PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12 TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-6 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1 (Studi di KSM Pulmonologi & Ilmu Kedokteran Respirasi RS UNAIR Surabaya serta Puskesmas di Lingkungan Dinas Kesehatan Kota Surabaya)
| Main Author: | Lintang Bismantara G.P.S. S. Farm., Apt., 051315153027 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2017
|
| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/70483/1/ABSTRAK.pdf http://repository.unair.ac.id/70483/2/TFK%2003-18%20Dju%20a.pdf http://repository.unair.ac.id/70483/ http://lib.unair.ac.id |
| ctrlnum |
70483 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://repository.unair.ac.id/70483/</relation><title>PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12
TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-6 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1
(Studi di KSM Pulmonologi & Ilmu Kedokteran Respirasi RS UNAIR Surabaya serta Puskesmas di Lingkungan Dinas Kesehatan Kota Surabaya)</title><creator>Lintang Bismantara G.P.S. S. Farm., Apt., 051315153027</creator><subject>RS Pharmacy and materia medica</subject><description>ABSTRACT
Background : The supplementation of probiotics and vitamin B1, B6, B12 had been shown
to provide benefits for improving the immune system during respiratory infections, such as
pneumonia and TB. The cytokines are part of immune system that functions as the TB
pathomechanism, IFN-γ and IL-6 are cytokines that have local and systemic effects to
eliminate tuberculosis bacteria.
Objectives : To analyse the effect of probiotics and vitamin B1, B6 and B12 supplementation
on plasma levels of IFN-γ and IL-6 in TB patients with first line oral antituberculosis.
Method : This study was an observational, pre-post test randomised control within
November 2016 until January 2017 and it had been reviewed by the Ethics Committee of Dr
Soetomo Teaching Hospital. Plasma levels were determined by ELISA method. Blood
samples were taken as much as three times before treatment, after a month and two months.
Result : There were 22 samples which were divided into the control group (11 samples) and
the treatment group with supplementations (11 samples). Patients characteristic were
homogeneous between both groups. After a month observation, the mean level of IFN-γ
increased in both groups (p = 0.18) then decreased dramatically especially in treatment group
(p = 0.01). The mean levels of IL-6 during the study trend to decreased in both groups such
as after a month in the control group (p = 0.02) and treatment group (p = 0.04).
Conclusion : The mean level of IFN-γ was increased greater, and declining trend of IL-6
were lower in patients using supplementation after a month.</description><date>2017</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><type>Book:Book</type><language>ind</language><identifier>http://repository.unair.ac.id/70483/1/ABSTRAK.pdf</identifier><type>Book:Book</type><language>ind</language><identifier>http://repository.unair.ac.id/70483/2/TFK%2003-18%20Dju%20a.pdf</identifier><identifier> Lintang Bismantara G.P.S. S. Farm., Apt., 051315153027 (2017) PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12 TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-6 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1 (Studi di KSM Pulmonologi & Ilmu Kedokteran Respirasi RS UNAIR Surabaya serta Puskesmas di Lingkungan Dinas Kesehatan Kota Surabaya). Thesis thesis, Universitas Airlangga. </identifier><relation>http://lib.unair.ac.id</relation><recordID>70483</recordID></dc>
|
| language |
ind |
| format |
Thesis:Thesis Thesis PeerReview:NonPeerReviewed PeerReview Book:Book Book |
| author |
Lintang Bismantara G.P.S. S. Farm., Apt., 051315153027 |
| title |
PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12
TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-6 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1
(Studi di KSM Pulmonologi & Ilmu Kedokteran Respirasi RS UNAIR Surabaya serta Puskesmas di Lingkungan Dinas Kesehatan Kota Surabaya) |
| publishDate |
2017 |
| isbn |
051315153027 |
| topic |
RS Pharmacy and materia medica |
| url |
http://repository.unair.ac.id/70483/1/ABSTRAK.pdf http://repository.unair.ac.id/70483/2/TFK%2003-18%20Dju%20a.pdf http://repository.unair.ac.id/70483/ http://lib.unair.ac.id |
| contents |
ABSTRACT
Background : The supplementation of probiotics and vitamin B1, B6, B12 had been shown
to provide benefits for improving the immune system during respiratory infections, such as
pneumonia and TB. The cytokines are part of immune system that functions as the TB
pathomechanism, IFN-γ and IL-6 are cytokines that have local and systemic effects to
eliminate tuberculosis bacteria.
Objectives : To analyse the effect of probiotics and vitamin B1, B6 and B12 supplementation
on plasma levels of IFN-γ and IL-6 in TB patients with first line oral antituberculosis.
Method : This study was an observational, pre-post test randomised control within
November 2016 until January 2017 and it had been reviewed by the Ethics Committee of Dr
Soetomo Teaching Hospital. Plasma levels were determined by ELISA method. Blood
samples were taken as much as three times before treatment, after a month and two months.
Result : There were 22 samples which were divided into the control group (11 samples) and
the treatment group with supplementations (11 samples). Patients characteristic were
homogeneous between both groups. After a month observation, the mean level of IFN-γ
increased in both groups (p = 0.18) then decreased dramatically especially in treatment group
(p = 0.01). The mean levels of IL-6 during the study trend to decreased in both groups such
as after a month in the control group (p = 0.02) and treatment group (p = 0.04).
Conclusion : The mean level of IFN-γ was increased greater, and declining trend of IL-6
were lower in patients using supplementation after a month. |
| id |
IOS3215.70483 |
| institution |
Universitas Airlangga |
| institution_id |
33 |
| institution_type |
library:university library |
| library |
Perpustakaan Universitas Airlangga |
| library_id |
468 |
| collection |
Airlangga Institutional Repositories |
| repository_id |
3215 |
| subject_area |
Adat Istiadat Administrasi Negara dan Militer Agama |
| city |
KOTA SURABAYA |
| province |
JAWA TIMUR |
| repoId |
IOS3215 |
| first_indexed |
2018-03-10T00:37:12Z |
| last_indexed |
2018-04-01T01:29:54Z |
| recordtype |
dc |
| _version_ |
1683187844899667968 |
| score |
17.60897 |