Algebraically in silico discovered of a multi-epitope mimic poly-pharmacophore to Multiple Peptides Derived from Cancer-Testis Antigens as a promising anti-tumor pharmaco-agent for the maintance of a Specific T-cell Response in Long-term Vaccinated patients Advanced Biliary Tract Cancer using a parallel web service for structural proteome-wide ligand-binding site comparison
| Main Author: | Ioannis Grigoriadis |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2015
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| Online Access: |
https://zenodo.org/record/31566 |
| ctrlnum |
31566 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><creator>Ioannis Grigoriadis</creator><date>2015-09-29</date><description>The prognosis of patients with advanced biliary tract cancer (BTC) is extremely poor and thereare only a few standard treatments. We conducted a phase I trial to investigate the safety, immune response,and antitumor effect of vaccination with four peptides derived from cancer-testis antigens, with a focus ontheir fluctuations during long-term vaccination until the disease had progressed. A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery. Bioinformatics, 25, i305–i312.]. These algorithms have been extensively benchmarked and shown to outperform most existing algorithms. Moreover, several predictions resulting from SMAP-WS have been validated experimentally. Thus far SMAP-WS has been applied to predict drug side effects, and to repurpose existing drugs for new indications. SMAP-WS provides both a user-friendly web interface and programming API for scientists to address a wide range of compute intense questions in biology and drug discovery. Here, we have for the first time discovered a multi-epitope mimic poly-pharmacophore to Multiple Peptides Derived from Cancer-Testis Antigens for the maintance of a Specific T-cell Response in Long-term Vaccinated patients with Advanced Biliary Tract Cancer using the BiogenetoligandorolTM based SMAP-WS chemical informatic parallel web service for structural proteome-wide ligand-binding site comparison.</description><identifier>https://zenodo.org/record/31566</identifier><identifier>10.5281/zenodo.31566</identifier><identifier>oai:zenodo.org:31566</identifier><rights>info:eu-repo/semantics/closedAccess</rights><title>Algebraically in silico discovered of a multi-epitope mimic poly-pharmacophore to Multiple Peptides Derived from Cancer-Testis Antigens as a promising anti-tumor pharmaco-agent for the maintance of a Specific T-cell Response in Long-term Vaccinated patients Advanced Biliary Tract Cancer using a parallel web service for structural proteome-wide ligand-binding site comparison.</title><type>Journal:Article</type><type>Journal:Article</type><recordID>31566</recordID></dc>
|
| format |
Journal:Article Journal Journal:Journal |
| author |
Ioannis Grigoriadis |
| title |
Algebraically in silico discovered of a multi-epitope mimic poly-pharmacophore to Multiple Peptides Derived from Cancer-Testis Antigens as a promising anti-tumor pharmaco-agent for the maintance of a Specific T-cell Response in Long-term Vaccinated patients Advanced Biliary Tract Cancer using a parallel web service for structural proteome-wide ligand-binding site comparison |
| publishDate |
2015 |
| url |
https://zenodo.org/record/31566 |
| contents |
The prognosis of patients with advanced biliary tract cancer (BTC) is extremely poor and thereare only a few standard treatments. We conducted a phase I trial to investigate the safety, immune response,and antitumor effect of vaccination with four peptides derived from cancer-testis antigens, with a focus ontheir fluctuations during long-term vaccination until the disease had progressed. A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery. Bioinformatics, 25, i305–i312.]. These algorithms have been extensively benchmarked and shown to outperform most existing algorithms. Moreover, several predictions resulting from SMAP-WS have been validated experimentally. Thus far SMAP-WS has been applied to predict drug side effects, and to repurpose existing drugs for new indications. SMAP-WS provides both a user-friendly web interface and programming API for scientists to address a wide range of compute intense questions in biology and drug discovery. Here, we have for the first time discovered a multi-epitope mimic poly-pharmacophore to Multiple Peptides Derived from Cancer-Testis Antigens for the maintance of a Specific T-cell Response in Long-term Vaccinated patients with Advanced Biliary Tract Cancer using the BiogenetoligandorolTM based SMAP-WS chemical informatic parallel web service for structural proteome-wide ligand-binding site comparison. |
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IOS16997.31566 |
| institution |
ZAIN Publications |
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7213 |
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library:special library |
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Cognizance Journal of Multidisciplinary Studies |
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5267 |
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Cognizance Journal of Multidisciplinary Studies |
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16997 |
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Multidisciplinary |
| city |
Stockholm |
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INTERNASIONAL |
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1 |
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IOS16997 |
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2022-06-06T03:35:59Z |
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2022-06-06T03:35:59Z |
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17.60897 |