Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung
| Main Authors: | Sagita, Erny; Departemen Farmasi Universitas Indonesia, Anwar, Effionora; Departemen Farmasi Universitas Indonesia, Surini, Silvia; Departemen Farmasi Universitas Indonesia |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2014
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| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3462 http://psr.ui.ac.id/index.php/journal/article/view/3462/540 |
| ctrlnum |
article-3462 |
|---|---|
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung</title><creator>Sagita, Erny; Departemen Farmasi Universitas Indonesia</creator><creator>Anwar, Effionora; Departemen Farmasi Universitas Indonesia</creator><creator>Surini, Silvia; Departemen Farmasi Universitas Indonesia</creator><description lang="en-US">Chitosan is a natural cationic polymer. That cationic property makes chitosan canform polyelectrolite complex (PEC) with anionic polymer. In this research, pectinwas used as anionic polymer that interact ionically with chitosan. The aim of thisresearch is to produce and characterize chitosan-pectin PEC that would be used asmatrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixedin ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The bestcondition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. Thedifferences between chitosan-pectin PEC characteristic and its origin polymer wereshown by functional group analysis, thermal analysis, swelling capacity and gelstrength. The PEC was then used as matrix in floating tablet.Keywords : chitosan, polyelectrolite complex, pectin, floating tablet</description><publisher lang="en-US">Directorate of Research and Community Engagement, Universitas Indonesia</publisher><date>2014-07-01</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://psr.ui.ac.id/index.php/journal/article/view/3462</identifier><identifier>10.7454/psr.v7i3.3462</identifier><source lang="en-US">Pharmaceutical Sciences and Research (PSR); Vol 7, No 3 (2010); 71-83</source><source>2477-0612</source><source>2407-2354</source><language>eng</language><relation>http://psr.ui.ac.id/index.php/journal/article/view/3462/540</relation><rights lang="en-US">Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).</rights><recordID>article-3462</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Journal:Journal |
| author |
Sagita, Erny; Departemen Farmasi Universitas Indonesia Anwar, Effionora; Departemen Farmasi Universitas Indonesia Surini, Silvia; Departemen Farmasi Universitas Indonesia |
| title |
Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung |
| publisher |
Directorate of Research and Community Engagement, Universitas Indonesia |
| publishDate |
2014 |
| url |
http://psr.ui.ac.id/index.php/journal/article/view/3462 http://psr.ui.ac.id/index.php/journal/article/view/3462/540 |
| contents |
Chitosan is a natural cationic polymer. That cationic property makes chitosan canform polyelectrolite complex (PEC) with anionic polymer. In this research, pectinwas used as anionic polymer that interact ionically with chitosan. The aim of thisresearch is to produce and characterize chitosan-pectin PEC that would be used asmatrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixedin ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The bestcondition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. Thedifferences between chitosan-pectin PEC characteristic and its origin polymer wereshown by functional group analysis, thermal analysis, swelling capacity and gelstrength. The PEC was then used as matrix in floating tablet.Keywords : chitosan, polyelectrolite complex, pectin, floating tablet |
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IOS4605.article-3462 |
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Universitas Indonesia |
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51 |
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library:university library |
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Perpustakaan Universitas Indonesia |
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| subject_area |
Pharmaceutical Chemistry Pharmaceutical Technology Pharmaceutical Biotechnology, Pharmacognosy and Phytochemistry Pharmacology-Toxicology, Clinical Pharmacy, Social and Administrative Pharmacy |
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KOTA DEPOK |
| province |
JAWA BARAT |
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2017-10-13T04:46:25Z |
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