VIROLOGICAL AND IMMUNOLOGICAL RESPONSE TO ANTIRETROVIRAL TREATMENT IN HIV-INFECTED PATIENTS
| Main Authors: | Intansari, Umi S, Dewi, Yunika Puspa, Juffrie, Mohammad, Soesatyo, Marsetyawan HNE, Subronto, Yanri W, Mulyono, Budi |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
|
| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/633 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/633/371 |
Daftar Isi:
- HIV/AIDS remains a significant global challenge. ART has made significant contribution by reducing viral replication, reducing morbidity from opportunistic infection, and improves the life of person living with HIV/AIDS. However there is a very limited data related with virological and immunological response including T cell activation during ART in Indonesia. The purpose of this study were to know the virological and immunological response to ARV therapy in HIV patients pre and 6 months after ART initiation. The subjects in this observational prospective study were 44 ART naive-HIV infected adults patients in RSUP Dr. Sardjito, Yogyakarta and RSUP Dr. Karyadi Hospital, Semarang. Blood samples were collected in 6 mL volume EDTA- tube, before and 6 month after ART initiation to determine the CD4 T cell count, Viral Load (VL) and percentage of CD8+/38+ T cell. Viral load was significantly decreased 6 month after ARV initiation, parallel with the percentage of CD8+/38+, while CD4 T cell was increased (p<0.0001). There were 35 (79.5%) patients obtained optimally CD4 T cells recovery (>50 cell/μL) and 9 patients were sub-optimal, after 6 months of ART initiation. Viral load were decreased more than 1 log10 copy/mL in 93% patients. We found 13.6% patients had discordance response. The VL positively correlated with CD8+/38+ cell percentage (r=0.58, p<0.0001) and negatively correlated with CD4 T cell count (r=–0.470 (p<0.0001). Based on this study we concluded, most HIV patients obtained concordance virological and immunological response 6 month after ART initiation. There were 20.45% non- responder and discordance responder patients that need to be evaluated and treated intensively.