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MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA

Main Author: Pangaribowo, Dian Agung
Format: Article info application/pdf eJournal
Bahasa: eng
Terbitan: Fakultas Kedokteran Gigi Universitas Jember , 2015
Online Access: https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044
https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044/1651
ctrlnum article-2044
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA</title><creator>Pangaribowo, Dian Agung</creator><description lang="en-US">A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)- 1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.</description><publisher lang="en-US">Fakultas Kedokteran Gigi Universitas Jember</publisher><date>2015-12-15</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>File:application/pdf</type><identifier>https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044</identifier><source lang="en-US">STOMATOGNATIC - Jurnal Kedokteran Gigi; Vol 10 No 2 (2013); 71-74</source><source>2442-4935</source><source>1693-6485</source><language>eng</language><relation>https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044/1651</relation><recordID>article-2044</recordID></dc>
language eng
format Journal:Article
Journal
Other:info:eu-repo/semantics/publishedVersion
Other
File:application/pdf
File
Journal:eJournal
author Pangaribowo, Dian Agung
title MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA
publisher Fakultas Kedokteran Gigi Universitas Jember
publishDate 2015
url https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044
https://jurnal.unej.ac.id/index.php/STOMA/article/view/2044/1651
contents A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)- 1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.
id IOS709.article-2044
institution Universitas Jember
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institution_type library:university
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library Perpustakaan Universitas Jember
library_id 516
collection STOMATOGNATIC- Jurnal Kedokteran Gigi
repository_id 709
subject_area Farmasi
city JEMBER
province JAWA TIMUR
repoId IOS709
first_indexed 2016-09-16T17:30:10Z
last_indexed 2021-12-31T12:53:43Z
recordtype dc
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