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THE EFFECT OF ETHANOLIC EXTRACT OF CENTELLA ASIATICA (L) URBAN ADMINISTRATION TOWARDS THE THICKNESS OF PYRAMIDAL LAYER IN THE CA1 REGION OF HIPPOCAMPUS OF SPRAGUE DAWLEY RATS AFTER CHRONIC RESTRAIN STRESS

Main Authors: Wulan, Anggraeni Janar, Wasita, Brian, Wiyono, Nanang
Format: Article info application/pdf eJournal
Bahasa: eng
Terbitan: Fakultas Kedokteran Universitas Lampung , 2014
Subjects:
C. asiatica
chronic restrain stress
fluoxetin
pyramidal layer
stress
Online Access: http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662
http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662/666
ctrlnum article-662
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">THE EFFECT OF ETHANOLIC EXTRACT OF CENTELLA ASIATICA (L) URBAN ADMINISTRATION TOWARDS THE THICKNESS OF PYRAMIDAL LAYER IN THE CA1 REGION OF HIPPOCAMPUS OF SPRAGUE DAWLEY RATS AFTER CHRONIC RESTRAIN STRESS</title><creator>Wulan, Anggraeni Janar</creator><creator>Wasita, Brian</creator><creator>Wiyono, Nanang</creator><subject lang="en-US">C. asiatica, chronic restrain stress, fluoxetin, pyramidal layer, stress</subject><description lang="en-US">Background: Stress has been shown can change the structure of the brain, especially in the cornu ammonic (CA) I region of hippocampus. Centella asiatica or pegagan as herbal neuroprotector was investigated. The study aimed to determine the effect of ethanolic extract of C. asiatica to the thickness of pyramidal layer in the CA1 region in rats subjected to chronic restrain stress (CRS). Method: This experimental study used post test only group design. Thirty five rats were divided into 6 groups: non stress group (control) and stress only group pulvis gum arabicum (PGA), positive control group (treated with fluoxetin 10mg/kgBW), and 3 treatment groups are treated with C. asiatica 150, 300, and 600mg/kgBW respectively. All groups except non stress group were subjected to CRS, for 6 hours per day for 21 days. Fluoxetin, PGA, and C. Asiatica were applied 30 minutes before CRS done. Rats were sacrificed at the end of 24th day and were perfused transcardially. Processed brain tissue stained with toluidine blue, and measured with Image Raster program. Result: The thickness of pyramidal layer in the CA1 region are increasing significantly in treatment groups which treated with 150 and 300 kg/BW of C. asiatica, but not significant which treated with 600mg/kgBW ethanolic extract of C. asiatica. Conclusion: Ethanolic extract of C. asiatica can improve thickness of pyramidal layer in the CA1 region of hippocampus of Sprague Dawley rats after chronic restrain stress. [JuKe Unila 2014; 4(8):202-207]</description><publisher lang="en-US">Fakultas Kedokteran Universitas Lampung</publisher><contributor lang="en-US"/><date>2014-09-11</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662</identifier><source lang="en-US">JUKE Unila; Vol 4, No 8 (2014); 202-207</source><source>2088-9348</source><language>eng</language><relation>http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662/666</relation><recordID>article-662</recordID></dc>
language eng
format Journal:Article
Journal
Other:info:eu-repo/semantics/publishedVersion
Other
Other:
File:application/pdf
File
Journal:eJournal
author Wulan, Anggraeni Janar
Wasita, Brian
Wiyono, Nanang
title THE EFFECT OF ETHANOLIC EXTRACT OF CENTELLA ASIATICA (L) URBAN ADMINISTRATION TOWARDS THE THICKNESS OF PYRAMIDAL LAYER IN THE CA1 REGION OF HIPPOCAMPUS OF SPRAGUE DAWLEY RATS AFTER CHRONIC RESTRAIN STRESS
publisher Fakultas Kedokteran Universitas Lampung
publishDate 2014
topic C. asiatica
chronic restrain stress
fluoxetin
pyramidal layer
stress
url http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662
http://juke.kedokteran.unila.ac.id/index.php/juke/article/view/662/666
contents Background: Stress has been shown can change the structure of the brain, especially in the cornu ammonic (CA) I region of hippocampus. Centella asiatica or pegagan as herbal neuroprotector was investigated. The study aimed to determine the effect of ethanolic extract of C. asiatica to the thickness of pyramidal layer in the CA1 region in rats subjected to chronic restrain stress (CRS). Method: This experimental study used post test only group design. Thirty five rats were divided into 6 groups: non stress group (control) and stress only group pulvis gum arabicum (PGA), positive control group (treated with fluoxetin 10mg/kgBW), and 3 treatment groups are treated with C. asiatica 150, 300, and 600mg/kgBW respectively. All groups except non stress group were subjected to CRS, for 6 hours per day for 21 days. Fluoxetin, PGA, and C. Asiatica were applied 30 minutes before CRS done. Rats were sacrificed at the end of 24th day and were perfused transcardially. Processed brain tissue stained with toluidine blue, and measured with Image Raster program. Result: The thickness of pyramidal layer in the CA1 region are increasing significantly in treatment groups which treated with 150 and 300 kg/BW of C. asiatica, but not significant which treated with 600mg/kgBW ethanolic extract of C. asiatica. Conclusion: Ethanolic extract of C. asiatica can improve thickness of pyramidal layer in the CA1 region of hippocampus of Sprague Dawley rats after chronic restrain stress. [JuKe Unila 2014; 4(8):202-207]
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