseases of Liver, Hepatology/Penyakit pada Liver, Hepatologi
Diseases of Endocrine Systems, Endocrinology/Penyakit-penyakit pada Pembentukan Darah, Limpa,
Diseases of Digestive Sistems/Penyakit pada Sistem Pencernaan
city JAKARTA PUSAT
province DKI JAKARTA
repoId IOS2619
first_indexed 2020-05-21T23:30:01Z
last_indexed 2020-05-21T23:30:01Z
recordtype dc
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score 17.610611

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