Transcriptomic analysis of a mouse model of intrahepatic cholestasis
| Main Author: | Carino, Adriana |
|---|---|
| Other Authors: | Fiorucci, Stefano, Biagioli, Michele, Marchianò, Silvia |
| Format: | Dataset |
| Terbitan: |
Mendeley
, 2019
|
| Subjects: | |
| Online Access: |
https:/data.mendeley.com/datasets/c2zvxm27yc |
| ctrlnum |
0.17632-c2zvxm27yc.1 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc><creator>Carino, Adriana</creator><title>Transcriptomic analysis of a mouse model of intrahepatic cholestasis</title><publisher>Mendeley</publisher><description>The Farnesoid X receptor (FXR), is the main bile acids sensor expressed in hepatocytes. Obeticholic acid (OCA), a fairly potent FXR agonist, has been approved for the treatment of UDCA-resistant PBC, but FXR gene ablation protects against liver injury in cholestatic modes. The use of OCA causes itching in a substantial proportion of PBC patients, and at the dose 5 mg/d, has been linked to a cluster of severe liver injury, in some cases fatal, in PBC patients with decompensated cirrhosis and Child-Pugh Class B/C. To further elucidate the role of FXR in the pathogenesis of cholestasis, we have tested the obeticholic acid alone or in combination with a FXR antagonist, named as GP7, in a mouse model of ANIT (α-naphthylisothiocyanate) induced cholestasis. OCA and GP7 intrahepatic effect were evaluated by RNAseq analysis performed on Ion S5 Sequencer with Torrent Suite Software v6.</description><subject>Gastroenterology</subject><subject>RNA Sequencing</subject><subject>Cholestasis</subject><contributor>Fiorucci, Stefano</contributor><contributor>Biagioli, Michele</contributor><contributor>Marchianò, Silvia</contributor><type>Other:Dataset</type><identifier>10.17632/c2zvxm27yc.1</identifier><rights>Creative Commons Attribution 4.0 International</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><relation>https:/data.mendeley.com/datasets/c2zvxm27yc</relation><date>2019-09-13T08:01:14Z</date><recordID>0.17632-c2zvxm27yc.1</recordID></dc>
|
| format |
Other:Dataset Other |
| author |
Carino, Adriana |
| author2 |
Fiorucci, Stefano Biagioli, Michele Marchianò, Silvia |
| title |
Transcriptomic analysis of a mouse model of intrahepatic cholestasis |
| publisher |
Mendeley |
| publishDate |
2019 |
| topic |
Gastroenterology RNA Sequencing Cholestasis |
| url |
https:/data.mendeley.com/datasets/c2zvxm27yc |
| contents |
The Farnesoid X receptor (FXR), is the main bile acids sensor expressed in hepatocytes. Obeticholic acid (OCA), a fairly potent FXR agonist, has been approved for the treatment of UDCA-resistant PBC, but FXR gene ablation protects against liver injury in cholestatic modes. The use of OCA causes itching in a substantial proportion of PBC patients, and at the dose 5 mg/d, has been linked to a cluster of severe liver injury, in some cases fatal, in PBC patients with decompensated cirrhosis and Child-Pugh Class B/C. To further elucidate the role of FXR in the pathogenesis of cholestasis, we have tested the obeticholic acid alone or in combination with a FXR antagonist, named as GP7, in a mouse model of ANIT (α-naphthylisothiocyanate) induced cholestasis. OCA and GP7 intrahepatic effect were evaluated by RNAseq analysis performed on Ion S5 Sequencer with Torrent Suite Software v6. |
| id |
IOS7969.0.17632-c2zvxm27yc.1 |
| institution |
Universitas Islam Indragiri |
| affiliation |
onesearch.perpusnas.go.id |
| institution_id |
804 |
| institution_type |
library:university library |
| library |
Teknologi Pangan UNISI |
| library_id |
2816 |
| collection |
Artikel mulono |
| repository_id |
7969 |
| city |
INDRAGIRI HILIR |
| province |
RIAU |
| shared_to_ipusnas_str |
1 |
| repoId |
IOS7969 |
| first_indexed |
2020-04-08T08:11:22Z |
| last_indexed |
2020-04-08T08:11:22Z |
| recordtype |
dc |
| _version_ |
1686587388056305664 |
| score |
17.203503 |