KAJIAN STRUKTUR SENYAWA TURUNAN ASAM NAFTIL PROPIONAT SEBAGAI KANDIDAT OBAT ANTIRADANG BUKAN STEROID
| Main Author: | Sary, Indah Purnama |
|---|---|
| Format: | Article |
| Terbitan: |
Lembaga Penelitian Universitas Jember
, 2015
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| Subjects: | |
| Online Access: |
http://repository.unej.ac.id/handle/123456789/62721 |
Daftar Isi:
- Anti-inflammatory activities of naphthyl propionic acid and its derivatives had been studied by molecular mechanics using ChemOffice® 2004 software. Results showed that anti-inflammatory activity of these compounds seem to be determined by a presence of sinister stereochemical configuration of the asymmetric centre of carbon 2 of substituted propionic acid, a presence of an acidic functional group at the carbon 2’ of naphthyl ring, a presence of a heteroatomic substituent having negative inductive effect at the carbon 6’ of naphthyl ring, and interatomic distance between heteroatom-bound H atom and naphthyl ring of 3.128 ± 0.575 Å with the optimum distance of 3.264 Å for naproxen.