KAJIAN STRUKTUR SENYAWA TURUNAN ASAM NAFTIL PROPIONAT SEBAGAI KANDIDAT OBAT ANTIRADANG BUKAN STEROID
| Main Author: | Sary, Indah Purnama |
|---|---|
| Format: | Article |
| Terbitan: |
Lembaga Penelitian Universitas Jember
, 2015
|
| Subjects: | |
| Online Access: |
http://repository.unej.ac.id/handle/123456789/62721 |
| ctrlnum |
123456789-62721 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title>KAJIAN STRUKTUR SENYAWA TURUNAN ASAM NAFTIL PROPIONAT SEBAGAI KANDIDAT OBAT ANTIRADANG BUKAN STEROID</title><creator>Sary, Indah Purnama</creator><subject>naphthyl propionic acid</subject><subject>study on structure</subject><description>Anti-inflammatory activities of naphthyl propionic acid and its derivatives had been studied by molecular mechanics using ChemOffice® 2004 software. Results showed that anti-inflammatory activity of these compounds seem to be determined by a presence of sinister stereochemical configuration of the asymmetric centre of carbon 2 of substituted propionic acid, a presence of an acidic functional group at the carbon 2’ of naphthyl ring, a presence of a heteroatomic substituent having negative inductive effect at the carbon 6’ of naphthyl ring, and interatomic distance between heteroatom-bound H atom and naphthyl ring of 3.128 ± 0.575 Å with the optimum distance of 3.264 Å for naproxen.</description><date>2015-06-24T03:13:06Z</date><date>2015-06-24T03:13:06Z</date><date>2010-01</date><type>Journal:Article</type><identifier>14128136</identifier><identifier>http://repository.unej.ac.id/handle/123456789/62721</identifier><relation>Jurnal Sains dan Teknologi;Vol. 9 No. 1 hal 59-67</relation><publisher>Lembaga Penelitian Universitas Jember</publisher><recordID>123456789-62721</recordID></dc>
|
| format |
Journal:Article Journal |
| author |
Sary, Indah Purnama |
| title |
KAJIAN STRUKTUR SENYAWA TURUNAN ASAM NAFTIL PROPIONAT SEBAGAI KANDIDAT OBAT ANTIRADANG BUKAN STEROID |
| publisher |
Lembaga Penelitian Universitas Jember |
| publishDate |
2015 |
| topic |
naphthyl propionic acid study on structure |
| url |
http://repository.unej.ac.id/handle/123456789/62721 |
| contents |
Anti-inflammatory activities of naphthyl propionic acid and its derivatives had been studied by molecular mechanics using ChemOffice® 2004 software. Results showed that anti-inflammatory activity of these compounds seem to be determined by a presence of sinister stereochemical configuration of the asymmetric centre of carbon 2 of substituted propionic acid, a presence of an acidic functional group at the carbon 2’ of naphthyl ring, a presence of a heteroatomic substituent having negative inductive effect at the carbon 6’ of naphthyl ring, and interatomic distance between heteroatom-bound H atom and naphthyl ring of 3.128 ± 0.575 Å with the optimum distance of 3.264 Å for naproxen. |
| id |
IOS3316.123456789-62721 |
| institution |
Universitas Jember |
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63 |
| institution_type |
library:university library |
| library |
Perpustakaan Universitas Jember |
| library_id |
516 |
| collection |
Tesis S1 Universitas Jember |
| repository_id |
3316 |
| subject_area |
Arsitektur Astronomi Biografi |
| city |
JEMBER |
| province |
JAWA TIMUR |
| repoId |
IOS3316 |
| first_indexed |
2017-01-20T15:14:19Z |
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2017-01-20T15:14:19Z |
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dc |
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1675301670759694336 |
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17.607244 |