Some aspects of thyroid dysfunction in thalassemia major patients with severe iron overload
| Main Authors: | Rindang, Cynthia, Batubara, Jose R. L., Amalia, Pustika, Satari, Hindra |
|---|---|
| Format: | Article info application/pdf eArticle |
| Bahasa: | eng |
| Terbitan: |
Indonesian Pediatric Society
, 2011
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| Online Access: |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889 https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889/734 |
| ctrlnum |
article-889 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Some aspects of thyroid dysfunction in thalassemia major patients with severe iron overload</title><creator>Rindang, Cynthia</creator><creator>Batubara, Jose R. L.</creator><creator>Amalia, Pustika</creator><creator>Satari, Hindra</creator><description lang="en-US">Background Severe iron overload due to recurrent transfusions for chronic anemia and inadequate iron chelation therapy in thalassemia major patients result in various complications, including hypothyroidism. Currently, there has been no data on the prevalence of hypothyroidism in thalassemia major patients at the Thalassemia Centers, Department of Child Health, CiptoMangunkusumo Hospital (DCH CMH).Objective To study the prevalence of primary hypothyroidism in thalassemia major patients in the Thalassemia Center, DCH MCH.Methods We performed a cross-sectional, descriptive study. All thalassemia major subjects aged O􀁬18 years with severe iron overload underwent thyroid functionexamination. Primary hypothyroidism was defined as either normal (compensated) or decreased (decompensated) free T4 (FT4) levels, along with elevated sensitive thyroid􀁬stimulatinghonnone (TSH)levels. Results 179 subjects enrolled this study Mth male: female ratio of 1: 1.6. The prevalence of primary hypothyroidism in thalassemia majorpatients Mth severe iron overloadws26.8% (48/179). Of those 48,45 had compensated hypothyroidism and 3 had decompensated hypothyroidism, 25.1% and 1.7% of the total subjects, respectively. Compensated hypothyroidism was observed in 17 subjects aged ≤1O years and in 28 subjects aged&gt; 10 years. All 3 decompensated hypothyroidism cases were&gt; 10 years of age. No relationship was found between the occurrence of primary hypothyroidism and mean pre-tr811sfusion Hb levels (P=0.481, OR 1.30; 95% CI 0.63 to 2.68), elevated serum ferritin levels (P=0.74, OR 0.89; 95% CI 0.46 to 1.75), and compliance to iron chelation therapy (P=0.570, OR 0.76; 95% CI 035 to 1.65). Based on multivariate analysis, only age of &lt;10 year-old (P=O.029, OR 0.469; 95% CI 0.23 to 0.93) was significantly associated Mth primary hypJthyroidism. Further analysis using receiver operator curve (ROC) technique found that age of 8.5 year-old was the cutoff value to predict the risk of hypothyroidism. Conclusion The prevalence of primary hypothyroidism in our study is high. The occurrence of hypothyroidism is associated with age.</description><publisher lang="en-US">Indonesian Pediatric Society</publisher><date>2011-04-30</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><identifier>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889</identifier><identifier>10.14238/pi51.2.2011.66-72</identifier><source lang="en-US">Paediatrica Indonesiana; Vol 51 No 2 (2011): March 2011; 66-72</source><source>2338-476X</source><source>0030-9311</source><source>10.14238/pi51.2.2011</source><language>eng</language><relation>https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889/734</relation><recordID>article-889</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other File:application/pdf File Journal:eArticle |
| author |
Rindang, Cynthia Batubara, Jose R. L. Amalia, Pustika Satari, Hindra |
| title |
Some aspects of thyroid dysfunction in thalassemia major patients with severe iron overload |
| publisher |
Indonesian Pediatric Society |
| publishDate |
2011 |
| url |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889 https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/889/734 |
| contents |
Background Severe iron overload due to recurrent transfusions for chronic anemia and inadequate iron chelation therapy in thalassemia major patients result in various complications, including hypothyroidism. Currently, there has been no data on the prevalence of hypothyroidism in thalassemia major patients at the Thalassemia Centers, Department of Child Health, CiptoMangunkusumo Hospital (DCH CMH).Objective To study the prevalence of primary hypothyroidism in thalassemia major patients in the Thalassemia Center, DCH MCH.Methods We performed a cross-sectional, descriptive study. All thalassemia major subjects aged O18 years with severe iron overload underwent thyroid functionexamination. Primary hypothyroidism was defined as either normal (compensated) or decreased (decompensated) free T4 (FT4) levels, along with elevated sensitive thyroidstimulatinghonnone (TSH)levels. Results 179 subjects enrolled this study Mth male: female ratio of 1: 1.6. The prevalence of primary hypothyroidism in thalassemia majorpatients Mth severe iron overloadws26.8% (48/179). Of those 48,45 had compensated hypothyroidism and 3 had decompensated hypothyroidism, 25.1% and 1.7% of the total subjects, respectively. Compensated hypothyroidism was observed in 17 subjects aged ≤1O years and in 28 subjects aged> 10 years. All 3 decompensated hypothyroidism cases were> 10 years of age. No relationship was found between the occurrence of primary hypothyroidism and mean pre-tr811sfusion Hb levels (P=0.481, OR 1.30; 95% CI 0.63 to 2.68), elevated serum ferritin levels (P=0.74, OR 0.89; 95% CI 0.46 to 1.75), and compliance to iron chelation therapy (P=0.570, OR 0.76; 95% CI 035 to 1.65). Based on multivariate analysis, only age of <10 year-old (P=O.029, OR 0.469; 95% CI 0.23 to 0.93) was significantly associated Mth primary hypJthyroidism. Further analysis using receiver operator curve (ROC) technique found that age of 8.5 year-old was the cutoff value to predict the risk of hypothyroidism. Conclusion The prevalence of primary hypothyroidism in our study is high. The occurrence of hypothyroidism is associated with age. |
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IOS4351.article-889 |
| institution |
Ikatan Dokter Anak Indonesia (IDAI) |
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1183 |
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library:special library |
| library |
Badan Penerbit IDAI |
| library_id |
1030 |
| collection |
Paediatrica Indonesiana |
| repository_id |
4351 |
| subject_area |
Pediatric/Pediatrik Newborn Infant, Neonates/Perawatan Bayi Baru Lahir, Neonatal |
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JAKARTA PUSAT |
| province |
DKI JAKARTA |
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IOS4351 |
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2017-07-11T01:01:14Z |
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2019-05-07T07:58:41Z |
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dc |
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1686120186318422016 |
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17.202314 |