Formulation of Ranitidine HCl Microcapsules with Ethyl Cellulose Using a Factorial Design
| Main Authors: | Fitriani, Lili, Rahmi, Ulfi, Ben, Elfi Sahlan |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Andalas
, 2015
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| Subjects: | |
| Online Access: |
http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18 http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18/14 |
| ctrlnum |
article-18 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Formulation of Ranitidine HCl Microcapsules with Ethyl Cellulose Using a Factorial Design</title><title lang="id-ID">Formulasi Mikrokapsul Ranitidin HCl Menggunakan Rancangan Faktorial dengan Penyalut Etil Selulosa</title><creator>Fitriani, Lili</creator><creator>Rahmi, Ulfi</creator><creator>Ben, Elfi Sahlan</creator><subject lang="id-ID"/><subject lang="id-ID">mikrokapsul; ranitidin HCl; efisiensi penjerapan; pelepasan mikrokapsul.</subject><subject lang="en-US">microcapsules; ranitidine HCl; entrapment efficiency; microcapsule release.</subject><description lang="en-US">Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours.</description><description lang="id-ID">Ranitidin HCl adalah H2-antagonis histamin yang digunakan dalam pengobatan ulkus lambung dan duodenum. Formulasi mikrokapsul ranitiditin HCl ditujukan untuk memperpanjang regimen dosis untuk meningkatkan bioavailabilitas dan waktu paruh. Tujuan dari penelitian untuk merumuskan dan mengoptimalkan mikrokapsul ranitidin HCl untuk menyiapkan sistem pelepasan yang sesuai dengan desain faktorial. Mikrokapsul disusun menggunakan etilselulosa dengan teknik penguapan pelarut. Variasi konsentrasi penstabil Span 80 (1-2%) dan rasio obat/polimer (2: 2-1: 2) dilakukan untuk mengamati efek efisiensi penjerapan. Analisis data menunjukkan bahwa mikrokapsul dengan efisiensi penjerapan optimal didapatkan pada formula yang mengandung 2% span 80, dan 1:2 rasio obat/polimer. Hasil penelitian menunjukkan mikrokapsul berbentuk sferis, dan berpori, dengan waktu pelepasan hingga 10,55 jam.</description><publisher lang="id-ID">Fakultas Farmasi Universitas Andalas</publisher><contributor lang="en-US"/><contributor lang="id-ID"/><date>2015-02-06</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><identifier>http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18</identifier><identifier>10.29208/jsfk.2014.1.1.18</identifier><source lang="en-US">Jurnal Sains Farmasi & Klinis; Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014; 101-110</source><source lang="id-ID">JSFK (Jurnal Sains Farmasi & Klinis); Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014; 101-110</source><source>2442-5435</source><source>2407-7062</source><language>ind</language><relation>http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18/14</relation><rights lang="id-ID">##submission.copyrightStatement##</rights><recordID>article-18</recordID></dc>
|
| language |
ind |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other File:application/pdf File Journal:eJournal |
| author |
Fitriani, Lili Rahmi, Ulfi Ben, Elfi Sahlan |
| title |
Formulation of Ranitidine HCl Microcapsules with Ethyl Cellulose Using a Factorial Design |
| publisher |
Fakultas Farmasi Universitas Andalas |
| publishDate |
2015 |
| topic |
mikrokapsul ranitidin HCl efisiensi penjerapan pelepasan mikrokapsul microcapsules ranitidine HCl entrapment efficiency microcapsule release |
| url |
http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18 http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/18/14 |
| contents |
Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours. Ranitidin HCl adalah H2-antagonis histamin yang digunakan dalam pengobatan ulkus lambung dan duodenum. Formulasi mikrokapsul ranitiditin HCl ditujukan untuk memperpanjang regimen dosis untuk meningkatkan bioavailabilitas dan waktu paruh. Tujuan dari penelitian untuk merumuskan dan mengoptimalkan mikrokapsul ranitidin HCl untuk menyiapkan sistem pelepasan yang sesuai dengan desain faktorial. Mikrokapsul disusun menggunakan etilselulosa dengan teknik penguapan pelarut. Variasi konsentrasi penstabil Span 80 (1-2%) dan rasio obat/polimer (2: 2-1: 2) dilakukan untuk mengamati efek efisiensi penjerapan. Analisis data menunjukkan bahwa mikrokapsul dengan efisiensi penjerapan optimal didapatkan pada formula yang mengandung 2% span 80, dan 1:2 rasio obat/polimer. Hasil penelitian menunjukkan mikrokapsul berbentuk sferis, dan berpori, dengan waktu pelepasan hingga 10,55 jam. |
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IOS3093.article-18 |
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Ikatan Apoteker Indonesia - Sumatera Barat |
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345 |
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library:special library |
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Perpustakaan Ikatan Apoteker Indonesia - Sumatera Barat |
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62 |
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Jurnal Sains Farmasi dan Klinis |
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3093 |
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Practical Pharmacy/Farmasi Praktis Sains Farmasi Kimia Farmasi Biologi Farmasi |
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KOTA PADANG |
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SUMATERA BARAT |
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IOS3093 |
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2016-10-02T16:45:14Z |
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2019-07-03T03:16:41Z |
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dc |
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1685885232050339840 |
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17.60897 |