EFFECT OF PENTAGAMAVUNON-0 TO THE THEOPHYLLINE PHARMACOKINETICS IN RATS
| Main Authors: | Hakim, Arief Rahman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University, Hakim, Lukman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University, Margono, Supardjan A.; Department of Chemistry, Faculty of Pharmacy, Gadjah Mada University |
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| Format: | Article info Journal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2005
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731/592 |
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article-731 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">EFFECT OF PENTAGAMAVUNON-0 TO THE THEOPHYLLINE PHARMACOKINETICS IN RATS</title><creator>Hakim, Arief Rahman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University</creator><creator>Hakim, Lukman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University</creator><creator>Margono, Supardjan A.; Department of Chemistry, Faculty of Pharmacy, Gadjah Mada University</creator><description lang="en-US">The research was aimed to observe pentagamavunon-0 activities to theophylline pharmacokinetics in rats. The study of interaction pentagamavunon-0 and theophylline was conducted employing a completely randomized design using male Wistar rats which were divided into 5 groups (6 rats for each group). The groups were given a single oral theophylline 25 mg/kg BW as a control group and were administered single oral pentagamavunon-0 2, 5, 10 and 40 mg/kg BW each dose 4 hours before treatment with theophylline. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged theophylline in blood. The concentration of theophylline was determined based on a standard curve. The concentration-time data determines theophylline pharmacokinetics i.e. Ka, Cmaks, tmaks, AUC0-, Vdss, t1/2 elimination, Clt and MRT. The results indicated that pentagamavunon-0 was found to be able to decrease theophylline clearance 40-51% (P&lt;0.05). The decrease in clearance causes the prolonged life of theophylline in the body.Key words : Pentagamavunon-0, Theophylline, Pharmacokinetics</description><publisher lang="en-US">Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia</publisher><contributor lang="en-US"/><date>2005-01-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>Other:</type><identifier>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731</identifier><identifier>10.14499/indonesianjpharm0iss0pp244-249</identifier><source lang="en-US">INDONESIAN JOURNAL OF PHARMACY; Vol 14 No 1, 2003; 244-249</source><source>2338-9486</source><source>2338-9427</source><language>eng</language><relation>http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731/592</relation><rights lang="0">Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY</rights><rights lang="0"/><recordID>article-731</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: Journal:Journal |
| author |
Hakim, Arief Rahman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University Hakim, Lukman; Department of Pharmacological, Faculty of Pharmacy, Gadjah Mada University Margono, Supardjan A.; Department of Chemistry, Faculty of Pharmacy, Gadjah Mada University |
| title |
EFFECT OF PENTAGAMAVUNON-0 TO THE THEOPHYLLINE PHARMACOKINETICS IN RATS |
| publisher |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia |
| publishDate |
2005 |
| url |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/731/592 |
| contents |
The research was aimed to observe pentagamavunon-0 activities to theophylline pharmacokinetics in rats. The study of interaction pentagamavunon-0 and theophylline was conducted employing a completely randomized design using male Wistar rats which were divided into 5 groups (6 rats for each group). The groups were given a single oral theophylline 25 mg/kg BW as a control group and were administered single oral pentagamavunon-0 2, 5, 10 and 40 mg/kg BW each dose 4 hours before treatment with theophylline. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged theophylline in blood. The concentration of theophylline was determined based on a standard curve. The concentration-time data determines theophylline pharmacokinetics i.e. Ka, Cmaks, tmaks, AUC0-, Vdss, t1/2 elimination, Clt and MRT. The results indicated that pentagamavunon-0 was found to be able to decrease theophylline clearance 40-51% (P<0.05). The decrease in clearance causes the prolonged life of theophylline in the body.Key words : Pentagamavunon-0, Theophylline, Pharmacokinetics |
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Universitas Gadjah Mada |
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Indonesian Journal of Pharmacy |
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Pharmacology and Toxicology Pharmacokinetics Community and Clinical Pharmacy Pharmaceutical Chemistry |
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SLEMAN |
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DAERAH ISTIMEWA YOGYAKARTA |
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2017-03-20T03:51:23Z |
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2017-03-20T03:51:23Z |
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17.610476 |